DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dl and jag1b

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_571938.2	Gene:	jag1b / 140423	ZFINID:	ZDB-GENE-011128-4	Length:	1213	Species:	Danio rerio

Alignment Length:	985	Identity:	311/985 - (31%)
Similarity:	417/985 - (42%)	Gaps:	262/985 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTAF-ICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCL-GSCKTRFRVCLK 70
            |.|| :|....|. .:||.|||.:....|.:|....|.||.|..:.|..||. ..|.|.|:||||
Zfish    14 LHAFLLCLRTTVS-DASGHFELEILSMQNANGELQNGACCDGARNPADRKCTRDECDTYFKVCLK 77

  Fly    71 HYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNP---IQFPFSFSWPGTFSLIVEA 132
            .||:.:.:...|::|...||:||.|        :|..||..:.   |..||||:||.:::|||||
Zfish    78 EYQSRVSSAGACSFGTGSTPVLGGN--------KFSTKGTRSEKSRIVLPFSFAWPRSYTLIVEA 134

  Fly   133 WHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFC 197
            . |.||...:.:.| ||::.....::..:.:|:...........||..||||..:|||.||.|||
Zfish   135 L-DFNNETASESGK-LIEKAYHSGMINPNRQWQRLTHNGPVAQFEYQIRVTCLEHYYGFGCNKFC 197

  Fly   198 RPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNEC 260
            ||||:.|||.||.:.|...||.||.|..|:...|.:||  |||.|.:|..|.|..||:|..|::|
Zfish   198 RPRDEFFGHYTCDQNGNKTCLEGWTGPDCNTAICRQGCSTEHGSCKQPGGCKCLYGWQGPYCDKC 262

  Fly   261 VLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSG 325
            :..|.|:||||.:||.|:|:..|||..|::|||||..|:||.|||||.|||...|.|.|..||||
Zfish   263 IPHPGCVHGTCVEPWQCLCDTNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCEDGYSG 327

  Fly   326 DDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICR 389
            .:||...::|.:  |||.|||||   ..|..||:||||.||||..||..|..|:...| |.|.|:
Zfish   328 VNCERAEHACLS--NPCANGGTC---KETSQGYECHCAIGWSGTSCEINVDDCTPNQCKHGGTCQ 387

  Fly   390 NVRPG-----------------------------------LGS---------------------K 398
            ::..|                                   :|:                     |
Zfish   388 DLVNGFKCACPPHWTGKTCQIDANECEDKPCVNAKSCHNLIGAYFCECLPGWSGQNCDININDCK 452

  Fly   399 GQ------------GYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQP--SG-KCICPAGFSGT 448
            ||            ||:|.||.||:|..|:..:|.|:.:||:|||.||.  :| :|:|||||||.
Zfish   453 GQCLNGGTCKDLVNGYRCLCPPGYTGEQCEKDVDECASSPCLNGGRCQDEVNGFQCLCPAGFSGQ 517

  Fly   449 RCETNIDDCLGHQCENGGTCIDMVN---------------------------------------- 473
            .|:.:||.|..:.|:||..|.::.:
Zfish   518 LCQLDIDYCKPNPCQNGAQCFNLASDYFCKCPDDYEGKNCSHLKDHCRTTSCQVIDSCTVAVASN 582

  Fly   474 --------------------------QYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNND 512
                                      |:.|:|..||.||:|...::.|...||.|||||::..|.
Zfish   583 STPEGVRYISSNVCGPHGRCRSQAGGQFTCECQEGFRGTYCHENINDCESNPCRNGGTCIDKVNV 647

  Fly   513 YQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGK-------QCDEESYD 570
            |||.|..|:.|..|.::||:||..||.|.|.|.:.||.|.|.|.||::||       ||||.:.:
Zfish   648 YQCICADGWEGVHCEINIDDCSLNPCLNKGACQDLVNDFYCECRNGWKGKTCHSRDSQCDEATCN 712

  Fly   571 SVTFDAHQYGATTQARADGLTNAQVVLIAVFSVAMPLVAVI-AACVV-------FCMKRKRKRAQ 627
            : ....|..|.|.:.|...........||..|..:|..... ..|||       .|
Zfish   713 N-GGTCHDEGDTFKCRCSPGWEGATCNIAKNSSCLPNPCENGGTCVVNGDSFNCVC--------- 767

  Fly   628 EKDDAEARKQNEQNAVATMHHNGSGVGVALASASLGGKTGSNSGLTFDGGNPNIIKNTW------ 686
                    |:..:.:..|.:.|........           |||...||.|       |
Zfish   768 --------KEGWEGSTCTENTNDCNPHPCY-----------NSGTCVDGEN-------WYRCECA 806

  Fly   687 ------DKSVN-NICASAAAAAAAAAAADE-----CLMYGGYVASVADNNNANSDFCVAPLQ--- 736
                  |..:| |.|.| :..|..:...||     ||...|.:.  .|........|:|..|
Zfish   807 PGFAGPDCRININECQS-SPCAFGSTCVDEINGYRCLCPPGRIG--PDCQEVVGRPCIANGQVTA 868

  Fly   737 -RAKSQKQLN--------TDPTLMHRGSPAGSSAKGASGGGPGAAE----------GKRISVLGE 782
             .||.::..|        ...|:|..|..:..:.| |.||.|.:..          .|....|||
Zfish   869 DGAKWEEDCNICQCQNGRIHCTMMWCGPKSCRTGK-ARGGCPASQSCVPIKEEQCFVKPCPSLGE 932

  Fly   783 GSYCSQRWPS 792
               |   |||
Zfish   933 ---C---WPS 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	29/73 (40%)
		DSL	164..226	CDD:279722	30/61 (49%)
		EGF_CA	291..329	CDD:238011	23/37 (62%)
		EGF_CA	337..372	CDD:238011	19/34 (56%)
		EGF_CA	453..488	CDD:238011	14/100 (14%)
		EGF_CA	492..526	CDD:238011	15/33 (45%)
		EGF_CA	529..564	CDD:238011	18/41 (44%)
jag1b	NP_571938.2	MNNL	29..102	CDD:284966	29/72 (40%)
		DSL	164..226	CDD:279722	30/61 (49%)
		EGF_CA	293..331	CDD:238011	23/37 (62%)
		EGF	337..365	CDD:278437	18/32 (56%)
		EGF_CA	371..407	CDD:238011	7/35 (20%)
		EGF_CA	409..444	CDD:238011	1/34 (3%)
		EGF_CA	447..482	CDD:238011	11/34 (32%)
		EGF_CA	484..520	CDD:238011	18/35 (51%)
		EGF_CA	522..557	CDD:238011	7/34 (21%)
		EGF_CA	626..662	CDD:238011	15/35 (43%)
		EGF_CA	664..699	CDD:238011	18/34 (53%)
		EGF_CA	<711..737	CDD:238011	4/26 (15%)
		EGF	745..775	CDD:278437	6/46 (13%)
		EGF_CA	779..814	CDD:238011	8/52 (15%)
		EGF_CA	817..853	CDD:238011	11/38 (29%)
		VWC_out	860..927	CDD:214565	15/67 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578045
Domainoid	1	1.000	50	1.000	Domainoid score	I11640
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850