DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dl and jag2

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	XP_012824896.2	Gene:	jag2 / 100497180	XenbaseID:	XB-GENE-485160	Length:	1224	Species:	Xenopus tropicalis

Alignment Length:	673	Identity:	239/673 - (35%)
Similarity:	311/673 - (46%)	Gaps:	134/673 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AFICFTVIVQV-HSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKC-LGSCKTRFRVCLKHY 72
            |.:..|:.||| ||:|.|||:|....|.:|....|.||..........| ...|.|..:||||.:
Frog    15 ALVLLTLWVQVSHSTGYFELQLISLKNANGELLNGECCDDIKSAQNLDCGRDECDTYLKVCLKEF 79

  Fly    73 QATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNP-----IQFPFSFSWPGTFSLIVEA 132
            ||.|..|..|.||...|.:||.|::.|   .::.::|.:||     |..||.|:|..:|:||:||
Frog    80 QAKITPTGPCNYGSGFTSVLGGNTIYL---NKYNHQGKSNPSESGRITIPFQFAWTRSFTLILEA 141

  Fly   133 WHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFC 197
            | |.:|.... ...|||.|:....|.....:|............:...||.||.|||||.|.|||
Frog   142 W-DWDNDTKV-DEDLLIDRVTYAGVTSPEDQWTLLPLTGHVAQFDVKIRVKCDENYYGSMCNKFC 204

  Fly   198 RPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVCQLGWKGALCNEC 260
            |||:|..||.||...|:..|:.||.|..|....|.:||:  ||.|..|.:|.|..||:|..|:||
Frog   205 RPRNDFVGHYTCDSNGKKACMEGWMGAECKQAICKQGCDLLHGGCTVPGECKCHYGWQGLYCSEC 269

  Fly   261 VLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSG 325
            |..|.|:||:|.:||.|.|...||||.||:|||||..|.||.|||||.||....|.|.|..||||
Frog   270 VPYPGCVHGSCQEPWDCKCETNWGGLLCNKDLNYCGTHHPCLNGGTCMNTEPDKYYCACPDGYSG 334

  Fly   326 DDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQ-GICR 389
            .:||...::|.:  |||.|.|.|.:   ..:|::|||..||:|..|...:..|:..||.. |.|:
Frog   335 QNCEIAEHACAS--NPCANDGVCHE---VSSGFECHCPPGWTGTTCAVDIDECASNPCASGGECK 394

  Fly   390 NVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCING------------------------ 430
            ::.       .|::|.||..::|..|.|..:.|...||:|.
Frog   395 DLI-------NGFECICPPQWAGTTCQLDANECEGKPCLNAYACRNLIGRYFCHCLPGWTGLNCH 452

  Fly   431 --------GSCQPSG---------KCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQ 478
                    |.||..|         :||||.||.|..||..::.|....|:|||||.|.||.:||.
Frog   453 IKKSDDCHGQCQNGGICKDKVNGYRCICPRGFVGKNCEIELNKCASKPCQNGGTCEDHVNTFRCH 517

  Fly   479 CVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDY------------------------------ 513
            |.||:.||.|...||||...||.|...|.||:.||
Frog   518 CAPGYSGTLCELTVDLCEPNPCQNKARCYNLDGDYYCACSDDYDGKNCTHLKDHCKNSSCKIIDS 582

  Fly   514 ------------------------------------QCTCRAGFTGKDCSVDIDECSSGPCHNGG 542
                                                .|:|..||||..|..:|::|...||.|||
Frog   583 CTIAISTNATQEGIRYISSNVCGPHGRCISQPGGNFTCSCDRGFTGAYCHENINDCLGTPCKNGG 647

  Fly   543 TCMNRVNSFECVCANGFRGKQCD 565
            ||.:.::||:|.|.||:.|:.||
Frog   648 TCTDEIDSFKCFCPNGWGGEFCD 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	27/73 (37%)
		DSL	164..226	CDD:279722	27/61 (44%)
		EGF_CA	291..329	CDD:238011	22/37 (59%)
		EGF_CA	337..372	CDD:238011	13/34 (38%)
		EGF_CA	453..488	CDD:238011	17/34 (50%)
		EGF_CA	492..526	CDD:238011	18/99 (18%)
		EGF_CA	529..564	CDD:238011	16/34 (47%)
jag2	XP_012824896.2	MNNL	29..103	CDD:400141	27/73 (37%)
		DSL	171..233	CDD:396134	27/61 (44%)
		EGF_CA	300..338	CDD:238011	22/37 (59%)
		EGF	344..372	CDD:394967	13/32 (41%)
		EGF_CA	378..414	CDD:238011	10/42 (24%)
		EGF_CA	416..451	CDD:238011	4/34 (12%)
		EGF_CA	457..490	CDD:238011	11/32 (34%)
		EGF_CA	494..528	CDD:238011	17/33 (52%)
		EGF_CA	531..566	CDD:238011	12/34 (35%)
		EGF_CA	634..669	CDD:238011	16/34 (47%)
		EGF_CA	674..707	CDD:238011
		EGF_CA	715..745	CDD:238011
		EGF_CA	755..785	CDD:238011
		EGF_CA	787..822	CDD:238011
		EGF_CA	825..861	CDD:238011
		VWC_out	870..940	CDD:214565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5948
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920