DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dl and wry

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	146/501 - (29%)
Similarity:	217/501 - (43%)	Gaps:	115/501 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 WQGDYCH---IPKCAKGCEHGHCDKPNQCVCQ-LGWKGAL-----------CNECVL----EPN- 265
            |:|:..|   :|....    .||.....||.. |.|:|..           .|:.:|    |||
  Fly   561 WRGNETHELLLPIVTT----EHCKPDEHCVPNVLTWRGEAEIQSGDILIVEINDAMLNPSHEPNN 621

  Fly   266 ---CIHGT------------C------------------------NKPWT------CICNEGWGG 285
               .:|.|            |                        :|..|      .:.:|.||.
  Fly   622 TSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDGRKLVTLYDKDLTEGVNLLIVVSELWGA 686

  Fly   286 ----LYCNQDLNYCTNHRPCKNGGTCF-NTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQNG 345
                |......:.|..:..|...|.|: |:|...|.|:|..|::|..|| ||.:|:.  :||.|.
  Fly   687 QCVRLKVTTKTDNCGENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCE-EIDACNP--SPCTNN 748

  Fly   346 GTCID--EPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQGICRNVRPGLGSKGQGYQCECPI 408
            |.|:|  :.|....|:|.|..|::||.|:.:    || ||:...|.|....:|:... ::|:|..
  Fly   749 GICVDLSQGHEGNSYQCLCPYGYAGKNCQYE----SD-PCNPAECMNGGSCVGNSTH-FRCDCAP 807

  Fly   409 GYSGPNCDLQLDNCSPNPCINGGSC--QPSG-KCICPAGFSGTRCETNIDDCLGHQCENGGTCID 470
            |::||.|...|:.|..:||:: |.|  |..| :|.|..||:|..|....::|..:.|:|||.|||
  Fly   808 GFTGPLCQHSLNECESSPCVH-GICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECID 871

  Fly   471 MVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCS----VDID 531
            .:..|.|:|..||.|..|..|||.|..:||..|..|::..||:.|.|..|..|.||:    ....
  Fly   872 HIGSYECRCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQ 936

  Fly   532 ECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEE--------SYDSVTFDAH-------QYGA 581
            :|:..||.:||||.:..:||.|.|..|:.|..|::|        |.:.:..||:       .:|:
  Fly   937 QCNVNPCTHGGTCWSSGDSFYCACRPGYTGTMCEDEFVVETVVSSSEFIVDDANARNFNDKTFGS 1001

  Fly   582 TTQARAD-GLTNAQ----VVLIAVFSVAMPLVAVIAACVVFCMKRK 622
            :...::. .|.||.    |:..|:|.||  :|..|..|.|....||
  Fly  1002 SVVLKSPIELHNAYFAAGVLAAAIFIVA--VVVTICHCKVNQTYRK 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966
		DSL	164..226	CDD:279722	2/4 (50%)
		EGF_CA	291..329	CDD:238011	11/38 (29%)
		EGF_CA	337..372	CDD:238011	13/36 (36%)
		EGF_CA	453..488	CDD:238011	14/34 (41%)
		EGF_CA	492..526	CDD:238011	13/33 (39%)
		EGF_CA	529..564	CDD:238011	13/34 (38%)
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	15/41 (37%)
		EGF	783..812	CDD:278437	7/29 (24%)
		EGF_CA	819..851	CDD:238011	12/32 (38%)
		EGF_CA	856..890	CDD:238011	14/33 (42%)
		EGF_CA	893..927	CDD:238011	13/33 (39%)
		EGF_CA	<941..970	CDD:238011	12/28 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010