DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and Dll3

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_446118.2	Gene:	Dll3 / 114125	RGDID:	70953	Length:	589	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	165/544 - (30%)
Similarity:	231/544 - (42%)	Gaps:	114/544 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKH 71
            |:.||:    :.|...:|.|||::..|....|.......|:..         |.|:..||||||.
  Rat    13 LILAFL----LPQALPAGVFELQIHSFGPGPGPGTPRSPCNAR---------GPCRLFFRVCLKP 64

  Fly    72 YQATIDTTSQCTYGDVIT---PILGEN------SVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFS 127
            ..:.....|.|..|..::   |:..|.      :::|.|..          ::.||..:||||||
  Rat    65 GVSQEAAESLCALGAALSTSGPVYTEQPGVPAAALSLPDGL----------VRVPFRDAWPGTFS 119

  Fly   128 LIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSG 192
            ||:|.|.:......|.....|:.|:..::.|...:.|..:...:....|.:.:|..|:....|:.
  Rat   120 LIIETWREQLGERAAGPAWNLLARVAGRRRLAAGAPWARDVQRTGAWELHFSYRARCEPPAVGAA 184

  Fly   193 CAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPK-----CAKGC--EHGHCDKPNQCVCQL 250
            ||:.||.|.   ..|.|. .|...| |.:. |.|..|:     |..||  |||:|::|::|.|..
  Rat   185 CARLCRSRS---APSRCG-PGLRPC-TPFP-DECEAPRESLTVCRAGCSPEHGYCEEPDECHCLE 243

  Fly   251 GWKGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGT-CFNTGEGL 314
            ||.|.||...|...:|::...:.|                             .|| |...|.|
  Rat   244 GWTGPLCTVPVSTSSCLNSRVSGP-----------------------------AGTGCLLPGPG- 278

  Fly   315 YTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCS 379
                               .||.  |||.|||:|.:.|.:   ::|.|..|:.|..||...:||:
  Rat   279 -------------------PCDG--NPCANGGSCSETPGS---FECACPRGFYGPRCEVSGVTCA 319

  Fly   380 DKPCHQGICRNVRPGLGSKGQ----GYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSG--- 437
            |.||..|       ||...|:    .|.|.||..:.|.||:.::|.||..||.|||.|...|
  Rat   320 DGPCFNG-------GLCVGGEDPDSAYVCHCPPAFQGSNCERRVDRCSLQPCQNGGLCLDLGHAL 377

  Fly   438 KCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCAN 502
            :|.|.|||:|.|||.::|||.|..|.|||||::.....||.|..||.|..|..:.|.|..||||:
  Rat   378 RCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGARRCSCALGFGGRDCRERADPCASRPCAH 442

  Fly   503 GGTCLNLNNDYQCTCRAGFTGKDC 526
            ||.|....:...|.|..|:.|..|
  Rat   443 GGRCYAHFSGLVCACAPGYMGVRC 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	20/81 (25%)
		DSL	164..226	CDD:279722	16/61 (26%)
		EGF_CA	291..329	CDD:238011	5/38 (13%)
		EGF_CA	337..372	CDD:238011	12/34 (35%)
		EGF_CA	453..488	CDD:238011	16/34 (47%)
		EGF_CA	492..526	CDD:238011	13/33 (39%)
		EGF_CA	529..564	CDD:238011
Dll3	NP_446118.2	MNNL	25..82	CDD:400141	18/65 (28%)
		EGF_CA	281..312	CDD:238011	13/35 (37%)
		EGF_CA	356..391	CDD:238011	17/34 (50%)
		EGF_CA	393..428	CDD:238011	16/34 (47%)
		EGF_CA	433..467	CDD:238011	14/34 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910