Protein Alignment Delta and NOTCH2NLB

DIOPT Version :10

• Sequence 1: NP_477264.1
• Gene: Delta / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: XP_047276538.1
• Gene: NOTCH2NLB / 100996763
• HGNCID: 53923
• Length: 338
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 95/290 - (32%)
• Similarity: 132/290 - (45%)
• Gaps: 65/290 - (22%)

  Fly   286 LYCNQD---------LNYCTN-HRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVN 340
            |:|:.:         |:.|.: :.||.|.|.|.....|...|||..|:.|:.|::. ..|:.  |
Human    36 LFCSGEQTSNWNAWLLDKCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHR-DPCEK--N 97

  Fly   341 PCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQGICRNVRPGLGSKGQGYQCE 405
            .|||||||:.:...... .|.||:|::|:.|:..    :..||...
Human    98 RCQNGGTCVAQAMLGKA-TCRCASGFTGEDCQYS----TSHPCFVS------------------- 138

  Fly   406 CPIGYSGPNCDLQLDNCSPNPCINGGSC----QPSGKCICPAGFSGTRCETNIDDCLGHQCENGG 466
                               .||:|||:|    :.:.:|.|..||:|..|:.. |.||.|.|.||.
Human   139 -------------------RPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGS 183

  Fly   467 TCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRP--CANGGTCLNLNNDYQCTCRAGFTGKDCSVD 529
            ||..:.||:.|:|:.||.|..|.:.|:.|.| |  |.:||.||||...|||.|..||||:.|...
Human   184 TCTTVANQFSCKCLTGFTGQKCETDVNECDI-PGHCQHGGICLNLPGSYQCQCLQGFTGQYCDSL 247

  Fly   530 IDECSSGPCHNGGTCMNRVN-SFECVCANG 558
            ...|:..||.|||||....: :|||.|..|
Human   248 YVPCAPSPCVNGGTCRQTGDFTFECNCLPG 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Delta	NP_477264.1	MNNL	23..182	CDD:462222
		DSL	164..226	CDD:128366
		EGF_CA	291..329	CDD:238011	13/47 (28%)
		EGF_CA	337..372	CDD:238011	13/34 (38%)
		EGF_CA	453..488	CDD:238011	16/34 (47%)
		EGF_CA	492..526	CDD:238011	19/35 (54%)
		EGF_CA	529..564	CDD:238011	13/31 (42%)
NOTCH2NLB	XP_047276538.1	EGF_CA	135..169	CDD:238011	12/71 (17%)
		EGF_CA	172..206	CDD:238011	16/33 (48%)
		EGF_CA	208..244	CDD:238011	19/36 (53%)