DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and lin-12

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_499007.1	Gene:	lin-12 / 176282	WormBaseID:	WBGene00003001	Length:	1429	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	182/710 - (25%)
Similarity:	258/710 - (36%)	Gaps:	257/710 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 DFRV------TCDLN------------YYGSGCAK--FCRPRDDSFGHSTCSETGEII------- 216
            |:|:      .||:|            |.|..|..  :|.|       |.|...|:.|
Worm    80 DYRMETCVCKDCDINGNSLLKPSCPSGYGGDDCKTQGWCYP-------SVCMNGGQCIGAGNRAK 137

  Fly   217 --CLTGWQGDYCHI-----------------------------------PKCAKG---------- 234
              |..|::|:.|.:                                   |.|.|.
Worm   138 CACPDGFKGERCELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQ 202

  Fly   235 ------------------CEH-GHCDK-PNQCVCQLGWKGALC------NECVLEPNCIHGTC-- 271
                              |:: |.||| .::|.|..|:.|:.|      :.|...| |.||.|
Worm   203 PVCFLEISADHPDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNP-CSHGVCIS 266

  Fly   272 -NKPWTCICNEGWGGLYCNQDLNYCTNHR-----PCKNG-------------------------- 304
             :..:.|||::|:.|.||.:..:.|.|::     .|.||
Worm   267 FSGGFQCICDDGYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIP 331

  Fly   305 -----GTCFNT--GEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHC 362
                 |||.::  .|..:.|:|.|||.|..||.:...|.:: |.|.|.|||::.|.:   ::|.|
Worm   332 DICNHGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSE-NMCLNNGTCVNLPGS---FRCDC 392

  Fly   363 ANGWSGKMCEEKVLTCSDKPC-----------HQGI--CRNVRPGLGSKGQGYQCECPIGYSGPN 414
            |.|:.||.|:|.:..|.|..|           |..:  |:|     |..|:..:.|||||:.|..
Worm   393 ARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKN-----GFIGKRCEKECPIGFGGVR 452

  Fly   415 CDLQLD--NCS--PNPCINGGSCQPSGKCICPAGFSGTRCETNIDD---------CLGHQCENGG 466
            |||:|:  .||  ...|.|||.|. ||.|:||..|:|.:||.|..:         ||...|.|..
Worm   453 CDLRLEIGICSRQGGKCFNGGKCL-SGFCVCPPDFTGNQCEVNRKNGKSSLSENLCLSDPCMNNA 516

  Fly   467 TCIDMVNQ--YRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVD 529
            ||||:...  |.|.|..||.|..|....||||..||:|||.|......:.|.|..||.|..|..:
Worm   517 TCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQE 581

  Fly   530 -IDECSSGPCHNGGTCMN-RVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTN 592
             :..|....|.|||.|:| .....:|.|:.||.|.:|:|                 :....|.|.
Worm   582 KMFRCLKSTCQNGGVCINEEEKGRKCECSYGFSGARCEE-----------------KINLTGFTE 629

  Fly   593 AQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVGVAL 657
            ...:|.:|                 |.|||.          :.:.|:.|..|..::
Worm   630 KDSLLRSV-----------------CEKRKC----------SERANDGNCDADCNY--------- 658

  Fly   658 ASASLGGKTGSNSGLTFDGGNPNIIKNTWDK-SVNNICAS--AAAAAAAAAAADECLMYG 714
                        :...||||:.:..:..:.| ...|:||.  |......|...:|||..|
Worm   659 ------------AACKFDGGDCSGKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDG 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966
		DSL	164..226	CDD:279722	17/75 (23%)
		EGF_CA	291..329	CDD:238011	15/75 (20%)
		EGF_CA	337..372	CDD:238011	13/34 (38%)
		EGF_CA	453..488	CDD:238011	15/45 (33%)
		EGF_CA	492..526	CDD:238011	15/33 (45%)
		EGF_CA	529..564	CDD:238011	12/36 (33%)
lin-12	NP_499007.1	EGF_CA	152..189	CDD:238011	1/36 (3%)
		EGF_CA	252..285	CDD:238011	12/33 (36%)
		EGF_CA	293..323	CDD:238011	4/29 (14%)
		EGF_CA	365..401	CDD:238011	14/39 (36%)
		EGF_CA	505..541	CDD:238011	14/35 (40%)
		EGF_CA	545..579	CDD:238011	15/33 (45%)
		NL	635..668	CDD:197463	12/80 (15%)
		Notch	675..709	CDD:278494	10/32 (31%)
		Notch	722..750	CDD:278494
		NOD	754..804	CDD:284282
		NODP	842..898	CDD:284987
		ANK	1046..1186	CDD:238125
		ANK repeat	1052..1091	CDD:293786
		Ank_4	1053..1113	CDD:290365
		ANK repeat	1093..1124	CDD:293786
		Ank_4	1094..1147	CDD:290365
		ANK repeat	1126..1160	CDD:293786
		ANK	1160..1292	CDD:238125
		ANK repeat	1162..1201	CDD:293786
		Ank_2	1167..1271	CDD:289560
		ANK repeat	1203..1238	CDD:293786
		ANK repeat	1240..1271	CDD:293786
		Pap_E4	1306..>1373	CDD:280813
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910