DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and N

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_001245510.1	Gene:	N / 31293	FlyBaseID:	FBgn0004647	Length:	2703	Species:	Drosophila melanogaster

Alignment Length:	733	Identity:	204/733 - (27%)
Similarity:	289/733 - (39%)	Gaps:	247/733 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NEGRC---------CSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENS 96
            |.|.|         |:. ::|.||:   .|:|: .:|         .:|.|..|...|.:.|.:|
  Fly   150 NGGTCQLKTLEEYTCAC-ANGYTGE---RCETK-NLC---------ASSPCRNGATCTALAGSSS 200

  Fly    97 VNLT------------DAQRFQNKGFTNPIQFPFS-FSWPGTFSLIVEAWH-----DT------- 136
            ...:            |.:..|    :||.::..: .:..|::..:....:     ||
  Fly   201 FTCSCPPGFTGDTCSYDIEECQ----SNPCKYGGTCVNTHGSYQCMCPTGYTGKDCDTKYKPCSP 261

  Fly   137 ---NNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKS------ESQY------------TSLE--Y 178
               .|.|..|:|.|             |.|.|..|.      |..|            |.::  .
  Fly   262 SPCQNGGICRSNGL-------------SYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGIS 313

  Fly   179 DFRVTCDLNYYGSGC---AKFCRPRDDSF--GHSTCSETG---EIICLTGWQG-------DYCHI 228
            |:...|..|:.|..|   ...|..||...  ..:||:.|.   ..||:.||.|       |.|..
  Fly   314 DYTCRCPPNFTGRFCQDDVDECAQRDHPVCQNGATCTNTHGSYSCICVNGWAGLDCSNNTDDCKQ 378

  Fly   229 PKCAKG--CEHG----HCDKPNQCVCQLGWKGALC--------NECVLEPNCIHGTCNKPWTCIC 279
            ..|..|  |..|    :|.      |..|..|.||        |.|..:..|.....|..:.|.|
  Fly   379 AACFYGATCIDGVGSFYCQ------CTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYACSC 437

  Fly   280 NEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQN 344
            ..|:.|:.|::|::.|....||::.|.|.|| .|.|.|.|:.|::|..||..|..|::  :||||
  Fly   438 ATGYKGVDCSEDIDECDQGSPCEHNGICVNT-PGSYRCNCSQGFTGPRCETNINECES--HPCQN 499

  Fly   345 GGTCIDEP----------------------------------HTK-TGYKCHCANGWSGKMCEEK 374
            .|:|:|:|                                  |.| .|:||.||.|::|..|:..
  Fly   500 EGSCLDDPGTFRCVCMPGFTGTQCEIDIDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQIN 564

  Fly   375 VLTCSDKPC-HQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCING-------- 430
            :..|..:|| ::|||.:       ...||.||||.||:|.:|::.:::|..|||..|
  Fly   565 IDDCQSQPCRNRGICHD-------SIAGYSCECPPGYTGTSCEININDCDSNPCHRGKCIDDVNS 622

  Fly   431 -----------------------------GSCQP---SGKCICPAGFSGTRCETNIDDCLGHQCE 463
                                         |.||.   |..|.|.||.||..||.|:::|..:.|.
  Fly   623 FKCLCDPGYTGYICQKQINECESNPCQFDGHCQDRVGSYYCQCQAGTSGKNCEVNVNECHSNPCN 687

  Fly   464 NGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGF------- 521
            ||.||||.:|.|:|||||||.|.||...||.|:..||||.|.|::..|.|:|.|..||
  Fly   688 NGATCIDGINSYKCQCVPGFTGQHCEKNVDECISSPCANNGVCIDQVNGYKCECPRGFYDAHCLS 752

  Fly   522 -------------------------------TGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVC 555
                                           |||.|.:|||||||.||.:||||.:::|:|.|.|
  Fly   753 DVDECASNPCVNEGRCEDGINEFICHCPPGYTGKRCELDIDECSSNPCQHGGTCYDKLNAFSCQC 817

  Fly   556 ANGFRGKQCDEESYDSVT 573
            ..|:.|::|:....|.||
  Fly   818 MPGYTGQKCETNIDDCVT 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	15/63 (24%)
		DSL	164..226	CDD:279722	22/96 (23%)
		EGF_CA	291..329	CDD:238011	14/37 (38%)
		EGF_CA	337..372	CDD:238011	17/69 (25%)
		EGF_CA	453..488	CDD:238011	19/34 (56%)
		EGF_CA	492..526	CDD:238011	18/71 (25%)
		EGF_CA	529..564	CDD:238011	19/34 (56%)
N	NP_001245510.1	EGF_CA	179..214	CDD:238011	7/43 (16%)
		EGF_CA	217..252	CDD:238011	5/38 (13%)
		EGF_CA	260..291	CDD:238011	9/43 (21%)
		EGF_CA	295..329	CDD:238011	5/33 (15%)
		EGF_CA	331..369	CDD:238011	11/37 (30%)
		EGF_CA	449..486	CDD:238011	14/37 (38%)
		EGF_CA	488..524	CDD:238011	10/37 (27%)
		EGF_CA	526..562	CDD:238011	9/35 (26%)
		EGF_CA	564..600	CDD:238011	15/42 (36%)
		EGF_CA	602..637	CDD:238011	5/34 (15%)
		EGF_CA	640..675	CDD:238011	10/34 (29%)
		EGF_CA	677..713	CDD:238011	20/35 (57%)
		EGF_CA	715..750	CDD:238011	15/34 (44%)
		EGF_CA	753..789	CDD:238011	3/35 (9%)
		EGF_CA	791..827	CDD:238011	19/35 (54%)
		EGF_CA	829..865	CDD:238011	3/7 (43%)
		EGF_CA	907..943	CDD:238011
		EGF_CA	946..982	CDD:238011
		EGF_CA	984..1020	CDD:238011
		EGF_CA	1027..1058	CDD:238011
		EGF_CA	1062..1095	CDD:238011
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	1221..1257	CDD:238011
		EGF_CA	1259..1295	CDD:238011
		EGF_CA	1297..1335	CDD:238011
		EGF_CA	1417..1450	CDD:238011
		NL	1476..1512	CDD:197463
		Notch	1519..1553	CDD:278494
		Notch	1565..1593	CDD:278494
		NOD	1599..1648	CDD:284282
		NODP	1680..1731	CDD:284987
		ANK	1896..2038	CDD:238125
		ANK repeat	1902..1948	CDD:293786
		ANK repeat	1951..1981	CDD:293786
		Ank_5	1970..2025	CDD:290568
		ANK	1978..2104	CDD:238125
		ANK repeat	1984..2015	CDD:293786
		ANK repeat	2017..2048	CDD:293786
		Ank_2	2022..2114	CDD:289560
		ANK repeat	2050..2081	CDD:293786
		ANK repeat	2083..2114	CDD:293786
		DUF3454	2627..2682	CDD:288764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910