DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and dla

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_571029.2	Gene:	dla / 30131	ZFINID:	ZDB-GENE-980526-29	Length:	772	Species:	Danio rerio

Alignment Length:	831	Identity:	307/831 - (36%)
Similarity:	415/831 - (49%)	Gaps:	124/831 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKH 71
            ||...|.:.::.|..|||.|||:|:.|.|..|......||.|....:..:|  .|||.||:||||
Zfish     7 LLLFSILYMLLCQASSSGVFELKLQEFLNKKGVQGNKNCCKGGLTTSYQQC--ECKTFFRICLKH 69

  Fly    72 YQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWH-D 135
            ||........||||..:||:||.||..:.|.  ..:..|||||:..|.|:||||||||:||.| |
Zfish    70 YQPNASPEPPCTYGGTVTPVLGSNSFQVPDT--LPDGSFTNPIRMNFGFTWPGTFSLIIEALHAD 132

  Fly   136 TNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPR 200
            :.........:.:|..:..|:.|.|..:|..:......|.|:|.:|..||.:|||.||:.|||||
Zfish   133 SKEDLTTENPERIISTMTTQRHLTVGEDWSQDLHSVGRTELKYSYRFVCDEHYYGEGCSVFCRPR 197

  Fly   201 DDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNECVLE 263
            ||:|||.||.|.|||||..||:|.||..|.|..||  |||.|:||.:|.|::|:||..|:||:..
Zfish   198 DDAFGHFTCGERGEIICDAGWKGQYCTEPICLPGCDEEHGFCEKPGECKCRVGFKGRYCDECIRY 262

  Fly   264 PNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDC 328
            |.|:||||.:||.|.|.||||||:|||||||||:|:||.||.||.|||:|.|||.|.||:||..|
Zfish   263 PGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCLNGATCSNTGQGSYTCSCRPGFSGASC 327

  Fly   329 ENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNVR 392
            |.|:..|..  |||:|||:|.|..:|   |.|.|..|:.||.||...:||:|.|| :.|.|.:..
Zfish   328 EIEVNECTG--NPCRNGGSCTDMENT---YSCTCPPGFYGKNCELSAMTCADGPCFNGGRCADNP 387

  Fly   393 PGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGTRCETNIDDC 457
            .|      ||.|:||.||:|.||:.::|:||.:|
Zfish   388 DG------GYFCQCPTGYAGFNCEKKIDHCSSSP------------------------------- 415

  Fly   458 LGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFT 522
                |.||..|:|:||.|.|||..||.|.:|....|.|.:.||.|||||....:.|.|||..|:|
Zfish   416 ----CSNGARCVDLVNSYLCQCPDGFTGMNCDRAGDECSMYPCQNGGTCQEGASGYMCTCPPGYT 476

  Fly   523 GKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARA 587
            |::||..:..|...|||||.||..|.|.:.|.|.:|:.|:.|.....|.    |.|.|:.....|
Zfish   477 GRNCSSPVSRCQHNPCHNGATCHERNNRYVCACVSGYGGRNCQFLLPDR----ASQIGSDVPWTA 537

  Fly   588 DGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRK-RKRAQEKDDAEARKQNE--QNAVATMHHN 649
            .|   :.|:|:.       |:.|..|.||.|::.| ::|.::::|..|..:||  .|.....|.:
Zfish   538 VG---SGVLLVL-------LLVVACAVVVVCVRSKVQQRRRDREDEVANGENETINNLTNNCHRD 592

  Fly   650 G----SGVGVALASASLGGKTGSNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADEC 710
            .    |.||||...       ..|..:.|...:.::...|..:|..          ...|.||..
Zfish   593 KDLAVSVVGVAPVK-------NINKKIDFSSDHDDLSMTTEKRSYK----------TRHAPADYN 640

  Fly   711 LM--------------YGGYVASVADNNNANSDFC----------VAPLQRAKSQKQLNTDPTLM 751
            |:              :.|...::|   |..||.|          .:.....|.:|:|.:|.:..
Zfish   641 LVHEVKFEVKHEVKLEHAGKETTMA---NELSDSCEDIKCQSQQDSSECTEEKRRKRLKSDASEK 702

  Fly   752 HRGSPAGSSAKGASGGGPGAAEGKRISVLGEGSYCSQRWPSLAAAGVAGAC 802
            .:.|.:..|....|......::...:|:..| |.|:    |..|:....||
Zfish   703 SKYSESRYSESKYSESKYSESKYSDVSLYSE-SACA----SACASASTSAC 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	32/72 (44%)
		DSL	164..226	CDD:279722	33/61 (54%)
		EGF_CA	291..329	CDD:238011	25/37 (68%)
		EGF_CA	337..372	CDD:238011	15/34 (44%)
		EGF_CA	453..488	CDD:238011	14/34 (41%)
		EGF_CA	492..526	CDD:238011	16/33 (48%)
		EGF_CA	529..564	CDD:238011	14/34 (41%)
dla	NP_571029.2	MNNL	23..94	CDD:284966	32/72 (44%)
		DSL	161..223	CDD:128366	33/61 (54%)
		EGF_CA	290..328	CDD:238011	25/37 (68%)
		EGF_CA	331..366	CDD:238011	16/39 (41%)
		EGF_CA	<375..405	CDD:238011	14/35 (40%)
		EGF_CA	408..442	CDD:238011	18/68 (26%)
		EGF_CA	447..480	CDD:238011	16/32 (50%)
		EGF_CA	488..519	CDD:238011	13/30 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..722		7/33 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578035
Domainoid	1	1.000	113	1.000	Domainoid score	I6084
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	563	1.000	Inparanoid score	I1046
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0002026
OrthoInspector	1	1.000	-	-		otm24566
orthoMCL	1	0.900	-	-		OOG6_104568
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4539
SonicParanoid	1	1.000	-	-		X1332
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790