DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Delta and Dll4

DIOPT Version :10

Sequence 1:NP_477264.1 Gene:Delta / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_001418638.1 Gene:Dll4 / 311332 RGDID:1309740 Length:686 Species:Rattus norvegicus


Alignment Length:622 Identity:254/622 - (40%)
Similarity:339/622 - (54%) Gaps:91/622 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 SGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDV 87
            ||.|:|||:.|:|:.|....||.|.           ..|:|.||:||||||||. :...||:|:|
  Rat    28 SGIFQLRLQEFANERGMLANGRPCE-----------PGCRTFFRICLKHYQATF-SEGPCTFGNV 80

  Fly    88 ITPILGENSVNLTDAQRFQNKGF-TNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTN--KLLI 149
            .||:||.||..:.|    :|.|. .||:|.||:|:|||||||.::|||...:.....|:  ..||
  Rat    81 STPVLGTNSFVIRD----KNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLI 141

  Fly   150 QRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGE 214
            .::::|..|.|...||:::..:..|.|.|.:||.|..||||..|::.|:.|||.|||..|...|.
  Rat   142 SQIIIQGSLAVGKNWKSDEQNNTLTRLRYSYRVVCSDNYYGDSCSRLCKKRDDHFGHYECQPDGS 206

  Fly   215 IICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNECVLEPNCIHGTCNKPWTC 277
            :.||.||.|.||..|.|..||  ::|:|.||::|.|:.||:|.|||||:....|.||||..||.|
  Rat   207 LSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECNCRPGWQGPLCNECIPHNGCRHGTCTIPWQC 271

  Fly   278 ICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPC 342
            .|:||||||:|:|||||||:|.|||||.||.|:|...|||.|.|||:|:.||.|:..|.:  |||
  Rat   272 ACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGYTCTCLPGYTGEHCELELSKCAS--NPC 334

  Fly   343 QNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNVRPGLGSKGQGYQCEC 406
            :|||:|.|.   :..|.|.|..|:.|:.||...|||:|.|| :.|.||.     .::|..|.|||
  Rat   335 RNGGSCKDH---ENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRE-----RNQGASYACEC 391

  Fly   407 PIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGTRCETNIDDCLGHQCENGGTCIDM 471
            |..::|.||:.::|.|:.|||.|||                             ||.|.|.    
  Rat   392 PPNFTGSNCEKKVDRCTSNPCANGG-----------------------------QCLNRGP---- 423

  Fly   472 VNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDI--DECS 534
              ...|:|.|||.||||...:..|...|||:||||.:|.|...|||.|||:|:.|.|.|  |.|:
  Rat   424 --SRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITNDACA 486

  Fly   535 SGPCHNGGTCMNRV--NSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTNAQVVL 597
            ||||.||.||...:  |:|.|.|..||.|.:|:        |..            ||..:...:
  Rat   487 SGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCE--------FPV------------GLPPSFPWV 531

  Fly   598 IAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEA 634
            .....|.:.::.|:...|...:::.|.|..:.|..||
  Rat   532 AVSLGVGLVVLLVLLVMVAVAVRQLRLRRPDDDSREA 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DeltaNP_477264.1 MNNL 23..182 CDD:462222 64/161 (40%)
DSL 164..226 CDD:128366 27/61 (44%)
EGF_CA 291..329 CDD:238011 24/37 (65%)
EGF_CA 337..372 CDD:238011 13/34 (38%)
EGF_CA 453..488 CDD:238011 11/34 (32%)
EGF_CA 492..526 CDD:238011 17/33 (52%)
EGF_CA 529..564 CDD:238011 18/38 (47%)
Dll4NP_001418638.1 MNNL 28..174 CDD:462222 64/161 (40%)
DSL 156..218 CDD:128366 27/61 (44%)
Interaction with Notch1. /evidence=ECO:0000269|PubMed:25700513 186..188 0/1 (0%)
Interaction with Notch1. /evidence=ECO:0000269|PubMed:25700513 192..196 3/3 (100%)
EGF_CA 285..323 CDD:238011 24/37 (65%)
EGF_CA 329..361 CDD:238011 14/36 (39%)
EGF_CA <370..401 CDD:238011 13/35 (37%)
EGF_CA 404..439 CDD:238011 20/69 (29%)
EGF_CA 442..477 CDD:238011 17/34 (50%)

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