DRSC/TRiP Functional Genomics Resources

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Protein Alignment Delta and DLL4

DIOPT Version :10

Sequence 1:NP_477264.1 Gene:Delta / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_061947.1 Gene:DLL4 / 54567 HGNCID:2910 Length:685 Species:Homo sapiens


Alignment Length:648 Identity:255/648 - (39%)
Similarity:345/648 - (53%) Gaps:107/648 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 WIKCLLTAFICFTVIVQVHSSGS--FELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRF 65
            |...||.|      :.|..::||  |:|:|:.|.|:.|....||.|.           ..|:|.|
Human    11 WALLLLVA------LWQQRAAGSGVFQLQLQEFINERGVLASGRPCE-----------PGCRTFF 58

  Fly    66 RVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIV 130
            ||||||:||.: :...||:|.|.||:||.||..:.|.   .:.|..||:|.||:|:||||||||:
Human    59 RVCLKHFQAVV-SPGPCTFGTVSTPVLGTNSFAVRDD---SSGGGRNPLQLPFNFTWPGTFSLII 119

  Fly   131 EAWHDTNNSGNARTNKL----LIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGS 191
            ||||...:  :.|...|    ||.::.:|..|.|...|..::..|..|.|.|.:||.|..||||.
Human   120 EAWHAPGD--DLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGD 182

  Fly   192 GCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKG 254
            .|::.|:.|:|.|||..|...|.:.||.||.|:||..|.|..||  ::|:|.||.:|:|:.||:|
Human   183 NCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQG 247

  Fly   255 ALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKC 319
            .|||||:....|.||||:.||.|.|:||||||:|:|||||||:|.|||||.||.|:|:..|||.|
Human   248 RLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTC 312

  Fly   320 APGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC- 383
            .|||:|.|||.|:..||:  |||:|||:|.|:   :.||.|.|..|:.|..||...|:|:|.|| 
Human   313 RPGYTGVDCELELSECDS--NPCRNGGSCKDQ---EDGYHCLCPPGYYGLHCEHSTLSCADSPCF 372

  Fly   384 HQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSC---QPSGKCICPAGF 445
            :.|.||.     .::|..|.||||..::|.||:.::|.|:.|||.|||.|   .||..|.|..||
Human   373 NGGSCRE-----RNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGF 432

  Fly   446 SGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLN 510
            :||.||.::.||..:                                      |||:||||.:|.
Human   433 TGTYCELHVSDCARN--------------------------------------PCAHGGTCHDLE 459

  Fly   511 NDYQCTCRAGFTGKDCSV--DIDECSSGPCHNGGTCMN--RVNSFECVCANGFRGKQCDEESYDS 571
            |...|||.|||:|:.|.|  .||.|:|.||.|..||..  ..::|.|.|..||.|.:|:      
Human   460 NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE------ 518

  Fly   572 VTFDAHQYGATTQARADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEA 634
              |..            ||..:...:.....|.:.::.|:...|...:::.|.|..:....||
Human   519 --FPV------------GLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSREA 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DeltaNP_477264.1 MNNL 23..182 CDD:462222 64/164 (39%)
DSL 164..226 CDD:128366 26/61 (43%)
EGF_CA 291..329 CDD:238011 25/37 (68%)
EGF_CA 337..372 CDD:238011 14/34 (41%)
EGF_CA 453..488 CDD:238011 2/34 (6%)
EGF_CA 492..526 CDD:238011 16/33 (48%)
EGF_CA 529..564 CDD:238011 15/36 (42%)
DLL4NP_061947.1 MNNL 27..173 CDD:462222 63/162 (39%)
DSL 175..220 CDD:460202 21/44 (48%)
Interaction with Notch1. /evidence=ECO:0000250|UniProtKB:D3ZHH1 185..187 0/1 (0%)
Interaction with Notch1. /evidence=ECO:0000250|UniProtKB:D3ZHH1 191..195 2/3 (67%)
EGF_CA 284..322 CDD:238011 25/37 (68%)
EGF_CA 327..360 CDD:238011 16/37 (43%)
EGF_CA 403..438 CDD:238011 17/34 (50%)
EGF_CA <447..476 CDD:238011 16/66 (24%)

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