DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dl and Sned1

DIOPT Version :9

Sequence 1:NP_001247193.1 Gene:Dl / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:XP_038939693.1 Gene:Sned1 / 316638 RGDID:1566079 Length:1504 Species:Rattus norvegicus


Alignment Length:666 Identity:170/666 - (25%)
Similarity:245/666 - (36%) Gaps:214/666 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 RFRVCLKHYQATIDTT-SQCTYG---DVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPG 124
            ||...:.:|::.:.|| :..:.|   |.:..|..:...|..|..|:              |:.||
  Rat   180 RFSFTIFNYESILWTTGTHASSGGDADGLGGIAAQAGFNAGDGHRY--------------FNIPG 230

  Fly   125 TFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQY--------TSLEYDFR 181
            :.:..:.....|.|.|                   |...|.....::|.        ||:....|
  Rat   231 SRTADMAEVETTTNVG-------------------VPGRWAFRIDDAQVRVGGCGHTTSVCLVLR 276

  Fly   182 VTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCH--IPKCAK-GCEHG----H 239
             .| ||  |..|...|...:.|:   |||      ||.|:.|..||  :.:||. .|::|    |
  Rat   277 -PC-LN--GGKCIDDCVTGNPSY---TCS------CLAGFTGRRCHLDVNECASHPCQNGGTCTH 328

  Fly   240 CDKPNQCVCQLGWKGALCNECVLEPNCIHGTC---------NKPWTCICNEGWGGLYCNQDLNYC 295
            ......|.|..|::|..| |....| |.:..|         :....|:|..|:.|..|..|::.|
  Rat   329 GVNSFSCQCPAGFQGPTC-ESAQSP-CDNKVCQNGGQCQAESSSAVCVCQAGYTGATCETDVDEC 391

  Fly   296 TNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADV--NPCQNGGTCIDEPHTKTGY 358
            ::. ||.|||:|.:. .|.|:|.|...:.|..||...|...:..  |||.|||||:|   ...||
  Rat   392 SSD-PCLNGGSCVDL-VGNYSCICVEPFEGPQCETGSYVVPSPCLSNPCLNGGTCVD---ADQGY 451

  Fly   359 KCHCANGWSGKMCEEKVLTCSD--------------------------------KPCHQ------ 385
            .|.|..|:.|..|.|::|...|                                .||:.      
  Rat   452 VCECPEGFMGLDCRERILNDCDCRNGGRCLGANTTICQCPPGFFGLLCEFEVTATPCNMNTQCPD 516

  Fly   386 -GIC--------------RNVRPGLGS---------------KGQGYQCECPIGYSGPNCDLQLD 420
             |.|              .|:...|.|               ....|.||||.|:.|.:|:....
  Rat   517 GGYCMEYGGSYLCVCHTDHNISHSLPSPCDSDPCFNGGSCDAHEDSYTCECPRGFHGRHCEKARP 581

  Fly   421 N-CSPNPCINGGSCQPSG---KCICPAGFSGTRCET-NIDDCLGHQCENGGTCIDMVNQYRCQCV 480
            : ||..||.|||:|:.:|   :|.||..|:|..||. ..|.|....|.|||||...:.:|:|.|.
  Rat   582 HLCSSGPCRNGGTCKETGDEYRCTCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCP 646

  Fly   481 PGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCS------------------ 527
            |||.|.||......|...||.|||.|.:|..|:.|.|:.|:||..|.                  
  Rat   647 PGFSGRHCEIAPSPCFRSPCMNGGICEDLGTDFSCHCQPGYTGHRCQAEVDCGQPEEVKHATMRL 711

  Fly   528 ----------------------------------------VDIDECSSGPCHNGGTCMNRVNSFE 552
                                                    :::|||.|.||.:.|:|.:.:..::
  Rat   712 NGTRMGSVALYTCDPGFSLSVLSHMRVCQPQGVWSQPPQCIEVDECQSQPCLHKGSCQDLIAGYQ 776

  Fly   553 CVCANGFRGKQCDEES 568
            |:|:.|:.|..|:.|:
  Rat   777 CLCSPGYEGVHCELET 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DlNP_001247193.1 MNNL 23..96 CDD:284966 8/35 (23%)
DSL 164..226 CDD:279722 19/69 (28%)
EGF_CA 291..329 CDD:238011 13/37 (35%)
EGF_CA 337..372 CDD:238011 15/36 (42%)
EGF_CA 453..488 CDD:238011 15/34 (44%)
EGF_CA 492..526 CDD:238011 14/33 (42%)
EGF_CA 529..564 CDD:238011 12/34 (35%)
Sned1XP_038939693.1 NIDO 104..260 CDD:214712 19/112 (17%)
EGF_CA 272..308 CDD:238011 15/48 (31%)
EGF_CA 311..347 CDD:238011 10/36 (28%)
EGF_CA 387..423 CDD:238011 13/37 (35%)
EGF_CA 433..464 CDD:238011 15/33 (45%)
EGF_CA 545..577 CDD:238011 7/31 (23%)
EGF_CA 585..616 CDD:238011 13/30 (43%)
EGF_CA 621..655 CDD:238011 16/33 (48%)
EGF_CA <664..693 CDD:238011 13/28 (46%)
CCP 698..752 CDD:153056 0/53 (0%)
EGF_CA 754..789 CDD:238011 12/34 (35%)
EGF_CA 793..827 CDD:238011 170/666 (26%)
EGF_CA 931..966 CDD:238011
fn3 1009..1089 CDD:394996
fn3 1108..1189 CDD:394996
FN3 1205..1297 CDD:238020
EGF_CA 1412..1443 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D197806at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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