DRSC/TRiP Functional Genomics Resources

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Protein Alignment Delta and Dner

DIOPT Version :10

Sequence 1:NP_477264.1 Gene:Delta / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_690879.1 Gene:Dner / 227325 MGIID:2152889 Length:737 Species:Mus musculus


Alignment Length:577 Identity:164/577 - (28%)
Similarity:252/577 - (43%) Gaps:103/577 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 SW-PGTFSLIVE-AWHDTN-----NSGNARTNKLLIQRLLVQQVLEVSSE-------------WK 165
            :| |.|...:|| .|....     ..|||.:|.....||:..:|.:.:|.             ||
Mouse   177 TWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDANSLLILLWK 241

  Fly   166 TNKSESQYTSLEYDFRVTCDLNYYGS----------GCAKFCRPRDDSFGHSTCSETGEIICLTG 220
            ...:..|..|| .|.|....|...|.          |...|....:||...|..:....::....
Mouse   242 VTATGFQQCSL-IDGRSVTPLQAPGGLVLLEEMLALGPNHFIGFVNDSVAKSIVALRLTLVVKAS 305

  Fly   221 WQGDYCHIPKCAKGCEHGHCDKPNQCVCQLGWKGALCNECVLEPNCIHGTCNKPWTCICNEGWGG 285
                     .|..|..|.     |...|  ..||    :|..:|:      ...::|.|.:.:.|
Mouse   306 ---------NCVPGDSHS-----NDLEC--SGKG----KCATKPS------EATFSCTCQDQYIG 344

  Fly   286 LYCNQDLNYCTNHRPCKNGGTCFNTGE----GLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGG 346
            .:| ::.:.| ..:||:|..:|.:..|    ..:||.|.|||:|:.|:::|..|..|  ||:||.
Mouse   345 TFC-EEFDAC-QRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLD--PCRNGA 405

  Fly   347 TCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNVRPGLGSKGQGYQCECPIGY 410
            ||:.   :.:|:.|.|..|:.|..|||||..|...|| :.|.|.       ..|..:.|.|..|:
Mouse   406 TCVS---SLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCY-------VDGVHFTCSCSPGF 460

  Fly   411 SGPNCDLQLDNCSPNPCINGGSCQPSG---KCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMV 472
            :||.|...:|.|:.:||.: |.|:..|   ||:|..|:.|..||...::||...|.|..||.|::
Mouse   461 TGPTCAQLVDFCALSPCAH-GMCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLI 524

  Fly   473 NQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGP 537
            |.|.|.|:..:.||||....|.|....|.|||||.:...:..|.|..||||::|.:||:||.|.|
Mouse   525 NGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNP 589

  Fly   538 CHNGGTCMNRVNSFECVCANGFRGKQCD-EESYDSVTFDAHQYGATTQARADGLTN----AQVVL 597
            ||:.|||:::.|.:.|.|.:|:.|..|: ...:.|    .|.        |:.|||    :..::
Mouse   590 CHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKS----GHM--------AESLTNMPRHSLYII 642

  Fly   598 IAVFSVA---MPLVAVIAACVVFCMK---RKRKRAQEKDDAEARKQNEQNAVATMHH 648
            |....||   |.::.::..|.:..::   ..|...:|..:..:......||:|::.|
Mouse   643 IGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRH 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DeltaNP_477264.1 MNNL 23..182 CDD:462222 20/80 (25%)
DSL 164..226 CDD:128366 14/71 (20%)
EGF_CA 291..329 CDD:238011 13/41 (32%)
EGF_CA 337..372 CDD:238011 12/34 (35%)
EGF_CA 453..488 CDD:238011 13/34 (38%)
EGF_CA 492..526 CDD:238011 14/33 (42%)
EGF_CA 529..564 CDD:238011 16/34 (47%)
DnerNP_690879.1 Interaction with NOTCH1. /evidence=ECO:0000269|PubMed:15965470 44..133
EGF_CA 393..428 CDD:238011 14/39 (36%)
EGF_CA 431..465 CDD:238011 12/40 (30%)
EGF_CA 507..541 CDD:238011 14/33 (42%)
EGF_CA 581..617 CDD:238011 16/35 (46%)
DNER_C 635..737 CDD:437162 11/65 (17%)
Interaction with AP1G1 and somatodendritic targeting. /evidence=ECO:0000269|PubMed:11950833 677..680 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

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