DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dl and Dlk2

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_001272942.1	Gene:	Dlk2 / 106565	MGIID:	2146838	Length:	382	Species:	Mus musculus

Alignment Length:	464	Identity:	121/464 - (26%)
Similarity:	176/464 - (37%)	Gaps:	163/464 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 SGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVCQLGWK 253
            |||              .|.....::|:.|..........|:..|:  ||.|.....|.|..||:
Mouse     3 SGC--------------RCLNLVCLLCILGATSQPARADDCSSHCDLAHGCCAPDGSCRCDPGWE 53

  Fly   254 GALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCK 318
            |..|..||..|.|.||||::||.|||:.||.|.:|::|.:.||:..||:|||.|...|.|.|.|.
Mouse    54 GLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTSQSPCQNGGQCVYDGGGEYHCV 118

  Fly   319 CAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC 383
            |.||:.|..||.:       ..||:..|.
Mouse   119 CLPGFHGRGCERK-------AGPCEQAGF------------------------------------ 140

  Fly   384 HQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGT 448
                                                      ||.|||.||
Mouse   141 ------------------------------------------PCRNGGQCQ-------------- 149

  Fly   449 RCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDY 513
                          :|.|..::    :.|:|:.||.|.||...||.||:||||||.||::..|.:
Mouse   150 --------------DNQGFALN----FTCRCLAGFMGAHCEVNVDDCLMRPCANGATCIDGINRF 196

  Fly   514 QCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCD------------- 565
            .|.|..||.|:.|::::|:|:|.||..|..|.:||:.|:|:|.:|:.||.|:
Mouse   197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPAPEPASVGT 261

  Fly   566 -EESYDSVTFDA-----HQYGA---------TTQARADGLTNAQVVLIAVFSVAMPLVAVIAACV 615
             :....:|...|     |..||         ..:.:..||..:.:|.:.||...  ..|::.|.|
Mouse   262 PQMPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQESGLGESSLVALVVFGSL--TAALVLATV 324

  Fly   616 VFCMKRKRK 624
            :..::..|:
Mouse   325 LLTLRAWRR 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966
		DSL	164..226	CDD:279722	6/34 (18%)
		EGF_CA	291..329	CDD:238011	17/37 (46%)
		EGF_CA	337..372	CDD:238011	3/34 (9%)
		EGF_CA	453..488	CDD:238011	7/34 (21%)
		EGF_CA	492..526	CDD:238011	18/33 (55%)
		EGF_CA	529..564	CDD:238011	15/34 (44%)
Dlk2	NP_001272942.1	EGF_CA	89..129	CDD:238011	17/39 (44%)
		EGF_CA	174..210	CDD:238011	18/35 (51%)
		EGF_CA	212..248	CDD:238011	15/35 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24044
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100