DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Delta and dll1

DIOPT Version :10

Sequence 1:NP_477264.1 Gene:Delta / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster
Sequence 2:NP_001093689.1 Gene:dll1 / 100101697 XenbaseID:XB-GENE-479210 Length:721 Species:Xenopus tropicalis


Alignment Length:650 Identity:282/650 - (43%)
Similarity:370/650 - (56%) Gaps:77/650 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KCLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCL 69
            :|:||..:.|.|:.|:..||.|||||:.|.|..|......||...|.|...:|  .|||.||:||
 Frog     4 QCMLTLLVLFAVLCQISCSGLFELRLQEFLNKKGLLGNMNCCRPGSLGTLQRC--DCKTFFRICL 66

  Fly    70 KHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWH 134
            ||||:.:.....||||..:||:||.||..:.::.. .:..|:|||:|||.|:||||||||:||.|
 Frog    67 KHYQSNVSPEPPCTYGSAVTPVLGTNSFVVPESSS-SDPTFSNPIRFPFGFTWPGTFSLIIEAIH 130

  Fly   135 -DTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCR 198
             |:.:..|....:.||.||..|:.|.|..:|..:...|..|.|:|.:|..||.:|||.||:.:||
 Frog   131 ADSADDLNTENPERLISRLATQRHLTVGEQWSQDLHSSDRTELKYSYRFVCDEHYYGEGCSDYCR 195

  Fly   199 PRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVCQLGWKGALCNECV 261
            ||||:|||.:|.|.||.:|..||:|.||..|.|..||:  ||:||||.:|.|::||:|..|:||:
 Frog   196 PRDDAFGHFSCGEKGEKLCNPGWKGLYCTEPICLPGCDEHHGYCDKPGECKCRVGWQGRYCDECI 260

  Fly   262 LEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGD 326
            ..|.|:||||.:||.|.|.||||||:|||||||||:|:|||||.||.|||:|.|||.|.|||:|.
 Frog   261 RYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGS 325

  Fly   327 DCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRN 390
            :||.||..|||  |||:|||:|.|   .:..|.|.|..|:.||.||...:||:|.|| :.|.|.:
 Frog   326 NCEIEINECDA--NPCKNGGSCTD---LENSYSCSCPPGFYGKNCELSAMTCADGPCFNGGRCSD 385

  Fly   391 VRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGK---CICPAGFSGTRCET 452
            ...|      ||.|.||:||||.||:.::|.||.|||.||..|:..|.   |.|..||||..|:.
 Frog   386 NPDG------GYICFCPVGYSGFNCEKKIDYCSSNPCANGAHCEDLGNSYICQCQEGFSGRNCDD 444

  Fly   453 NIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTC 517
            |:|||....|:|||||.|.:                                      |||.|||
 Frog   445 NLDDCASFPCQNGGTCQDGI--------------------------------------NDYTCTC 471

  Fly   518 RAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCD----EESYDSVTFDAHQ 578
            ..|:.||:||:.|.:|...|||||.||..|.|.:.|.||.|:.|..|.    ||....|.|    
 Frog   472 PPGYIGKNCSMPITKCEHNPCHNGATCHERNNRYVCQCARGYGGNNCQFLLPEEKTVVVDF---- 532

  Fly   579 YGATTQARADGLTNAQVVLIAVFSVAMPLVAVIAAC--VVFCMK---RKRKRAQEKDDAEARKQN 638
                |:...:| .:.|...|||.:..:.::.::..|  ||.|::   :||:...|....|.:..|
 Frog   533 ----TEKYTEG-QSGQFPWIAVCAGIVLVLMLLLGCAAVVVCVRVRVQKRRHQPEACRGETKTMN 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DeltaNP_477264.1 MNNL 23..182 CDD:462222 69/159 (43%)
DSL 164..226 CDD:128366 30/61 (49%)
EGF_CA 291..329 CDD:238011 26/37 (70%)
EGF_CA 337..372 CDD:238011 15/34 (44%)
EGF_CA 453..488 CDD:238011 11/34 (32%)
EGF_CA 492..526 CDD:238011 9/33 (27%)
EGF_CA 529..564 CDD:238011 16/34 (47%)
dll1NP_001093689.1 MNNL 22..179 CDD:462222 69/159 (43%)
DSL 161..223 CDD:128366 30/61 (49%)
EGF_CA 290..328 CDD:238011 26/37 (70%)
EGF_CA 331..366 CDD:238011 18/39 (46%)
EGF 372..401 CDD:394967 14/34 (41%)
EGF_CA 408..442 CDD:238011 16/33 (48%)
EGF_CA 445..480 CDD:238011 20/72 (28%)
EGF_CA 488..519 CDD:238011 14/30 (47%)

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