DRSC/TRiP Functional Genomics Resources

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Protein Alignment Delta and JAG1

DIOPT Version :10

Sequence 1:NP_477264.1 Gene:Delta / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_000205.1 Gene:JAG1 / 182 HGNCID:6188 Length:1218 Species:Homo sapiens


Alignment Length:585 Identity:238/585 - (40%)
Similarity:319/585 - (54%) Gaps:44/585 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 CLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCL-GSCKTRFRVCL 69
            |.|.|.:|       .:||.|||.:....|.:|....|.||.|..:....||. ..|.|.|:|||
Human    22 CALRAKVC-------GASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCL 79

  Fly    70 KHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWH 134
            |.||:.:.....|::|...||::|.|:.|| .|.|..::   |.|..||||:||.:::|:||||.
Human    80 KEYQSRVTAGGPCSFGSGSTPVIGGNTFNL-KASRGNDR---NRIVLPFSFAWPRSYTLLVEAWD 140

  Fly   135 DTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRP 199
            .:|::....:   :|::.....::..|.:|:|.|..:.....||..|||||..|||.||.|||||
Human   141 SSNDTVQPDS---IIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRP 202

  Fly   200 RDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNECVL 262
            |||.|||..|.:.|...|:.||.|..|:...|.:||  :||.|..|..|.||.||:|..|::|:.
Human   203 RDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIP 267

  Fly   263 EPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDD 327
            .|.|:||.||:||.|:|...|||..|::|||||..|:||.|||||.|||...|.|.|..||||.:
Human   268 HPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPN 332

  Fly   328 CENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNV 391
            ||...::|.:|  ||.|.|:|   ..|..|::|.|:.||:|..|...:..||...| |.|.|:::
Human   333 CEIAEHACLSD--PCHNRGSC---KETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL 392

  Fly   392 RPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQ---PSGKCICPAGFSGTRCETN 453
                   ..|::|.||..::|..|.|..:.|...||:|..||:   .|..|.|..|:.|..|:.|
Human   393 -------VNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDIN 450

  Fly   454 IDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCR 518
            |:|||| ||:|..:|.|:||.|||.|.||:.|.||...:|.|...||.|||.|.|..|.:||.|.
Human   451 INDCLG-QCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCP 514

  Fly   519 AGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDE----------ESYDSVT 573
            .||:|..|.:|||.|...||.||..|.||.:.:.|.|...:.||.|..          |..||.|
Human   515 TGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCT 579

  Fly   574  573
            Human   580  579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DeltaNP_477264.1 MNNL 23..182 CDD:462222 53/159 (33%)
DSL 164..226 CDD:128366 32/61 (52%)
EGF_CA 291..329 CDD:238011 23/37 (62%)
EGF_CA 337..372 CDD:238011 13/34 (38%)
EGF_CA 453..488 CDD:238011 20/34 (59%)
EGF_CA 492..526 CDD:238011 16/33 (48%)
EGF_CA 529..564 CDD:238011 15/34 (44%)
JAG1NP_000205.1 MNNL 32..185 CDD:462222 53/159 (33%)
DSL 167..229 CDD:128366 32/61 (52%)
Important for interaction with NOTCH1. /evidence=ECO:0000269|PubMed:18660822 199..207 7/7 (100%)
EGF_CA 296..334 CDD:238011 23/37 (62%)
EGF 340..370 CDD:394967 14/34 (41%)
EGF_CA 374..410 CDD:238011 11/42 (26%)
EGF_CA 412..447 CDD:238011 11/34 (32%)
EGF_CA 450..485 CDD:238011 21/35 (60%)
EGF_CA 487..523 CDD:238011 16/35 (46%)
EGF_CA 525..560 CDD:238011 15/34 (44%)
EGF_CA 629..665 CDD:238011
EGF_CA 667..702 CDD:238011
EGF 748..777 CDD:394967
EGF_CA 782..817 CDD:238011
EGF_CA 820..856 CDD:238011
VWC_out 863..930 CDD:214565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1152..1218
Blue background indicates that the domain is not in the aligned region.

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