DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and Jag2

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	XP_038967750.1	Gene:	Jag2 / 29147	RGDID:	2938	Length:	1247	Species:	Rattus norvegicus

Alignment Length:	870	Identity:	274/870 - (31%)
Similarity:	360/870 - (41%)	Gaps:	218/870 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KCLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLG----SCKTRF 65
            :.||...:|   :......|.|||:|....|.:|....|.||.|  ||.|.:..|    .|.|..
  Rat    12 RLLLLLVLC---VQATRPMGYFELQLSALRNVNGELLSGACCDG--DGRTTRAGGCGRDECDTYV 71

  Fly    66 RVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDA--------QRFQNKGFTNP--IQFPFSF 120
            |||||.|||.:..|..|:||...||:||.||..|..|        .|.:..|..:|  :..||.|
  Rat    72 RVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPPAGAAGDRARARSRTGGHQDPGLVVIPFQF 136

  Fly   121 SWPGTFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCD 185
            :||.:|:||||||...|::  ....:|||:|:....::.....||:.........||...||.||
  Rat   137 AWPRSFTLIVEAWDWDNDT--TPDEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCD 199

  Fly   186 LNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVC 248
            .|||.:.|.||||||:|.|||.||.:.|...|:.||.|..|....|.:||.  ||.|..|.:|.|
  Rat   200 ENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRC 264

  Fly   249 QLGWKGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEG 313
            ..||:|..|:|||..|.|:||:|.:||.|.|...||||.|::|||||.:|.||.|||||.|....
  Rat   265 SYGWQGKFCDECVPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCINAEPD 329

  Fly   314 LYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTC 378
            .|.|.|..||.|.:||...::|.:  |||.|||:|.:   ..:|::|||.:||||..|...:..|
  Rat   330 QYLCACPDGYLGKNCERAEHACAS--NPCANGGSCHE---VLSGFECHCPSGWSGPTCALDIDEC 389

  Fly   379 SDKPCHQ-GICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQ---PSGKC 439
            :..||.. |.|.:       :..|::|.||..:.|..|.|..:.|...||:|..||:   ....|
  Rat   390 ASNPCAAGGTCVD-------QVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYC 447

  Fly   440 ICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSK------------- 491
            .|..|:.|..|..||:||.| ||::||||.|:||.|:|.|..||.|.||..:
  Rat   448 DCLPGWKGANCHININDCHG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYYKCASSPCRRGG 511

  Fly   492 -------------------------VDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSV--- 528
                                     ||||...||.||..|.||.:||.|.|...|.||:|||
  Rat   512 ICEDLVDGFRCHCPRGLSGPLCEVDVDLCEPNPCLNGARCYNLEDDYYCACPEDFGGKNCSVPRE 576

  Fly   529 -----------------------------------------------------------DIDECS 534
                                                                       :||:|.
  Rat   577 TCPGGACRVIDGCGFEAGSRAHGAAPSGVCGPHGHCVSLPGGNFSCICDSGFTGTYCHENIDDCM 641

  Fly   535 SGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTNAQVVLIA 599
            ..||.|||||::.|:||.|.|.:|:.|:.||....|.:....|..|     |...|.|.
  Rat   642 GQPCRNGGTCIDEVDSFRCFCPSGWEGELCDINPNDCLPDPCHSRG-----RCYDLVND------ 695

  Fly   600 VFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVGVALASASLGG 664
                            .:|:         .||....|        |.|..         ......
  Rat   696 ----------------FYCV---------CDDGWKGK--------TCHSR---------EFQCDA 718

  Fly   665 KTGSNSGLTFDGGNP--------------NIIKNTWDKSVNNICASAAAAAAAAAAADECLMYGG 715
            .|.||.|..:|.|:.              .|.||:  ..|.|.|.:......:..:. .|:...|
  Rat   719 YTCSNGGTCYDSGDTFRCACPPGWKGSTCTIAKNS--SCVPNPCVNGGTCVGSGDSF-SCICRDG 780

  Fly   716 YVASVADNNN--------ANSDFCV 732
            :......:|.        .|...||
  Rat   781 WEGRTCTHNTNDCNPLPCYNGGICV 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	33/76 (43%)
		DSL	164..226	CDD:279722	29/61 (48%)
		EGF_CA	291..329	CDD:238011	20/37 (54%)
		EGF_CA	337..372	CDD:238011	15/34 (44%)
		EGF_CA	453..488	CDD:238011	20/34 (59%)
		EGF_CA	492..526	CDD:238011	18/33 (55%)
		EGF_CA	529..564	CDD:238011	17/34 (50%)
Jag2	XP_038967750.1	MNNL	28..103	CDD:400141	34/76 (45%)
		DSL	178..240	CDD:396134	29/61 (48%)
		EGF_CA	307..345	CDD:238011	20/37 (54%)
		EGF	351..381	CDD:394967	16/34 (47%)
		EGF_CA	385..421	CDD:238011	10/42 (24%)
		EGF_CA	423..458	CDD:238011	10/34 (29%)
		EGF_CA	461..496	CDD:238011	21/35 (60%)
		EGF_CA	502..534	CDD:238011	0/31 (0%)
		EGF_CA	536..571	CDD:238011	18/34 (53%)
		EGF_CA	636..671	CDD:238011	17/34 (50%)
		EGF_CA	676..709	CDD:238011	10/76 (13%)
		EGF	716..746	CDD:394967	6/29 (21%)
		EGF_CA	757..787	CDD:238011	4/30 (13%)
		EGF_CA	<797..824	CDD:238011	3/9 (33%)
		EGF_CA	827..863	CDD:238011
		VWC_out	872..943	CDD:214565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11589
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920