DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dl and Notch4

DIOPT Version :9

Sequence 1:NP_001247193.1 Gene:Dl / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_001002827.1 Gene:Notch4 / 406162 RGDID:1303282 Length:1961 Species:Rattus norvegicus


Alignment Length:973 Identity:246/973 - (25%)
Similarity:347/973 - (35%) Gaps:309/973 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 CSGE----SDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQ 106
            |.|.    ::|.|             ||:..|.  ..|.||..|     .|||.           
  Rat    25 CGGSPEPCANGGT-------------CLRLSQG--QGTCQCAPG-----FLGET----------- 58

  Fly   107 NKGFTNPIQFPFSFSWPGTFSLIVEAWHDT---NNSGNARTNKLLIQRLLVQQVLEVSSEWKTNK 168
                   .|||            ...| ||   .|.|:.            |.:|..:.     .
  Rat    59 -------CQFP------------DPCW-DTQLCENGGSC------------QALLPTAP-----S 86

  Fly   169 SESQYTSLEYDFRVTCDLNYYGSGC----AKFCRPRDDSF----GHSTCSETG--EIICLTGWQG 223
            |.|..:.|...|..||...:.|..|    .:.|.|   ||    ||.:...:|  :..|..||.|
  Rat    87 SHSPTSPLTPHFSCTCPSGFTGDRCQSPLEELCPP---SFCSNGGHCSVQVSGRPQCSCEPGWTG 148

  Fly   224 ------DYCHIPKCAKGCEHGHC--DKPN-QCVCQLGWKGALC----NECVLEPN---------- 265
                  |:|....||.|   |.|  ..|. ||.|..|::|.:|    |||.|||.          
  Rat   149 EQCQLRDFCSANPCANG---GVCLATYPQIQCRCPTGFEGHICERDVNECFLEPGPCPRGTSCHN 210

  Fly   266 ------------------------CIHGTCNKPWT-------------CICNEGWGGLYCNQDLN 293
                                    |:.|||....|             |:|..|:.||.|..:.:
  Rat   211 TLGSFQCLCPVGQEGPQCKLRKGACLPGTCLNGGTCQLVPEGDTTFHLCLCPPGFTGLNCEMNPD 275

  Fly   294 YCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNP-CQNGGTCIDEPHTKTG 357
            .|..:: |:||.|| ..|.|.|||.|...:.|.||..:|..|:|...| |:|||||   .::..|
  Rat   276 DCVRNQ-CQNGATC-QDGLGTYTCLCPKTWKGWDCSEDIDECEAQGPPRCRNGGTC---QNSAGG 335

  Fly   358 YKCHCANGWSGKMCEEKV-----------LTCSDK--------------------------PCHQ 385
            :.|.|.:||.|:.|:|.:           .||.|:                          |||.
  Rat   336 FHCVCVSGWGGEGCDENLDDCAAATCALGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLRQPCHV 400

  Fly   386 GICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNC-----SPNPCINGGSC---QPSGKCICP 442
            ....:..|..||.    .|.|..|||||.|...||.|     .|:||.:||||   ..|..|:|.
  Rat   401 NAQCSTNPLTGST----LCICQPGYSGPTCHQDLDECQMAQQGPSPCEHGGSCINTPGSFNCLCL 461

  Fly   443 AGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCL 507
            .|::|:|||.:.::||...|..|.||:|::..::|.|.||..|..|..:::.|...||.|...|.
  Rat   462 PGYTGSRCEADHNECLSQPCHPGSTCLDLLATFQCLCPPGLEGRLCEVEINECASNPCLNQAACH 526

  Fly   508 NLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSV 572
            :..|.:.|.|..||||..|..|:|||||.||.|||.|.::..:|.|.|..||.|.:|:.|: |..
  Rat   527 DQLNGFLCLCLPGFTGARCEKDMDECSSAPCANGGHCQDQPGAFHCECLPGFEGPRCETEA-DEC 590

  Fly   573 TFDAHQYGATTQARADGLTNAQVVLIAVFSVAMP-----LVAVIAACVVFCMKRKRKRAQE---- 628
            ..|....||:..    .|..|.:.|      ..|     |..|.....:.|...::.:.||    
  Rat   591 RSDPCPVGASCL----DLPGAFLCL------CRPGFTGQLCEVPLCSPILCQPGQQCQDQEHRAP 645

  Fly   629 -------------KDDAEARKQNEQNAVATMHHNGSG------VGVALAS--------------- 659
                         :||......:.|.::...:...:|      :|..|::               
  Rat   646 CLCPDGSPGCVPAEDDCPCHHGHCQRSLCVCNEGWTGPECETELGGCLSTPCAHGGTCHPQPSGY 710

  Fly   660 --ASLGGKTG---------SNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADECLMY 713
              :.|.|.||         .:||...:||:.:|    ..:..:..|..:........|.|.|.. 
  Rat   711 NCSCLAGYTGLTCSEEITACHSGPCLNGGSCSI----HPEGYSCTCPPSHTGPHCQTAVDHCAS- 770

  Fly   714 GGYVASVADNNNANSD------FCVAPLQRAKSQKQLNTDPTLMHRGSPAGSSA------KGA-- 764
                ||..:.....|.      .|....|....:|:::  |:.  ..:|..:.|      :||  
  Rat   771 ----ASCLNGGTCMSKPGTFFCHCATGFQGLHCEKKIH--PSC--ADNPCRNKATCQDTPRGARC 827

  Fly   765 --SGGGPGAAEGKRISVLG-----EGSYCSQRWPS---LAAAGVAGA-CSSQLMAAASVAGSG 816
              |.|..|::....|.:..     ..:.|.|..||   |...|..|: |...|...|:....|
  Rat   828 LCSPGYTGSSCQTLIDLCARKPCPHTARCLQSGPSFHCLCHQGWTGSLCDLPLSCQAAAMSQG 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DlNP_001247193.1 MNNL 23..96 CDD:284966 14/53 (26%)
DSL 164..226 CDD:279722 20/77 (26%)
EGF_CA 291..329 CDD:238011 14/37 (38%)
EGF_CA 337..372 CDD:238011 14/35 (40%)
EGF_CA 453..488 CDD:238011 12/34 (35%)
EGF_CA 492..526 CDD:238011 12/33 (36%)
EGF_CA 529..564 CDD:238011 18/34 (53%)
Notch4NP_001002827.1 EGF_CA 191..>224 CDD:284955 6/32 (19%)
EGF_CA 311..349 CDD:238011 16/40 (40%)
EGF_CA 352..387 CDD:238011 3/34 (9%)
EGF_CA 429..470 CDD:238011 16/40 (40%)
EGF_CA 472..508 CDD:238011 12/35 (34%)
EGF_CA 511..546 CDD:238011 12/34 (35%)
EGF_CA 548..584 CDD:238011 18/35 (51%)
EGF_CA 588..622 CDD:238011 9/43 (21%)
EGF_CA <696..723 CDD:238011 4/26 (15%)
EGF_CA 765..800 CDD:238011 7/39 (18%)
EGF_CA <810..839 CDD:238011 7/28 (25%)
EGF_CA 892..924 CDD:238011
EGF_CA 927..961 CDD:238011
EGF_CA 966..1000 CDD:238011
EGF_CA 1002..1040 CDD:238011
Notch 1207..1242 CDD:278494
Notch 1245..1281 CDD:278494
NOD 1291..1337 CDD:284282
NODP 1376..>1415 CDD:284987
Ank_2 <1571..1656 CDD:289560
ANK 1625..1732 CDD:238125
ANK repeat 1626..1656 CDD:293786
Ank_2 1630..1723 CDD:289560
ANK repeat 1658..1690 CDD:293786
ANK 1687..1811 CDD:238125
ANK repeat 1692..1723 CDD:293786
Ank_2 1697..1789 CDD:289560
ANK repeat 1725..1756 CDD:293786
ANK repeat 1758..1789 CDD:293786
ANK repeat 1791..1827 CDD:293786
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338540
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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