Protein Alignment Delta and notch1

DIOPT Version :10

• Sequence 1: NP_477264.1
• Gene: Delta / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: NP_001090757.1
• Gene: notch1 / 100037842
• XenbaseID: XB-GENE-479318
• Length: 2522
• Species: Xenopus tropicalis
• Alignment Length: 703
• Identity: 199/703 - (28%)
• Similarity: 287/703 - (40%)
• Gaps: 202/703 - (28%)

  Fly    21 HSSGSFELRLKYFSND--HGRD---------------NEGRCCSGESDGATGKCLGSCKTRFR-- 66
            ||..:...|:..|..:  |||.               |||..|  :::...||.:.:|...:.
 Frog   344 HSGATCHDRVASFFCECPHGRTGLLCHLDNACISNPCNEGSNC--DTNPVNGKAICTCPPGYTGP 406

  Fly    67 VCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVE 131
            .|...........:.|.:|...|..||....|..       :|:..|                 .
 Frog   407 ACNNDVDECSLGANPCEHGGRCTNTLGSFQCNCP-------QGYAGP-----------------R 447

  Fly   132 AWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEY--DFRVTCDLNYYGSGCA 194
            ...|.|                         |..:|..::..|.|:.  :|:..|...|.|
 Frog   448 CEIDVN-------------------------ECLSNPCQNDATCLDQIGEFQCICMPGYEG---- 483

  Fly   195 KFCRPRDDSFGHSTCSETGEII---------CLTGWQGDYC--HIPKCAK-GCEHG-HC-DKPNQ 245
            .:|....|....:.|...|:.:         |.||:.|:.|  |:.:||. .|::| .| |.||.
 Frog   484 LYCETNIDECASNPCLHNGKCVDKINEFHCECPTGFNGNLCQHHVDECASTPCKNGAKCLDGPNS 548

  Fly   246 --CVCQLGWKGALC----NECVLEPNCIHGTCN---KPWTCICNEGWGGLYCNQDLNYCTNHRPC 301
              |.|..|:.|..|    |||:.:| |.:|||.   ..:||:|..|:.|..|:.|:|.|.: :||
 Frog   549 YTCQCTEGFTGRHCEQDINECIPDP-CHYGTCKDGIATFTCLCRPGYTGRLCDNDINECLS-QPC 611

  Fly   302 KNGGTCFNTGEGL------------------------------------YTCKCAPGYSGDDCEN 330
            :|||.|.:...|.                                    |.|.|.|||:|..|..
 Frog   612 QNGGQCTDRENGYICTCPKGTTGVNCETNLDDCASNPCDYGKCIDKIDGYECTCEPGYTGKMCNI 676

  Fly   331 EIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQGICRNVRPGL 395
            .|..|.:  |||:|||||.|:.:   |:.|.|.:|:...||..:|..|:..||..|.|.:   |:
 Frog   677 NIDECAS--NPCRNGGTCKDKIN---GFTCVCPDGYHDHMCLSEVNECNSNPCIHGTCHD---GI 733

  Fly   396 GSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQP-SGK--CICPAGFSGTRCETNIDDC 457
                .||:|:|..|:||.|||:..:.|..|||:|||:|:. :|.  |.|.|||||..|:|||::|
 Frog   734 ----NGYKCDCDAGWSGSNCDVNNNECESNPCMNGGTCKDMTGAYICTCRAGFSGPNCQTNINEC 794

  Fly   458 LGHQCENGGTCIDMVNQYRCQCV----------------------------------------PG 482
            ..:.|.|.|||||.|..|:|.|:                                        ||
 Frog   795 ASNPCLNRGTCIDDVAGYKCNCMLPYTGAICEAVLAPCSGSPCKNGGRCKESEDYETFSCECPPG 859

  Fly   483 FHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNR 547
            :.|..|...::.|:.|||.||..|.|.|..|:|.|:.|:.|:.|..|||:|...||||||:|.:.
 Frog   860 WQGQTCEIDMNECVNRPCRNGAMCQNTNGSYKCNCKPGYAGRHCETDIDDCQPNPCHNGGSCSDG 924

  Fly   548 VNSFECVCANGFRGKQCDEESYD----------SVTFDAHQYGATTQARADGL 590
            :|.|.|.|..||||.:|:|:..:          :.|...:.|..|.|....|:
 Frog   925 INMFFCNCPAGFRGPKCEEDINECASNPCKNGANCTDCVNSYTCTCQPGFSGI 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Delta	NP_477264.1	MNNL	23..182	CDD:462222	28/179 (16%)
		DSL	164..226	CDD:128366	15/72 (21%)
		EGF_CA	291..329	CDD:238011	17/73 (23%)
		EGF_CA	337..372	CDD:238011	14/34 (41%)
		EGF_CA	453..488	CDD:238011	17/74 (23%)
		EGF_CA	492..526	CDD:238011	14/33 (42%)
		EGF_CA	529..564	CDD:238011	19/34 (56%)
notch1	NP_001090757.1	EGF_CA	108..140	CDD:238011
		EGF	145..175	CDD:394967
		EGF_CA	179..215	CDD:238011
		EGF_CA	223..254	CDD:238011
		EGF_CA	256..292	CDD:238011
		EGF_CA	294..331	CDD:238011
		EGF_CA	334..369	CDD:238011	7/24 (29%)
		EGF_CA	411..449	CDD:238011	8/61 (13%)
		EGF_CA	451..487	CDD:238011	10/64 (16%)
		EGF_CA	489..525	CDD:238011	7/35 (20%)
		EGF_CA	528..563	CDD:238011	12/34 (35%)
		EGF_CA	565..599	CDD:238011	13/34 (38%)
		EGF_CA	602..638	CDD:238011	10/36 (28%)
		EGF_CA	640..674	CDD:238011	7/33 (21%)
		EGF_CA	677..712	CDD:238011	15/39 (38%)
		EGF_CA	716..749	CDD:238011	14/39 (36%)
		EGF_CA	754..788	CDD:238011	16/33 (48%)
		EGF_CA	790..826	CDD:238011	14/35 (40%)
		EGF_CA	833..866	CDD:238011	3/32 (9%)
		EGF_CA	868..904	CDD:238011	14/35 (40%)
		EGF_CA	906..942	CDD:238011	19/35 (54%)
		EGF_CA	944..980	CDD:238011	5/34 (15%)
		EGF_CA	987..1018	CDD:238011
		EGF_CA	1020..1056	CDD:238011
		EGF_CA	1063..1093	CDD:238011
		EGF_CA	<1113..1142	CDD:238011
		EGF_CA	1145..1179	CDD:238011
		EGF_CA	1183..1218	CDD:238011
		EGF_CA	<1237..1264	CDD:238011
		EGF_CA	1266..1303	CDD:238011
		EGF_CA	<1314..1345	CDD:238011
		NL	1440..1477	CDD:197463
		LNR 1	1447..1487
		Notch	1485..1520	CDD:459658
		LNR 2	1488..1529
		LNR 3	1530..1564
		Notch	1532..1560	CDD:459658
		NOD	1563..1618	CDD:462014
		NODP	1665..1728	CDD:462229
		JMTM_Notch1	1714..1794	CDD:411985
		ANK repeat	1877..1923	CDD:293786
		ANK 1	1877..1920
		ANKYR	1915..2125	CDD:440430
		ANK repeat	1925..1956	CDD:293786
		ANK 2	1925..1954
		ANK repeat	1958..1990	CDD:293786
		ANK 3	1958..1988
		ANK repeat	1992..2023	CDD:293786
		ANK 4	1992..2021
		ANK repeat	2025..2089	CDD:293786
		ANK 5	2025..2054
		ANK 6	2058..2087
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2146..2229
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2365..2404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2449..2522