Protein Alignment Delta and apx-1

DIOPT Version :10

• Sequence 1: NP_477264.1
• Gene: Delta / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: NP_503882.2
• Gene: apx-1 / 178759
• WormBaseID: WBGene00000168
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 707
• Identity: 146/707 - (20%)
• Similarity: 221/707 - (31%)
• Gaps: 283/707 - (40%)

  Fly     7 LLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKH 71
            |.|.|:|  :|.....||:.||                            .:.|.:|..
 Worm     8 LTTIFLC--IISSATGSGTIEL----------------------------LISSPQTVL------ 36

  Fly    72 YQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWHDT 136
            .:.|:....:|...|           :|:.|::.|.:   .|::|       ||     ..:|
 Worm    37 VEPTVCANFECAAPD-----------DLSLARKVQRR---VPLRF-------GT-----GQYH-- 73

  Fly   137 NNSGNARTNKLLIQRLLVQQVLEV----------SSEWKTNK----SESQYTSLEYDFRVTCDLN 187
               |.||....|..:::.....|:          .:||.::.    ..|:..::....|..|..|
 Worm    74 ---GEARERIDLHLKIIEPTSNEILALQHHRPAADTEWNSDAPIVIETSRGFNVTVQLRNLCSSN 135

  Fly   188 YYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCEH-GHCDKPNQCVCQLG 251
            |:|..|.::|..  ::..|..||..|...|..||.|:.|..|.||.||.: |.|..||||.|..|
 Worm   136 YHGKRCNRYCIA--NAKLHWECSTHGVRRCSAGWSGEDCSNPICAGGCSNRGRCVAPNQCSCADG 198

  Fly   252 WKGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYT 316
            :.|..|.:|:....|::|.                        |.|..|              .|
 Worm   199 FNGTRCEQCLPRAGCVNGD------------------------CVNETP--------------NT 225

  Fly   317 CKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDK 381
            |||..|:.||.|:.:|..|..: .||.|||.|..:..:.|||||||...:.|.
 Worm   226 CKCRDGFIGDRCDIDIKICSLE-KPCANGGICSIDSSSSTGYKCHCPFEFVGS------------ 277

  Fly   382 PCHQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFS 446
                                 ||:.|:                                     |
 Worm   278 ---------------------QCKTPL-------------------------------------S 284

  Fly   447 GTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNN 511
            ..||...      |.|:|||.||.|.                                     :.
 Worm   285 KVRCSAE------HVCKNGGACISMD-------------------------------------DT 306

  Fly   512 DYQCTCRAGFTGKDCSV-DIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFD 575
            :.||.||.||:||.|.: :..:||:..|..|.||  :::....:|...           |.:...
 Worm   307 NIQCKCRRGFSGKFCEIGNHGDCSAMRCSAGETC--QISGDFAICVEN-----------DELLLT 358

  Fly   576 AHQYGATTQA---------------RADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCM------ 619
            .::...||::               .:|.|   |:.|||...|...:..:..|.|.|..
 Worm   359 TNKPAETTKSVEKWREPRKTANDEQASDEL---QLRLIAAICVLFSVCVIGLALVSFFFYMHSFS 420

  Fly   620 KRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVG------VALASASLGGKTGSNS 670
            |.|...:|:...:..........::|   ..||.|      ..:.|...|...||:|
 Worm   421 KWKHPSSQQAGGSTILPTTTSIPMST---TSSGTGSPVYKVCIIDSEHRGNAPGSSS 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Delta	NP_477264.1	MNNL	23..182	CDD:462222	25/172 (15%)
		DSL	164..226	CDD:128366	17/65 (26%)
		EGF_CA	291..329	CDD:238011	10/37 (27%)
		EGF_CA	337..372	CDD:238011	14/34 (41%)
		EGF_CA	453..488	CDD:238011	8/34 (24%)
		EGF_CA	492..526	CDD:238011	8/33 (24%)
		EGF_CA	529..564	CDD:238011	7/34 (21%)
apx-1	NP_503882.2	DSL	108..172	CDD:473190	17/65 (26%)