Protein Alignment Delta and NOTCH4

DIOPT Version :10

• Sequence 1: NP_477264.1
• Gene: Delta / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: NP_004548.3
• Gene: NOTCH4 / 4855
• HGNCID: 7884
• Length: 2003
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 154/476 - (32%)
• Similarity: 212/476 - (44%)
• Gaps: 81/476 - (17%)

  Fly   180 FRVTCDLNYYGSGC---AKFCRPRDDSFGHSTCSETGEIICL--TGWQGDYCHIPKCAKG----- 234
            |...|...:.|..|   ...|.......|.|.....|...||  :|:.|..|.:|.||..
Human   573 FHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPK 637

  Fly   235 -----------------------------CEHGHCDKPNQCVCQLGWKGALCNE----CVLEPNC 266
                                         |.||||.: :.|||.:||.|..|..    |:..| |
Human   638 QICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQR-SSCVCDVGWTGPECEAELGGCISAP-C 700

  Fly   267 IH-GTC-NKP--WTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDD 327
            .| ||| .:|  :.|.|..|:.|..|::::..| :..||.|||:| |...|.|.|.|.|.::|..
Human   701 AHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTAC-HSGPCLNGGSC-NPSPGGYYCTCPPSHTGPQ 763

  Fly   328 CENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVL-TCSDKPC-HQGICRN 390
            |:.....|.:  .||.|||||::.|.|   :.|.||.|:.|..||.|:. :|:|.|| ::..|::
Human   764 CQTSTDYCVS--APCFNGGTCVNRPGT---FSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQD 823

  Fly   391 VRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSC---QPSGKCICPAGFSGTRCET 452
                   ..||.:|.||.||:|.:|...:|.|:..||.....|   .||..|:|..|::|..|..
Human   824 -------SPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNL 881

  Fly   453 NIDDC----------LGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCL 507
            .:..|          :...|.|||.|:|....|.|.|.|||.|:.|...|:.|..|||.||.||:
Human   882 PLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCM 946

  Fly   508 NLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSV 572
            ...:.|.|.|..|:.|::||.::|.|.|.||||.|||..:...|.|.|..||.|.:|:.:..:.:
Human   947 AQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECL 1011

  Fly   573 TFDAHQYGATTQARADGLTNA 593
            ....|..|.   |....|.||
Human  1012 DQPCHPTGT---AACHSLANA 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Delta	NP_477264.1	MNNL	23..182	CDD:462222	1/1 (100%)
		DSL	164..226	CDD:128366	12/50 (24%)
		EGF_CA	291..329	CDD:238011	14/37 (38%)
		EGF_CA	337..372	CDD:238011	14/34 (41%)
		EGF_CA	453..488	CDD:238011	14/44 (32%)
		EGF_CA	492..526	CDD:238011	14/33 (42%)
		EGF_CA	529..564	CDD:238011	16/34 (47%)
NOTCH4	NP_004548.3	EGF_CA	194..225	CDD:429571
		EGF	280..308	CDD:394967
		EGF_CA	314..353	CDD:238011
		EGF_CA	<364..390	CDD:238011
		EGF_CA	432..473	CDD:238011
		EGF_CA	475..511	CDD:238011
		EGF_CA	515..549	CDD:238011
		EGF_CA	551..587	CDD:238011	3/13 (23%)
		EGF_CA	590..625	CDD:238011	8/34 (24%)
		EGF_CA	<699..726	CDD:238011	11/27 (41%)
		EGF_CA	<736..765	CDD:238011	13/29 (45%)
		EGF_CA	769..803	CDD:238011	15/38 (39%)
		EGF_CA	<813..842	CDD:238011	11/35 (31%)
		EGF_CA	<899..928	CDD:238011	13/28 (46%)
		EGF_CA	931..965	CDD:238011	14/33 (42%)
		EGF_CA	970..1004	CDD:238011	16/33 (48%)
		EGF_CA	1047..1084	CDD:238011
		Notch	1168..1204	CDD:459658
		LNR 1	1170..1213
		Notch	1211..1246	CDD:459658
		LNR 2	1214..1250
		Notch	1249..1285	CDD:459658
		LNR 3	1251..1294
		NOD	1295..1344	CDD:462014
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1347..1371
		NODP	1379..>1420	CDD:462229
		JMTM_Notch4	1431..1515	CDD:411988
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1485..1508
		ANK repeat	1586..1630	CDD:293786
		ANKYR	<1619..1823	CDD:440430
		ANK 1	1633..1665
		ANK repeat	1634..1664	CDD:293786
		ANK repeat	1666..1698	CDD:293786
		ANK 2	1666..1698
		ANK 3	1700..1732
		ANK repeat	1700..1731	CDD:293786
		ANK 4	1733..1765
		ANK repeat	1733..1764	CDD:293786
		ANK 5	1766..1798
		ANK repeat	1766..1797	CDD:293786
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1900..1927
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1968..2003