DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dl and SNED1

DIOPT Version :9

Sequence 1:NP_001247193.1 Gene:Dl / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:XP_011509233.1 Gene:SNED1 / 25992 HGNCID:24696 Length:1437 Species:Homo sapiens


Alignment Length:665 Identity:177/665 - (26%)
Similarity:249/665 - (37%) Gaps:228/665 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 HYQATIDTT-SQCTYGDVITPILG---ENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVE 131
            :|::.:.|| :..:.|...|.:.|   :...|..|.||:              ||.||:.:..:.
Human   211 NYESIVWTTGTHASSGGNATGLGGIAAQAGFNAGDGQRY--------------FSIPGSRTADMA 261

  Fly   132 AWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQY--------TSLEYDFRVTCDLNY 188
            ....|.|.|                   |...|.....::|.        ||:....| .| || 
Human   262 EVETTTNVG-------------------VPGRWAFRIDDAQVRVGGCGHTTSVCLALR-PC-LN- 304

  Fly   189 YGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHI------------------------- 228
             |..|...|...:.|:   |||      ||:|:.|..||:                         
Human   305 -GGKCIDDCVTGNPSY---TCS------CLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRC 359

  Fly   229 --------PKC--------AKGCEH-GHCDKPN---QCVCQLGWKGALC----NECVLEPNCIH- 268
                    |.|        .|.|:| |.|...|   .||||.|:.||.|    ::|..:| |:: 
Human   360 QCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDP-CLNG 423

  Fly   269 GTC-----NKPWTCICNEGWGGLYCNQD----LNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYS 324
            |:|     |  :||:|.|.:.||.|...    .:.|.: .||.|||||.:..:| |.|:|..|:.
Human   424 GSCVDLVGN--YTCLCAEPFKGLRCETGDHPVPDACLS-APCHNGGTCVDADQG-YVCECPEGFM 484

  Fly   325 GDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLT--------CSD- 380
            |.||...:    .|...|:|||.|:....|    .|.|..|:.|.:||.::..        |.| 
Human   485 GLDCRERV----PDDCECRNGGRCLGANTT----LCQCPLGFFGLLCEFEITAMPCNMNTQCPDG 541

  Fly   381 -------------------------KPCHQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLD 420
                                     .||....|.| .....:....|.||||.|:.|.:|:....
Human   542 GYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFN-GGSCDAHDDSYTCECPRGFHGKHCEKARP 605

  Fly   421 N-CSPNPCINGGSCQPSG---KCICPAGFSGTRCET-NIDDCLGHQCENGGTCIDMVNQYRCQCV 480
            : ||..||.|||:|:.:|   .|.||..|:|..||. ..|.|....|.|||||...:.:|:|.|.
Human   606 HLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCP 670

  Fly   481 PGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCS------------------ 527
            |||.|.||......|...||.|||||.:.:.|:.|.|:||:.|:.|.                  
Human   671 PGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRF 735

  Fly   528 ----------------------------------------VDIDECSSGPCHNGGTCMNRVNSFE 552
                                                    ::||||.|.||.:||:|.:||..:.
Human   736 NGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYL 800

  Fly   553 CVCANGFRGKQCDEE 567
            |:|:.|:.|..|:.|
Human   801 CLCSTGYEGAHCELE 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DlNP_001247193.1 MNNL 23..96 CDD:284966 6/28 (21%)
DSL 164..226 CDD:279722 19/69 (28%)
EGF_CA 291..329 CDD:238011 15/41 (37%)
EGF_CA 337..372 CDD:238011 11/34 (32%)
EGF_CA 453..488 CDD:238011 15/34 (44%)
EGF_CA 492..526 CDD:238011 14/33 (42%)
EGF_CA 529..564 CDD:238011 16/34 (47%)
SNED1XP_011509233.1 NIDO 128..284 CDD:214712 19/105 (18%)
EGF_CA 296..332 CDD:238011 15/48 (31%)
EGF_CA 335..371 CDD:238011 1/35 (3%)
EGF_CA 411..447 CDD:238011 12/38 (32%)
EGF_CA 455..488 CDD:238011 14/34 (41%)
EGF_CA 569..601 CDD:238011 10/32 (31%)
EGF_CA 609..640 CDD:238011 13/30 (43%)
EGF_CA 645..679 CDD:238011 16/33 (48%)
EGF_CA <688..717 CDD:238011 13/28 (46%)
Sushi 722..775 CDD:278512 0/52 (0%)
EGF_CA 778..813 CDD:238011 16/34 (47%)
EGF_CA 817..851 CDD:238011
EGF_CA 854..889 CDD:238011
fn3 932..1012 CDD:278470
fn3 1031..1106 CDD:278470
fn3 1130..1208 CDD:278470
EGF_CA 1336..1367 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D197806at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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