Protein Alignment Delta and notch1a

DIOPT Version :10

• Sequence 1: NP_477264.1
• Gene: Delta / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: NP_571516.1
• Gene: notch1a / 30718
• ZFINID: ZDB-GENE-990415-173
• Length: 2437
• Species: Danio rerio
• Alignment Length: 657
• Identity: 198/657 - (30%)
• Similarity: 282/657 - (42%)
• Gaps: 174/657 - (26%)

  Fly    43 GRCCSGESD----GAT-----GKCLGS-----CKTRFRVCLKHYQATIDTTSQCTYGDVITPILG 93
            |..|:.:.|    ||.     |:||.:     ||     ||:.|:.     .:|
Zfish   405 GSACNQDIDECSLGANPCEHGGRCLNTKGSFQCK-----CLQGYEG-----PRC----------- 448

  Fly    94 ENSVNLTDAQRFQNK--------GFTNPIQFPFSFSWPGTFSLIVE-----------AWHDTNNS 139
            |..||...:...||.        || :.|..|   .:.|.|..|..           ...|..||
Zfish   449 EMDVNECKSNPCQNDATCLDQIGGF-HCICMP---GYEGVFCQINSDDCASQPCLNGKCIDKINS 509

  Fly   140 GNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVT-------CDLN---------Y 188
            .:....|.....|....|.|.:|....|.::......:|....|       |:|:         :
Zfish   510 FHCECPKGFSGSLCQVDVDECASTPCKNGAKCTDGPNKYTCECTPGFSGIHCELDINECASSPCH 574

  Fly   189 YG---SGCAKF---CRPRDDSFGHS--------------------TCSETGE---IICLTGWQGD 224
            ||   .|.|.|   |||     |::                    ||.:...   ..|..|..|.
Zfish   575 YGVCRDGVASFTCDCRP-----GYTGRLCETNINECLSQPCRNGGTCQDRENAYICTCPKGTTGV 634

  Fly   225 YC--HIPKC-AKGCEHGHC-DKPN--QCVCQLGWKGALCN----ECVLEP--------------- 264
            .|  :|..| .|.|::|.| ||.|  :|||:.|:.|::||    :|.|.|
Zfish   635 NCEINIDDCKRKPCDYGKCIDKINGYECVCEPGYSGSMCNINIDDCALNPCHNGGTCIDGVNSFT 699

  Fly   265 ----------------------NCIHGTC---NKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNG 304
                                  .||||:|   ...:.|:|..||.|..|:.::|.|.:: ||.||
Zfish   700 CLCPDGFRDATCLSQHNECSSNPCIHGSCLDQINSYRCVCEAGWMGRNCDININECLSN-PCVNG 763

  Fly   305 GTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGK 369
            |||.:...| |.|.|..|:||.:|:..|..|.:  |||.|.|:|||:   ..|:||:|...::|:
Zfish   764 GTCKDMTSG-YLCTCRAGFSGPNCQMNINECAS--NPCLNQGSCIDD---VAGFKCNCMLPYTGE 822

  Fly   370 MCEEKVLTCSDKPC-HQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSC 433
            :||..:..||.:|| :.|:||.     ....|.:.|.||.|:.|..|::.::.|..|||.|||.|
Zfish   823 VCENVLAPCSPRPCKNGGVCRE-----SEDFQSFSCNCPAGWQGQTCEVDINECVRNPCTNGGVC 882

  Fly   434 Q---PSGKCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLC 495
            :   ...:|.|..||:|..||.:||||..:.|.|||.|.|.||.:.|.|:.||.|..|:..:|.|
Zfish   883 ENLRGGFQCRCNPGFTGALCENDIDDCEPNPCSNGGVCQDRVNGFVCVCLAGFRGERCAEDIDEC 947

  Fly   496 LIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFR 560
            :..||.|||.|.:..|.|.|:|.|||:|.:|.::..:|:...|.|||||::.::||.|||..||.
Zfish   948 VSAPCRNGGNCTDCVNSYTCSCPAGFSGINCEINTPDCTESSCFNGGTCVDGISSFSCVCLPGFT 1012

  Fly   561 GKQCDEE 567
            |..|..:
Zfish  1013 GNYCQHD 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Delta	NP_477264.1	MNNL	23..182	CDD:462222	36/171 (21%)
		DSL	164..226	CDD:128366	19/106 (18%)
		EGF_CA	291..329	CDD:238011	16/37 (43%)
		EGF_CA	337..372	CDD:238011	13/34 (38%)
		EGF_CA	453..488	CDD:238011	17/34 (50%)
		EGF_CA	492..526	CDD:238011	16/33 (48%)
		EGF_CA	529..564	CDD:238011	15/34 (44%)
notch1a	NP_571516.1	EGF_CA	141..174	CDD:238011
		EGF_CA	177..215	CDD:238011
		EGF_CA	294..331	CDD:238011
		EGF_CA	334..369	CDD:238011
		EGF_CA	411..449	CDD:238011	12/58 (21%)
		EGF_CA	451..487	CDD:238011	10/39 (26%)
		EGF_CA	491..524	CDD:238011	5/32 (16%)
		EGF_CA	526..562	CDD:238011	6/35 (17%)
		EGF_CA	564..599	CDD:238011	9/39 (23%)
		EGF_CA	601..637	CDD:238011	5/35 (14%)
		EGF_CA	676..711	CDD:238011	3/34 (9%)
		EGF_CA	716..748	CDD:238011	10/31 (32%)
		EGF_CA	751..787	CDD:238011	16/37 (43%)
		EGF_CA	789..825	CDD:238011	15/40 (38%)
		EGF_CA	867..903	CDD:238011	13/35 (37%)
		EGF_CA	905..940	CDD:238011	17/34 (50%)
		EGF_CA	943..979	CDD:238011	16/35 (46%)
		EGF_CA	986..1017	CDD:238011	14/30 (47%)
		EGF_CA	1019..1055	CDD:238011	0/1 (0%)
		EGF_CA	1144..1178	CDD:238011
		EGF_CA	1182..1217	CDD:238011
		EGF_CA	1219..1263	CDD:238011
		EGF_CA	1265..1303	CDD:238011
		EGF_CA	<1313..1344	CDD:238011
		NL	1440..1477	CDD:197463
		LNR 1	1447..1487
		Notch	1485..1520	CDD:459658
		LNR 2	1488..1525
		Notch	1523..1559	CDD:459658
		LNR 3	1526..1566
		NOD	1564..1619	CDD:462014
		NODP	1663..1720	CDD:462229
		JMTM_Notch1	1712..1789	CDD:411985
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1770..1790
		ANKYR	<1860..2082	CDD:440430
		ANK repeat	1867..1913	CDD:293786
		ANK 1	1867..1910
		ANK repeat	1915..1946	CDD:293786
		ANK 2	1915..1944
		ANK repeat	1948..1979	CDD:293786
		ANK 3	1948..1978
		ANK 4	1982..2011
		ANK repeat	2015..2079	CDD:293786
		ANK 5	2015..2044
		ANK 6	2048..2077
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2127..2174
		Atrophin-1	<2185..>2401	CDD:460830
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2356..2437