DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Delta and Notch4

DIOPT Version :10

Sequence 1:NP_477264.1 Gene:Delta / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_001002827.1 Gene:Notch4 / 406162 RGDID:1303282 Length:1961 Species:Rattus norvegicus


Alignment Length:973 Identity:246/973 - (25%)
Similarity:347/973 - (35%) Gaps:309/973 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 CSGE----SDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQ 106
            |.|.    ::|.|             ||:..|.  ..|.||..|     .|||.           
  Rat    25 CGGSPEPCANGGT-------------CLRLSQG--QGTCQCAPG-----FLGET----------- 58

  Fly   107 NKGFTNPIQFPFSFSWPGTFSLIVEAWHDT---NNSGNARTNKLLIQRLLVQQVLEVSSEWKTNK 168
                   .|||            ...| ||   .|.|:.            |.:|..:.     .
  Rat    59 -------CQFP------------DPCW-DTQLCENGGSC------------QALLPTAP-----S 86

  Fly   169 SESQYTSLEYDFRVTCDLNYYGSGC----AKFCRPRDDSF----GHSTCSETG--EIICLTGWQG 223
            |.|..:.|...|..||...:.|..|    .:.|.|   ||    ||.:...:|  :..|..||.|
  Rat    87 SHSPTSPLTPHFSCTCPSGFTGDRCQSPLEELCPP---SFCSNGGHCSVQVSGRPQCSCEPGWTG 148

  Fly   224 ------DYCHIPKCAKGCEHGHC--DKPN-QCVCQLGWKGALC----NECVLEPN---------- 265
                  |:|....||.|   |.|  ..|. ||.|..|::|.:|    |||.|||.          
  Rat   149 EQCQLRDFCSANPCANG---GVCLATYPQIQCRCPTGFEGHICERDVNECFLEPGPCPRGTSCHN 210

  Fly   266 ------------------------CIHGTCNKPWT-------------CICNEGWGGLYCNQDLN 293
                                    |:.|||....|             |:|..|:.||.|..:.:
  Rat   211 TLGSFQCLCPVGQEGPQCKLRKGACLPGTCLNGGTCQLVPEGDTTFHLCLCPPGFTGLNCEMNPD 275

  Fly   294 YCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNP-CQNGGTCIDEPHTKTG 357
            .|..:: |:||.|| ..|.|.|||.|...:.|.||..:|..|:|...| |:|||||   .::..|
  Rat   276 DCVRNQ-CQNGATC-QDGLGTYTCLCPKTWKGWDCSEDIDECEAQGPPRCRNGGTC---QNSAGG 335

  Fly   358 YKCHCANGWSGKMCEEKV-----------LTCSDK--------------------------PCHQ 385
            :.|.|.:||.|:.|:|.:           .||.|:                          |||.
  Rat   336 FHCVCVSGWGGEGCDENLDDCAAATCALGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLRQPCHV 400

  Fly   386 GICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNC-----SPNPCINGGSC---QPSGKCICP 442
            ....:..|..||.    .|.|..|||||.|...||.|     .|:||.:||||   ..|..|:|.
  Rat   401 NAQCSTNPLTGST----LCICQPGYSGPTCHQDLDECQMAQQGPSPCEHGGSCINTPGSFNCLCL 461

  Fly   443 AGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCL 507
            .|::|:|||.:.::||...|..|.||:|::..::|.|.||..|..|..:::.|...||.|...|.
  Rat   462 PGYTGSRCEADHNECLSQPCHPGSTCLDLLATFQCLCPPGLEGRLCEVEINECASNPCLNQAACH 526

  Fly   508 NLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSV 572
            :..|.:.|.|..||||..|..|:|||||.||.|||.|.::..:|.|.|..||.|.:|:.|: |..
  Rat   527 DQLNGFLCLCLPGFTGARCEKDMDECSSAPCANGGHCQDQPGAFHCECLPGFEGPRCETEA-DEC 590

  Fly   573 TFDAHQYGATTQARADGLTNAQVVLIAVFSVAMP-----LVAVIAACVVFCMKRKRKRAQE---- 628
            ..|....||:..    .|..|.:.|      ..|     |..|.....:.|...::.:.||    
  Rat   591 RSDPCPVGASCL----DLPGAFLCL------CRPGFTGQLCEVPLCSPILCQPGQQCQDQEHRAP 645

  Fly   629 -------------KDDAEARKQNEQNAVATMHHNGSG------VGVALAS--------------- 659
                         :||......:.|.::...:...:|      :|..|::               
  Rat   646 CLCPDGSPGCVPAEDDCPCHHGHCQRSLCVCNEGWTGPECETELGGCLSTPCAHGGTCHPQPSGY 710

  Fly   660 --ASLGGKTG---------SNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADECLMY 713
              :.|.|.||         .:||...:||:.:|    ..:..:..|..:........|.|.|.. 
  Rat   711 NCSCLAGYTGLTCSEEITACHSGPCLNGGSCSI----HPEGYSCTCPPSHTGPHCQTAVDHCAS- 770

  Fly   714 GGYVASVADNNNANSD------FCVAPLQRAKSQKQLNTDPTLMHRGSPAGSSA------KGA-- 764
                ||..:.....|.      .|....|....:|:::  |:.  ..:|..:.|      :||  
  Rat   771 ----ASCLNGGTCMSKPGTFFCHCATGFQGLHCEKKIH--PSC--ADNPCRNKATCQDTPRGARC 827

  Fly   765 --SGGGPGAAEGKRISVLG-----EGSYCSQRWPS---LAAAGVAGA-CSSQLMAAASVAGSG 816
              |.|..|::....|.:..     ..:.|.|..||   |...|..|: |...|...|:....|
  Rat   828 LCSPGYTGSSCQTLIDLCARKPCPHTARCLQSGPSFHCLCHQGWTGSLCDLPLSCQAAAMSQG 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DeltaNP_477264.1 MNNL 23..182 CDD:462222 28/142 (20%)
DSL 164..226 CDD:128366 20/77 (26%)
EGF_CA 291..329 CDD:238011 14/37 (38%)
EGF_CA 337..372 CDD:238011 14/35 (40%)
EGF_CA 453..488 CDD:238011 12/34 (35%)
EGF_CA 492..526 CDD:238011 12/33 (36%)
EGF_CA 529..564 CDD:238011 18/34 (53%)
Notch4NP_001002827.1 EGF_CA 191..222 CDD:429571 6/30 (20%)
EGF_CA 311..349 CDD:238011 16/40 (40%)
EGF_CA 352..387 CDD:238011 3/34 (9%)
EGF_CA 429..470 CDD:238011 16/40 (40%)
EGF_CA 472..508 CDD:238011 12/35 (34%)
EGF_CA 511..546 CDD:238011 12/34 (35%)
EGF_CA 548..584 CDD:238011 18/35 (51%)
EGF_CA 588..622 CDD:238011 9/43 (21%)
EGF_CA <696..723 CDD:238011 4/26 (15%)
EGF_CA 765..800 CDD:238011 7/39 (18%)
EGF_CA <810..839 CDD:238011 7/28 (25%)
EGF_CA 892..924 CDD:238011
EGF_CA 927..961 CDD:238011
EGF_CA 966..1000 CDD:238011
EGF_CA 1002..1040 CDD:238011
Notch 1207..1242 CDD:459658
Notch 1245..1281 CDD:459658
NOD 1291..1340 CDD:462014
JMTM_Notch4 1436..1511 CDD:411988
ANKYR <1611..1828 CDD:440430
ANK repeat 1626..1656 CDD:293786
ANK repeat 1658..1690 CDD:293786
ANK repeat 1692..1723 CDD:293786
ANK repeat 1725..1756 CDD:293786
ANK repeat 1758..1789 CDD:293786
ANK repeat 1791..1827 CDD:293786
Blue background indicates that the domain is not in the aligned region.

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