DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and dlc

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_571019.1	Gene:	dlc / 30120	ZFINID:	ZDB-GENE-000125-4	Length:	664	Species:	Danio rerio

Alignment Length:	761	Identity:	273/761 - (35%)
Similarity:	373/761 - (49%)	Gaps:	148/761 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KCLLTAFICFTVIVQVH---SSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFR 66
            :.|||   ||.:::..|   |||.|||::..|:      :....|.|.||         |:..||
Zfish     3 RVLLT---CFFILISSHLGKSSGVFELKVLSFT------STSSVCKGSSD---------CQIFFR 49

  Fly    67 VCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVE 131
            |||||.||.|.....||||..::.||..:|::.:..           |..||:|.|||..|||:|
Zfish    50 VCLKHSQALILPEPPCTYGTGMSEILSADSISSSAY-----------ISVPFNFKWPGIVSLIIE 103

  Fly   132 AWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKF 196
            .|:...:..:...|..:|.||..::.|.:|.:|..:....:.:.|.:.:||.||..|:|..|:.|
Zfish   104 TWNAETSDQSTENNNNMISRLATKRRLAISEDWSQDVHLGRQSQLRFSYRVVCDEFYHGEECSDF 168

  Fly   197 CRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNE 259
            ||||:|:|||..|...|..|||.||:||||..|.|..||  |:|:|:.|.:|.|::||:|.||:|
Zfish   169 CRPRNDTFGHFNCDAAGNRICLPGWKGDYCTEPICLSGCSEENGYCEAPGECKCRIGWEGPLCDE 233

  Fly   260 CVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYS 324
            |...|.|:|||||:|:.|.|.||||||:||:|||:||||:||:|..||.|||:|.|||.|.||:|
Zfish   234 CTRHPGCLHGTCNQPFQCTCKEGWGGLFCNEDLNFCTNHKPCRNDATCTNTGQGSYTCICKPGFS 298

  Fly   325 GDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGIC 388
            |.:||.|...||:  |||:|||:|.|:   :..|.|.|..|:.||.||...:||:|.|| :.|.|
Zfish   299 GKNCEIETNECDS--NPCKNGGSCNDQ---ENDYTCTCPQGFYGKNCEVSAMTCADGPCFNGGTC 358

  Fly   389 RNVRPGLGSKGQG-YQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGK---CICPAGFSGTR 449
            .       .||.| |.|.||.||.|.||:.::|.||.:||.|||.|...|.   |.|..||:|:|
Zfish   359 M-------EKGSGSYSCRCPPGYMGSNCEKKIDRCSSDPCANGGQCLDLGNKATCRCRPGFTGSR 416

  Fly   450 CETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQ 514
            ||||||||..:.|:|.|||:|.:                                      |.|.
Zfish   417 CETNIDDCSSNPCQNAGTCVDGI--------------------------------------NGYT 443

  Fly   515 CTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQY 579
            |||..||:||||.|..|.||..||.|||||....:...|.|..||.|.||:.:.
Zfish   444 CTCTLGFSGKDCRVRSDACSFMPCQNGGTCYTHFSGPVCQCPAGFMGTQCEYKQ----------- 497

  Fly   580 GATTQARADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVA 644
             ..|...:..|..|.:|...:..:.:.|| :.||.||....|               ||.:.:..
Zfish   498 -KPTPVNSPALPAALIVSFTLGLITLTLV-ICAAIVVLRQMR---------------QNHKASST 545

  Fly   645 TMHHNGSGVG--VALASASLGGKTGSNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAA 707
            |:.:|...|.  ::|:..|..|:  ........||         ...|:|...:..:.:....::
Zfish   546 TVRNNLDSVNNRISLSPTSPLGR--EKEAFLIPGG---------PFKVSNKDMALRSTSVDTHSS 599

  Fly   708 DECLMYGGYVASVADNN--------------NANSDFCVAPLQRAK 739
            |:    ..|...:.|.|              |:.|...|.||...|
Zfish   600 DK----SNYKQKMVDYNLSIDEKHTNNKLEKNSESTLLVPPLNYPK 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	27/72 (38%)
		DSL	164..226	CDD:279722	27/61 (44%)
		EGF_CA	291..329	CDD:238011	24/37 (65%)
		EGF_CA	337..372	CDD:238011	14/34 (41%)
		EGF_CA	453..488	CDD:238011	11/34 (32%)
		EGF_CA	492..526	CDD:238011	9/33 (27%)
		EGF_CA	529..564	CDD:238011	15/34 (44%)
dlc	NP_571019.1	MNNL	21..79	CDD:284966	27/72 (38%)
		DSL	136..198	CDD:279722	27/61 (44%)
		EGF_CA	265..303	CDD:238011	24/37 (65%)
		EGF_CA	307..341	CDD:238011	16/38 (42%)
		EGF_CA	<350..380	CDD:238011	15/36 (42%)
		EGF_CA	383..418	CDD:238011	16/34 (47%)
		EGF_CA	420..455	CDD:238011	20/72 (28%)
		EGF_CA	<466..494	CDD:238011	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578043
Domainoid	1	1.000	113	1.000	Domainoid score	I6084
eggNOG	1	0.900	-	-		E33208_3BEE5
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	563	1.000	Inparanoid score	I1046
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0002026
OrthoInspector	1	1.000	-	-		otm24566
orthoMCL	1	0.900	-	-		OOG6_104568
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1332
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.660