DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dl and Jag1

DIOPT Version :9

Sequence 1:NP_001247193.1 Gene:Dl / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_062020.2 Gene:Jag1 / 29146 RGDID:2937 Length:1219 Species:Rattus norvegicus


Alignment Length:746 Identity:263/746 - (35%)
Similarity:357/746 - (47%) Gaps:123/746 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 CLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCL-GSCKTRFRVCL 69
            |.|.|.:|       .:||.|||.:....|.:|....|.||.|..:....||. ..|.|.|:|||
  Rat    22 CALRAKVC-------GASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCL 79

  Fly    70 KHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWH 134
            |.||:.:.....|::|...||::|.|:.|| .|.|..::   |.|..||||:||.:::|:||||.
  Rat    80 KEYQSRVTAGGPCSFGSGSTPVIGGNTFNL-KASRGNDR---NRIVLPFSFAWPRSYTLLVEAWD 140

  Fly   135 DTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRP 199
            .:|::....:   :|::.....::..|.:|:|.|..:.....||..|||||.:|||.||.|||||
  Rat   141 SSNDTIQPDS---IIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRP 202

  Fly   200 RDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNECVL 262
            |||.|||..|.:.|...|:.||.|..|:...|.:||  :||.|..|..|.||.||:|..|::|:.
  Rat   203 RDDFFGHYACDQNGNKTCMEGWMGPECNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIP 267

  Fly   263 EPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDD 327
            .|.|:|||||:||.|:|...|||..|::|||||..|:||.|.|||.|||...|.|.|..||||.:
  Rat   268 HPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPN 332

  Fly   328 CENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNV 391
            ||...::|.:|  ||.|.|:|   ..|.:|::|.|:.||:|..|...:..||...| |.|.|:::
  Rat   333 CEIAEHACLSD--PCHNRGSC---KETSSGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL 392

  Fly   392 RPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQ---PSGKCICPAGFSGTRCETN 453
                   ..|::|.||..::|..|.|..:.|...||:|..||:   .|..|.|..|:.|..|:.|
  Rat   393 -------VNGFKCVCPPQWTGKTCQLDANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCDIN 450

  Fly   454 IDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCR 518
            |:|||| ||:|..:|.|:||.|||.|.||:.|.||...:|.|...||.|||.|.|..|.:||.|.
  Rat   451 INDCLG-QCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCP 514

  Fly   519 AGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATT 583
            .||:|..|.:|||.|...||.||..|.||.:.:.|.|...:.||.|..         ...:..||
  Rat   515 TGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSH---------LKDHCRTT 570

  Fly   584 QARADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATMHH 648
            ...                       ||.:|.|                            .|..
  Rat   571 PCE-----------------------VIDSCTV----------------------------AMAS 584

  Fly   649 NGSGVGVALASASL-----------GGKTGSNSGLTFDG-----------GNPNIIKNTWDKSVN 691
            |.:..||...|:::           |||...:....|.|           |||.....|....||
  Rat   585 NDTPEGVRYISSNVCGPHGKCKSESGGKFTCDCNKGFTGTYCHENINDCEGNPCTNGGTCIDGVN 649

  Fly   692 N---ICASAAAAAAAAAAADECLM----YGG 715
            :   ||:.....|......::|..    |||
  Rat   650 SYKCICSDGWEGAHCENNINDCSQNPCHYGG 680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DlNP_001247193.1 MNNL 23..96 CDD:284966 27/73 (37%)
DSL 164..226 CDD:279722 32/61 (52%)
EGF_CA 291..329 CDD:238011 22/37 (59%)
EGF_CA 337..372 CDD:238011 13/34 (38%)
EGF_CA 453..488 CDD:238011 20/34 (59%)
EGF_CA 492..526 CDD:238011 16/33 (48%)
EGF_CA 529..564 CDD:238011 15/34 (44%)
Jag1NP_062020.2 MNNL 32..107 CDD:400141 28/74 (38%)
DSL 167..229 CDD:396134 32/61 (52%)
Important for interaction with NOTCH1. /evidence=ECO:0000250 199..207 7/7 (100%)
EGF_CA 296..334 CDD:238011 22/37 (59%)
EGF 340..370 CDD:394967 14/34 (41%)
EGF_CA 374..410 CDD:238011 11/42 (26%)
EGF_CA 412..447 CDD:238011 11/34 (32%)
EGF_CA 450..485 CDD:238011 21/35 (60%)
EGF_CA 487..523 CDD:238011 16/35 (46%)
EGF_CA 525..560 CDD:238011 15/34 (44%)
EGF_CA 629..665 CDD:238011 9/35 (26%)
EGF_CA 667..702 CDD:238011 4/14 (29%)
EGF_CA <714..740 CDD:238011
EGF 748..777 CDD:394967
EGF_CA 782..817 CDD:238011
EGF_CA 820..855 CDD:238011
VWC_out 863..930 CDD:214565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1182..1219
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338542
Domainoid 1 1.000 48 1.000 Domainoid score I11589
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D197806at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.850

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