Protein Alignment Dl and Dll3

DIOPT Version :9

• Sequence 1: NP_001247193.1
• Gene: Dl / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: NP_031892.2
• Gene: Dll3 / 13389
• MGIID: 1096877
• Length: 585
• Species: Mus musculus
• Alignment Length: 544
• Identity: 168/544 - (30%)
• Similarity: 233/544 - (42%)
• Gaps: 118/544 - (21%)

  Fly     7 LLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKH 71
            |:.||:    :.|...:|.|||::..|....|.......|:..         |.|:..||||||.
Mouse    13 LILAFL----LPQALPAGVFELQIHSFGPGPGLGTPRSPCNAR---------GPCRLFFRVCLKP 64

  Fly    72 YQATIDTTSQCTYGDVIT---PILGEN------SVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFS 127
            ..:...|.|.|..|..::   |:..|:      ::.|.|..          ::.||..:||||||
Mouse    65 GVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLPDGL----------VRVPFRDAWPGTFS 119

  Fly   128 LIVEAWHDT--NNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYG 190
            |::|.|.:.  .::|....|  |:.|::.::.|.....|..:...:....|.:.:|..|:....|
Mouse   120 LVIETWREQLGEHAGGPAWN--LLARVVGRRRLAAGGPWARDVQRTGTWELHFSYRARCEPPAVG 182

  Fly   191 SGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPK-CAKGC--EHGHCDKPNQCVCQLGW 252
            :.||:.||.|.   ..|.|. .|...| |.:. |.|..|. |..||  |||:|::|::|.|..||
Mouse   183 AACARLCRSRS---APSRCG-PGLRPC-TPFP-DECEAPSVCRPGCSPEHGYCEEPDECRCLEGW 241

  Fly   253 KGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHR---PCKNGGTCFNTGEGL 314
            .|.||...|...:|:                             |.|   |...|  |...|.|
Mouse   242 TGPLCTVPVSTSSCL-----------------------------NSRVPGPASTG--CLLPGPG- 274

  Fly   315 YTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCS 379
                               .||.  |||.|||:|.:   |...::|.|..|:.|..||...:||:
Mouse   275 -------------------PCDG--NPCANGGSCSE---TSGSFECACPRGFYGLRCEVSGVTCA 315

  Fly   380 DKPCHQGICRNVRPGLGSKGQ----GYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSG--- 437
            |.||..|       ||...|:    .|.|.||.|:.|.||:.::|.||..||.|||.|...|
Mouse   316 DGPCFNG-------GLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHAL 373

  Fly   438 KCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCAN 502
            :|.|.|||:|.|||.::|||.|..|.|||||::.....||.|..||.|..|..:.|.|..||||:
Mouse   374 RCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAH 438

  Fly   503 GGTCLNLNNDYQCTCRAGFTGKDC 526
            ||.|....:...|.|..|:.|..|
Mouse   439 GGRCYAHFSGLVCACAPGYMGVRC 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	21/81 (26%)
		DSL	164..226	CDD:279722	16/61 (26%)
		EGF_CA	291..329	CDD:238011	7/40 (18%)
		EGF_CA	337..372	CDD:238011	12/34 (35%)
		EGF_CA	453..488	CDD:238011	16/34 (47%)
		EGF_CA	492..526	CDD:238011	13/33 (39%)
		EGF_CA	529..564	CDD:238011
Dll3	NP_031892.2	MNNL	25..85	CDD:284966	19/68 (28%)
		DSL	156..246	CDD:302925	31/95 (33%)
		EGF_CA	277..308	CDD:238011	13/35 (37%)
		EGF_CA	314..349	CDD:238011	15/41 (37%)
		EGF_CA	352..387	CDD:238011	17/34 (50%)
		EGF_CA	389..424	CDD:238011	16/34 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..567

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910