DRSC/TRiP Functional Genomics Resources

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Protein Alignment Delta and Jag1

DIOPT Version :10

Sequence 1:NP_477264.1 Gene:Delta / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_038850.1 Gene:Jag1 / 16449 MGIID:1095416 Length:1218 Species:Mus musculus


Alignment Length:585 Identity:238/585 - (40%)
Similarity:321/585 - (54%) Gaps:44/585 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 CLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCL-GSCKTRFRVCL 69
            |.|.|.:|       .:||.|||.:....|.:|....|.||.|..:....||. ..|.|.|:|||
Mouse    22 CALRAKVC-------GASGQFELEILSMQNVNGELQNGNCCGGVRNPGDRKCTRDECDTYFKVCL 79

  Fly    70 KHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWH 134
            |.||:.:.....|::|...||::|.|:.|| .|.|..::   |.|..||||:||.:::|:||||.
Mouse    80 KEYQSRVTAGGPCSFGSGSTPVIGGNTFNL-KASRGNDR---NRIVLPFSFAWPRSYTLLVEAWD 140

  Fly   135 DTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRP 199
            .:|::....:   :|::.....::..|.:|:|.|..:.....||..|||||.:|||.||.|||||
Mouse   141 SSNDTIQPDS---IIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRP 202

  Fly   200 RDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNECVL 262
            |||.|||..|.:.|...|:.||.|..|:...|.:||  :||.|..|..|.||.||:|..|::|:.
Mouse   203 RDDFFGHYACDQNGNKTCMEGWMGPDCNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIP 267

  Fly   263 EPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDD 327
            .|.|:|||||:||.|:|...|||..|::|||||..|:||.|.|||.|||...|.|.|..||||.:
Mouse   268 HPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPN 332

  Fly   328 CENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNV 391
            ||...::|.:|  ||.|.|:|   ..|.:|::|.|:.||:|..|...:..||...| |.|.|:::
Mouse   333 CEIAEHACLSD--PCHNRGSC---KETSSGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL 392

  Fly   392 RPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQ---PSGKCICPAGFSGTRCETN 453
                   ..|::|.||..::|..|.|..:.|...||:|..||:   .|..|.|..|:.|..|:.|
Mouse   393 -------VNGFKCVCPPQWTGKTCQLDANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCDIN 450

  Fly   454 IDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCR 518
            |:|||| ||:|..:|.|:||.|||.|.||:.|.||...:|.|...||.|||.|.|..|.:||.|.
Mouse   451 INDCLG-QCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCP 514

  Fly   519 AGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDE----------ESYDSVT 573
            .||:|..|.:|||.|...||.||..|.||.:.:.|.|...:.||.|..          |..||.|
Mouse   515 TGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTTCEVIDSCT 579

  Fly   574  573
            Mouse   580  579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DeltaNP_477264.1 MNNL 23..182 CDD:462222 53/159 (33%)
DSL 164..226 CDD:128366 32/61 (52%)
EGF_CA 291..329 CDD:238011 22/37 (59%)
EGF_CA 337..372 CDD:238011 13/34 (38%)
EGF_CA 453..488 CDD:238011 20/34 (59%)
EGF_CA 492..526 CDD:238011 16/33 (48%)
EGF_CA 529..564 CDD:238011 15/34 (44%)
Jag1NP_038850.1 MNNL 32..185 CDD:462222 53/159 (33%)
DSL 167..229 CDD:128366 32/61 (52%)
Important for interaction with NOTCH1. /evidence=ECO:0000250 199..207 7/7 (100%)
EGF_CA 296..334 CDD:238011 22/37 (59%)
EGF 340..370 CDD:394967 14/34 (41%)
EGF_CA 374..410 CDD:238011 11/42 (26%)
EGF_CA 412..447 CDD:238011 11/34 (32%)
EGF_CA 450..485 CDD:238011 21/35 (60%)
EGF_CA 487..523 CDD:238011 16/35 (46%)
EGF_CA 525..560 CDD:238011 15/34 (44%)
EGF_CA 629..665 CDD:238011
EGF_CA 667..702 CDD:238011
EGF_CA <714..740 CDD:238011
EGF 748..777 CDD:394967
EGF_CA 782..817 CDD:238011
EGF_CA 820..855 CDD:238011
VWC_out 863..930 CDD:214565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1218
Blue background indicates that the domain is not in the aligned region.

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