Protein Alignment Delta and notch2

DIOPT Version :10

• Sequence 1: NP_477264.1
• Gene: Delta / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: XP_002939126.3
• Gene: notch2 / 100486344
• XenbaseID: XB-GENE-6046917
• Length: 2455
• Species: Xenopus tropicalis
• Alignment Length: 480
• Identity: 162/480 - (33%)
• Similarity: 222/480 - (46%)
• Gaps: 109/480 - (22%)

  Fly   184 CDLNYYGSGCAKFCRPRDDSFGHSTCSETGEII---------CLTGWQGDYC--HIPKCAKG-CE 236
            |:..|.|:    .|..:.|....:.|...|..:         ||.|..|..|  ::..||.. |.
 Frog   591 CEPGYMGA----ICSDQIDECLSNPCLNEGRCVDLVNGYQCNCLPGTSGPRCEKNVDDCASNPCT 651

  Fly   237 HGHC-DKPNQ--CVCQLGWKGALCNE---------------CVLEPN------------------ 265
            :|:| |..|:  |||..|:.|..|.:               ||.|.|
 Frog   652 YGNCVDGINRYDCVCSPGFTGPQCKDDIDECASNPCHNGGTCVNEQNRFRCICPEGFRQPSCFSQ 716

  Fly   266 --------CIHGTCN---KPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKC 319
                    ||||.|.   ..:.|:|..||.|..|..|.|.|.:: ||:|||||.|...| |.|.|
 Frog   717 VDECVNNPCIHGNCTDDVNGYKCLCQPGWTGKKCEVDKNECLSN-PCQNGGTCDNLVNG-YRCSC 779

  Fly   320 APGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCH 384
            ..|:.|.:|:.:|..|.:  |||.|.|||.|..:   ||.|||...::|..|:..:..||.:|||
 Frog   780 KKGFKGYNCQIDIDECAS--NPCLNHGTCRDGIN---GYTCHCGLPYTGTNCQNILTPCSPEPCH 839

  Fly   385 QG-----------------------------------ICRNVRPGLGSKGQGYQCECPIGYSGPN 414
            .|                                   .|:|......:|| ||.|.|..|::|.|
 Frog   840 NGGICQESEDFKSFSCLCATGWHGQRCTIDIDECITNPCKNYGRCQNTKG-GYICHCFEGFNGVN 903

  Fly   415 CDLQLDNCSPNPCINGGSCQP---SGKCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYR 476
            |:..:|:|..|||.||.||..   :..|.|.|||.|.:|:.::|:|..:.|:|||:|.|.||.|.
 Frog   904 CENNIDDCLSNPCQNGASCVDGINTFSCNCLAGFHGDKCQKDVDECASNPCKNGGSCTDYVNSYT 968

  Fly   477 CQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNG 541
            |:|.|||.|.||.:.:|.|....|.||.||::..|.:.|.|..||||:.|..:|:||.|.||.||
 Frog   969 CKCQPGFDGIHCDNNIDECTDTSCFNGATCVDGINSFTCQCPQGFTGQFCLFEINECGSHPCING 1033

  Fly   542 GTCMNRVNSFECVCANGFRGKQCDE 566
            |||::.:.::.|.|..|:|||.|:|
 Frog  1034 GTCVDGMGTYHCTCPVGYRGKNCEE 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Delta	NP_477264.1	MNNL	23..182	CDD:462222
		DSL	164..226	CDD:128366	11/50 (22%)
		EGF_CA	291..329	CDD:238011	17/37 (46%)
		EGF_CA	337..372	CDD:238011	14/34 (41%)
		EGF_CA	453..488	CDD:238011	17/34 (50%)
		EGF_CA	492..526	CDD:238011	14/33 (42%)
		EGF_CA	529..564	CDD:238011	17/34 (50%)
notch2	XP_002939126.3	EGF_CA	141..176	CDD:238011
		EGF_CA	178..215	CDD:238011
		EGF_CA	256..292	CDD:238011
		EGF_CA	294..331	CDD:238011
		EGF_CA	334..369	CDD:238011
		EGF_CA	411..450	CDD:238011
		EGF_CA	452..488	CDD:238011
		EGF_CA	491..526	CDD:238011
		EGF_CA	528..564	CDD:238011
		EGF_CA	566..600	CDD:238011	3/12 (25%)
		EGF_CA	604..639	CDD:238011	7/34 (21%)
		EGF_CA	641..676	CDD:238011	12/34 (35%)
		EGF_CA	678..713	CDD:238011	4/34 (12%)
		EGF_CA	717..751	CDD:238011	10/33 (30%)
		EGF_CA	753..789	CDD:238011	17/37 (46%)
		EGF_CA	791..827	CDD:238011	16/40 (40%)
		EGF_CA	869..905	CDD:238011	11/36 (31%)
		EGF_CA	907..943	CDD:238011	15/35 (43%)
		EGF_CA	945..980	CDD:238011	17/34 (50%)
		EGF_CA	983..1018	CDD:238011	14/34 (41%)
		EGF_CA	1022..1057	CDD:238011	17/34 (50%)
		EGF_CA	1147..1181	CDD:238011
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	1221..1261	CDD:238011
		EGF_CA	1263..1301	CDD:238011
		EGF_CA	<1311..1342	CDD:238011
		Notch	1426..1457	CDD:459658
		Notch	1464..1498	CDD:459658
		Notch	1504..1536	CDD:459658
		NOD	1540..1595	CDD:462014
		NODP	1620..1676	CDD:462229
		JMTM_Notch2	1661..1742	CDD:411986
		ANK repeat	1829..1876	CDD:293786
		ANKYR	<1858..2069	CDD:440430
		ANK repeat	1879..1909	CDD:293786
		ANK repeat	1911..1976	CDD:293786
		ANK repeat	1978..2009	CDD:293786
		ANK repeat	2011..2042	CDD:293786