DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and dsl-4

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_001359594.1	Gene:	dsl-4 / 184563	WormBaseID:	WBGene00001106	Length:	368	Species:	Caenorhabditis elegans

Alignment Length:	541	Identity:	127/541 - (23%)
Similarity:	182/541 - (33%)	Gaps:	201/541 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKH 71
            ||..|: |.|.:.|.:.|:.|:|::               ||.|            ...||   |
Worm     3 LLLLFL-FNVFINVRTHGNTEIRIQ---------------SGIS------------VYVRV---H 36

  Fly    72 YQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVE-AWHD 135
            :         |||....:..|.:|.:.......|       |..|...|:.|...::|.. :.:|
Worm    37 F---------CTYSTRCSSPLWKNIIPFEVIPEF-------PFVFEEYFTRPTLPNVIFTISIYD 85

  Fly   136 TNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPR 200
            .|:.     ..|.:::::|......|:.....|::|   .|.:..|..||.|:....|:.||:.|
Worm    86 INDE-----EPLGLEQIVVPLTRHFSNFTVHTKNDS---FLHFAVRNVCDENWRTHSCSIFCKDR 142

  Fly   201 DDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCEHGHCDKPNQCVCQLGWKGALCNECVLEPN 265
            .||  ...|.:.....|..|:.|..|....|...|.:
Worm   143 SDS--KFKCDDDDGYKCAPGYSGPNCDKVDCPFNCHN---------------------------- 177

  Fly   266 CIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFN-TGEGLYTCKCAPGYSGDDCE 329
              ||:|..|..|:|::|:.|.||    .||.....||:|....| .|...|||:|..||:||:.:
Worm   178 --HGSCEVPGKCMCSQGFFGTYC----EYCKPSTTCKHGAVLVNELGCHPYTCRCFEGYAGDNGD 236

  Fly   330 NEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQGICRNVRPG 394
            .:      ||                    |:.|                 |||..|
Worm   237 KD------DV--------------------CYYA-----------------KPCRHG-------- 250

  Fly   395 LGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGTRCETNID--DC 457
                                      ||..|..::||.     :||||..|.|.|||..|.  ||
Worm   251 --------------------------NCVSNVTVSGGF-----ECICPKAFGGRRCEKRIARWDC 284

  Fly   458 LGH-QCENGGTC--IDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRA 519
            ... .|:|.|.|  :|.::  ||:|..||.|.||..|          ...|||...      ||.
Worm   285 SDEGYCQNKGVCSFVDGIS--RCRCAVGFTGKHCERK----------TAKTCLKKK------CRE 331

  Fly   520 GFTGKDCSVDIDECSSGPCHN 540
            ||.   |.:|..:..:.||.|
Worm   332 GFI---CIIDNKKTGTMPCFN 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	13/72 (18%)
		DSL	164..226	CDD:279722	17/61 (28%)
		EGF_CA	291..329	CDD:238011	15/38 (39%)
		EGF_CA	337..372	CDD:238011	4/34 (12%)
		EGF_CA	453..488	CDD:238011	14/39 (36%)
		EGF_CA	492..526	CDD:238011	7/33 (21%)
		EGF_CA	529..564	CDD:238011	4/12 (33%)
dsl-4	NP_001359594.1	DSL	110..166	CDD:366627	17/60 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1332
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.870