DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and uif

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_001162899.1	Gene:	uif / 33983	FlyBaseID:	FBgn0031879	Length:	3589	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	176/585 - (30%)
Similarity:	253/585 - (43%)	Gaps:	105/585 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YFSNDHGRDNEG---RCCSG-----ESDGATGKCLGSC------KTRFRVCLKHYQATIDTTSQC 82
            |:.|   ||.:|   ||.:|     |...:...|:..|      .|....||           :|
  Fly  1879 YYQN---RDRQGTCLRCPAGTYTKEEGTKSQADCIPVCGYGTYSPTGLVPCL-----------EC 1929

  Fly    83 TYGDVIT--PILGENSVNLTDAQRF------QNKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNS 139
            .......  |..|........||.|      .||........|.::|..|.........|....:
  Fly  1930 PRNSFTAEPPTGGFKDCQACPAQSFTYQPAASNKDLCRAKCAPGTYSATGLAPCSPCPLHHYQGA 1994

  Fly   140 GNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAK---FCRPRD 201
            ..|            |...|..|..:|:...|:       .|..|.....|.|..:   .|.|
  Fly  1995 AGA------------QSCNECPSNMRTDSPASK-------GREQCKPVVCGEGACQHGGLCVP-- 2038

  Fly   202 DSFGHSTCSETGEIICLTGWQGDYCH--IPKCA-KGCEH-GHC-DKPN--QCVCQLGWKGALCNE 259
              .||..     :..|..|:.|..|.  |.:|| :.|.: |.| |.|.  :|.|..|:.|..|.|
  Fly  2039 --MGHDI-----QCFCPAGFSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCECPAGYSGINCQE 2096

  Fly   260 CVLEPNCIHGTC-------NKPW----TCICNEGWGGLYCNQDLNYCT-NHRPCKNGGTCFNTGE 312
              ...:|.:.||       |:|.    ||:|..|:.|..|:..::.|| |..||.||.:|....:
  Fly  2097 --EASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQ 2159

  Fly   313 GLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLT 377
            |.|.|:|.||:.|..||..|..|..  |||..|..|.|   ....::|.|..|::||.||:|:..
  Fly  2160 GRYKCECVPGWEGIHCEQNINDCSE--NPCLLGANCTD---LVNDFQCACPPGFTGKRCEQKIDL 2219

  Fly   378 CSDKPCHQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSC---QPSGKC 439
            |..:||..|.|.:       :...::|.|..|::|..||:.:|:|...||.|.|:|   .....|
  Fly  2220 CLSEPCKHGTCVD-------RLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSC 2277

  Fly   440 ICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGG 504
            .|..|::|..|:..||||..:.|::|.||:|.::.:.|:|.||:.|..|.:::|.||..||...|
  Fly  2278 NCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVG 2342

  Fly   505 T--CLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEE 567
            |  ||:|:|.::|.||.||.|..|:.|||:|.:.||.|.|.|.:||..|||.|..|:.|.:|:::
  Fly  2343 TERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQ 2407

Fly 568 567
Fly 2408 2407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	17/79 (22%)
		DSL	164..226	CDD:279722	13/64 (20%)
		EGF_CA	291..329	CDD:238011	15/38 (39%)
		EGF_CA	337..372	CDD:238011	11/34 (32%)
		EGF_CA	453..488	CDD:238011	14/34 (41%)
		EGF_CA	492..526	CDD:238011	17/35 (49%)
		EGF_CA	529..564	CDD:238011	17/34 (50%)
uif	NP_001162899.1	CLECT	36..167	CDD:214480
		LDLa	172..206	CDD:238060
		CUB	220..319	CDD:238001
		CUB	326..435	CDD:238001
		CUB	439..550	CDD:238001
		PHA02927	<568..733	CDD:222943
		CCP	675..731	CDD:153056
		CCP	736..791	CDD:153056
		EGF_CA	792..829	CDD:214542
		FA58C	828..977	CDD:214572
		FA58C	833..976	CDD:238014
		FXa_inhibition	988..>1016	CDD:291342
		CCP	1051..1106	CDD:153056
		FA58C	1297..1444	CDD:214572
		FA58C	1303..1443	CDD:238014
		DUF5011	1463..1547	CDD:295940
		DUF5011	1548..1631	CDD:295940
		GCC2_GCC3	1862..1909	CDD:285001	9/32 (28%)
		GCC2_GCC3	1916..1966	CDD:285001	11/60 (18%)
		GCC2_GCC3	1973..2020	CDD:285001	10/65 (15%)
		EGF	2025..2055	CDD:278437	9/38 (24%)
		EGF_CA	2059..2095	CDD:238011	12/35 (34%)
		EGF_CA	2138..2176	CDD:238011	15/37 (41%)
		EGF_CA	2178..2214	CDD:238011	13/40 (33%)
		EGF_CA	2253..2289	CDD:238011	11/35 (31%)
		EGF_CA	2292..2327	CDD:238011	14/34 (41%)
		EGF_CA	2330..2366	CDD:238011	17/35 (49%)
		EGF_CA	2369..2405	CDD:238011	17/35 (49%)
		EGF_CA	2411..2444	CDD:238011
		EGF_CA	2486..2520	CDD:238011
		EGF_CA	2522..2557	CDD:238011
		LamG	2590..2735	CDD:304605
		DUF5011	2799..2877	CDD:295940
		GCC2_GCC3	3149..3200	CDD:285001
		GCC2_GCC3	3207..3254	CDD:285001
		GCC2_GCC3	3268..3307	CDD:285001
		GCC2_GCC3	3315..3362	CDD:285001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910