Protein Alignment Dl and dll4

DIOPT Version :9

• Sequence 1: NP_001247193.1
• Gene: Dl / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: XP_002939596.3
• Gene: dll4 / 100489166
• XenbaseID: XB-GENE-480902
• Length: 673
• Species: Xenopus tropicalis
• Alignment Length: 575
• Identity: 245/575 - (42%)
• Similarity: 330/575 - (57%)
• Gaps: 70/575 - (12%)

  Fly    16 VIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTS 80
            ::.||.|||.|:|.|..|.|.:|....|:           .||.:|:|.|::|||||| |:.:..
 Frog    17 LVKQVSSSGVFQLELHEFINTNGMLVNGK-----------SCLPNCRTFFKICLKHYQ-TVVSPG 69

  Fly    81 QCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTN 145
            .||:|.||||:||.|:.::...:     ||||||:.||:|:||.|||||:||:|...:...   .
 Frog    70 SCTFGSVITPVLGSNTFSIKGME-----GFTNPIKLPFNFTWPKTFSLIIEAFHSPTDLSQ---Q 126

  Fly   146 KLLIQRLLVQQVLEVSSEWKTN-KSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTC 209
            ::.|.:..:|:.|.|..||..: :|......|::.:||.|..||||..|::.|:||||.|||..|
 Frog   127 EIKISQFTIQKPLNVGEEWSRDIQSGGSQIQLKFSYRVVCSENYYGESCSRLCKPRDDRFGHYLC 191

  Fly   210 SETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNECVLEPNCIHGTCN 272
            ...|.:.||.||:|:||..|.|..||  ::|:|:||.:|.|:.||:|..||||:....|.||||.
 Frog   192 EPDGRVSCLKGWKGEYCAEPICLDGCSEQNGYCNKPGECTCRPGWQGRFCNECIPHNGCRHGTCQ 256

  Fly   273 KPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDA 337
            ..|.|||:||||||:|:|||||||:|:|||||.||.|||:|.|||.|.||:||.:||::|..||:
 Frog   257 IQWQCICDEGWGGLFCDQDLNYCTHHKPCKNGATCMNTGQGSYTCSCPPGFSGVNCEDKIRECDS 321

  Fly   338 DVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNVRPGLGSKGQG 401
              |||:|||:|.|   .:.||:|.|..|:.|..||:.||.|.:.|| :.|.||.     ...|..
 Frog   322 --NPCRNGGSCRD---LENGYRCECPQGYDGSHCEKSVLNCGNSPCFNGGTCRE-----REVGAS 376

  Fly   402 YQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGK---CICPAGFSGTRCETNIDDCLGHQCE 463
            |.|:||:|::|.||:.::|.|:.|||:|||.|...||   |.|..||:|..|..|||||..:.|.
 Frog   377 YTCQCPLGFTGSNCEKKVDKCTRNPCLNGGQCFDFGKTQLCRCRPGFTGPTCAINIDDCAKNPCL 441

  Fly   464 NGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSV 528
            |||.|.|.||.|.|.|.||:.|..|:.|...|:: ||.|||||.....|..|.|..||.|..|..
 Frog   442 NGGICTDAVNDYYCDCPPGYRGRTCNVKTIECIL-PCMNGGTCYIGPYDNNCDCPPGFMGSLCEN 505

  Fly   529 DIDE----------------------C---------SSGPCHNGGTCMNRVNSFE 552
            .|:.                      |         ...|.|...| ||.::.|:
 Frog   506 PIEPKVDFPWVAVFMGAGFVGVLVLLCMVIITFRHFRKQPLHESNT-MNNLSDFQ 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	30/72 (42%)
		DSL	164..226	CDD:279722	26/62 (42%)
		EGF_CA	291..329	CDD:238011	26/37 (70%)
		EGF_CA	337..372	CDD:238011	14/34 (41%)
		EGF_CA	453..488	CDD:238011	19/34 (56%)
		EGF_CA	492..526	CDD:238011	14/33 (42%)
		EGF_CA	529..564	CDD:238011	8/55 (15%)
dll4	XP_002939596.3	MNNL	24..86	CDD:400141	31/73 (42%)
		DSL	145..208	CDD:396134	26/62 (42%)
		EGF_CA	275..313	CDD:238011	26/37 (70%)
		EGF_CA	316..351	CDD:238011	17/39 (44%)
		EGF_CA	359..391	CDD:238011	13/36 (36%)
		EGF	397..427	CDD:394967	15/29 (52%)
		EGF_CA	431..466	CDD:238011	19/34 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	581	1.000	Inparanoid score	I1005
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0002026
OrthoInspector	1	1.000	-	-		otm48695
Panther	1	1.100	-	-	LDO	PTHR24044
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160