Protein Alignment Dl and JAG2

DIOPT Version :9

• Sequence 1: NP_001247193.1
• Gene: Dl / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: NP_002217.3
• Gene: JAG2 / 3714
• HGNCID: 6189
• Length: 1238
• Species: Homo sapiens
• Alignment Length: 925
• Identity: 287/925 - (31%)
• Similarity: 376/925 - (40%)
• Gaps: 236/925 - (25%)

  Fly    24 GSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLG----SCKTRFRVCLKHYQATIDTTSQCTY 84
            |.|||:|....|.:|....|.||.|  ||.|.:..|    .|.|..|||||.|||.:..|..|:|
Human    28 GYFELQLSALRNVNGELLSGACCDG--DGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSY 90

  Fly    85 GDVITPILGENSVNLTDA--------QRFQNKGFTNP--IQFPFSFSWPGTFSLIVEAWH-DTNN 138
            |...||:||.||..|..|        .|.:..|..:|  :..||.|:||.:|:||||||. |.:.
Human    91 GHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDT 155

  Fly   139 SGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDS 203
            :.|   .:|||:|:....::.....||:.........||...||.||.|||.:.|.||||||:|.
Human   156 TPN---EELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDF 217

  Fly   204 FGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVCQLGWKGALCNECVLEPNC 266
            |||.||.:.|...|:.||.|..|....|.:||.  ||.|..|.:|.|..||:|..|:|||..|.|
Human   218 FGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGC 282

  Fly   267 IHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENE 331
            :||:|.:||.|.|...||||.|::|||||.:|.||.|||||.|.....|.|.|..||||.:||..
Human   283 VHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKA 347

  Fly   332 IYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQ-GICRNVRPGL 395
            .::|.:  |||.|||:|.:.|   :|::|||.:||||..|...:..|:..||.. |.|.:
Human   348 EHACTS--NPCANGGSCHEVP---SGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVD----- 402

  Fly   396 GSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCING------------------------------ 430
              :..|::|.||..:.|..|.|..:.|...||:|.
Human   403 --QVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC 465

  Fly   431 -GSCQPSG---------KCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHG 485
             |.||..|         :|:||.||.|..||...|:|....|.:||.|.|:.:.:.|.|..||.|
Human   466 RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSG 530

  Fly   486 THCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSV---------------------- 528
            ..|...||||...||.||..|.||..||.|.|...|.||:|||
Human   531 PLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGP 595

  Fly   529 ----------------------------------------DIDECSSGPCHNGGTCMNRVNSFEC 553
                                                    :||:|...||.|||||::.|::|.|
Human   596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 660

  Fly   554 VCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTNAQVVLIAVFSVAMPLVAVIAACVVFC 618
            .|.:|:.|:.||....|.:....|..|     |...|.|                ....||
Human   661 FCPSGWEGELCDTNPNDCLPDPCHSRG-----RCYDLVN----------------DFYCAC---- 700

  Fly   619 MKRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVGVALASASLGGKTGSNSGLTFDGGN----- 678
                       ||....|        |.|..         .......|.||.|..:|.|:
Human   701 -----------DDGWKGK--------TCHSR---------EFQCDAYTCSNGGTCYDSGDTFRCA 737

  Fly   679 --PN-------IIKNTWDKSVNNICASAAAAAAAAAAADECLMYGGYVASVADNNN--------A 726
              |.       :.||:  ..:.|.|.:......:.|:. .|:...|:......:|.        .
Human   738 CPPGWKGSTCAVAKNS--SCLPNPCVNGGTCVGSGASF-SCICRDGWEGRTCTHNTNDCNPLPCY 799

  Fly   727 NSDFCV----------APLQRAKSQKQLNTDPTLMHRGSPA--GSSAKGASGG-----GPGAAEG 774
            |...||          || ..|....::|.|..   :.||.  |::......|     .||.|..
Human   800 NGGICVDGVNWFRCECAP-GFAGPDCRINIDEC---QSSPCAYGATCVDEINGYRCSCPPGRAGP 860

  Fly   775 KRISVLGEGSYCSQR 789
            :...|:|.|..|..|
Human   861 RCQEVIGFGRSCWSR 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	33/75 (44%)
		DSL	164..226	CDD:279722	29/61 (48%)
		EGF_CA	291..329	CDD:238011	21/37 (57%)
		EGF_CA	337..372	CDD:238011	16/34 (47%)
		EGF_CA	453..488	CDD:238011	12/34 (35%)
		EGF_CA	492..526	CDD:238011	18/33 (55%)
		EGF_CA	529..564	CDD:238011	16/34 (47%)
JAG2	NP_002217.3	MNNL	28..102	CDD:284966	33/75 (44%)
		DSL	178..240	CDD:279722	29/61 (48%)
		EGF_CA	307..345	CDD:238011	21/37 (57%)
		EGF	351..381	CDD:278437	17/34 (50%)
		EGF_CA	385..421	CDD:238011	10/42 (24%)
		EGF_CA	423..458	CDD:238011	4/34 (12%)
		EGF_CA	461..496	CDD:238011	10/34 (29%)
		EGF_CA	500..534	CDD:238011	12/33 (36%)
		EGF_CA	536..571	CDD:238011	18/34 (53%)
		EGF_CA	636..671	CDD:238011	16/34 (47%)
		EGF_CA	676..709	CDD:238011	11/76 (14%)
		EGF	716..746	CDD:278437	7/29 (24%)
		EGF_CA	757..787	CDD:238011	5/30 (17%)
		EGF_CA	789..824	CDD:238011	7/35 (20%)
		EGF_CA	827..863	CDD:238011	9/38 (24%)
		VWC_out	872..943	CDD:214565	2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1114..1139
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1156..1238

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6068
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920