DRSC/TRiP Functional Genomics Resources

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Protein Alignment Delta and DLL3

DIOPT Version :10

Sequence 1:NP_477264.1 Gene:Delta / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_058637.1 Gene:DLL3 / 10683 HGNCID:2909 Length:618 Species:Homo sapiens


Alignment Length:649 Identity:181/649 - (27%)
Similarity:250/649 - (38%) Gaps:156/649 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 TAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQ 73
            |..:....:.|...:|.|||::..|....|.......||...         .|:..||||||...
Human    13 TVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARL---------PCRLFFRVCLKPGL 68

  Fly    74 ATIDTTSQCTYGDVIT---PILGEN------SVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLI 129
            :.....|.|..|..::   |:..|.      .:.|.|..          :|.||..:||||||.|
Human    69 SEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGL----------LQVPFRDAWPGTFSFI 123

  Fly   130 VEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCA 194
            :|.|.:............|:.|:..::.|.....|..:...:....|.:.:|..|:....|:.|.
Human   124 IETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACT 188

  Fly   195 KFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIP-KCAKGC--EHGHCDKPNQCVCQLGWKGAL 256
            :.||||      |..|..|..:.......|.|..| .|..||  |||.|::|.:|.|..||.|.|
Human   189 RLCRPR------SAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPL 247

  Fly   257 CNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKC-- 319
            |...|...:|:                                 ...|.:...||       |  
Human   248 CTVPVSTSSCL---------------------------------SPRGPSSATTG-------CLV 272

  Fly   320 -APGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC 383
             .||           .||.  |||.|||:|.:.|.:   ::|.|..|:.|..||...:||:|.||
Human   273 PGPG-----------PCDG--NPCANGGSCSETPRS---FECTCPRGFYGLRCEVSGVTCADGPC 321

  Fly   384 -HQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSG---KCICPAG 444
             :.|:|    .|.......|.|.||.|:.|.||:.::|.||..||.|||.|...|   :|.|.||
Human   322 FNGGLC----VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAG 382

  Fly   445 FSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNL 509
            |:|.|||.::|||.|..|.|||||::....:||.|..||.|..|..:.|.|..||||:||.|.  
Human   383 FAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCY-- 445

  Fly   510 NNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTF 574
                     |.|:|                           ..|.||.|:.|.:|:        |
Human   446 ---------AHFSG---------------------------LVCACAPGYMGARCE--------F 466

  Fly   575 DAHQYGATT-QARADGLT--NAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEAR 635
            ..|..||:. .|...||.  :.|..|:......:....|..|.::....|:|..:|   ||.:|
Human   467 PVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQ---DAGSR 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DeltaNP_477264.1 MNNL 23..182 CDD:462222 39/167 (23%)
DSL 164..226 CDD:128366 14/61 (23%)
EGF_CA 291..329 CDD:238011 6/40 (15%)
EGF_CA 337..372 CDD:238011 12/34 (35%)
EGF_CA 453..488 CDD:238011 16/34 (47%)
EGF_CA 492..526 CDD:238011 12/33 (36%)
EGF_CA 529..564 CDD:238011 5/34 (15%)
DLL3NP_058637.1 MNNL 27..175 CDD:462222 39/166 (23%)
DSL 158..248 CDD:473190 29/95 (31%)
EGF_CA 279..310 CDD:238011 13/35 (37%)
EGF 316..349 CDD:394967 13/36 (36%)
EGF_CA 354..389 CDD:238011 17/34 (50%)
EGF_CA 391..426 CDD:238011 16/34 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 546..566
Blue background indicates that the domain is not in the aligned region.

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