DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc79 and UNC79

DIOPT Version :10

Sequence 1:NP_650795.2 Gene:unc79 / 42310 FlyBaseID:FBgn0038693 Length:3028 Species:Drosophila melanogaster
Sequence 2:XP_011535320.1 Gene:UNC79 / 57578 HGNCID:19966 Length:2752 Species:Homo sapiens


Alignment Length:3283 Identity:961/3283 - (29%)
Similarity:1459/3283 - (44%) Gaps:817/3283 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 TGSF-----KVQLINMGTRAAAFQAKLRALHEYHVRLLHNVLPAPSGVDIANNIKYFSQTLLTVL 61
            ||||     ||:............:|:|.|.|||.|:|||:.|.|||.||||.:||||||||::|
Human    31 TGSFTTARSKVRSGMWTMLVTPVASKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSIL 95

  Fly    62 KD--------------------------------------------------VRTSPHELIRDPL 76
            ..                                                  :|.:|.|  |.|.
Human    96 SRTGKKENQDASNLTVPMTMCLFPVPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSE--RGPQ 158

  Fly    77 EDPTRMSAYPNLEYGNLYNALTMLIDVAPCIQYGQIVFGKALLQCLSCILPFLDKDLIDNLPYLV 141
            ....::|.||:|:|..||..|..|:|:.|.:|:||...|:::....:|:||||:.|::..|||.:
Human   159 SRDAQLSDYPSLDYQGLYVTLVTLLDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDILSTLPYTM 223

  Fly   142 SSTISVLPPALHQCIINALCYYILPFTITRRSSDE-QECQACQSVSSVIMMVLQYSNNPAHHCQL 205
            .||::..||.||:.||..|....||..|...|..| .......|.||::|:.:||::||.:||||
Human   224 ISTLATFPPFLHKDIIEYLSTSFLPMAILGSSRREGVPAHVNLSASSMLMIAMQYTSNPVYHCQL 288

  Fly   206 LECLMTLKHNVVKDILCVVAYGTAVSRTSAAKLLFYYWPAFN--ANLFDRKVLLSKLTNDLVPFT 268
            |||||..|..|.||:|.|:|||.:..:..|.::||:|||...  ..:.:.:.|.....|   |..
Human   289 LECLMKYKQEVWKDLLYVIAYGPSQVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWN---PIH 350

  Fly   269 CQREHCPNSGNAEAAKVCYDHSISIAYAPDCPPPLYLCIECANEIHREHGSLEFGDILHPMQQVS 333
            ||...|.|:.|..|.|:|.|.|:|:|.. |.|||||||.||:..|..:|..... |:|.|..::|
Human   351 CQHIECHNAINKPAVKMCIDPSLSVALG-DKPPPLYLCEECSERIAGDHSEWLI-DVLLPQAEIS 413

  Fly   334 MVCENKNCRSNEKSAFSICFSTECASFNGNHPIRYCSQCHSNRHNSRRGG---DHVVHRSLQP-- 393
            .:|:.|||.|:.:.|...|||..|...:||.|:|||.:||||.|::..|.   .|:...|..|  
Human   414 AICQKKNCSSHVRRAVVTCFSAGCCGRHGNRPVRYCKRCHSNHHSNEVGAAAETHLYQTSPPPIN 478

  Fly   394 AWQMDPEMQMHMVESVVSLLREAKPLNFEPGKESSSSESKKNGSGITADNISLE----------- 447
            ..:...|..:..||:|:|||:||:   |. .::.....:::...|:::.:.||:           
Human   479 TRECGAEELVCAVEAVISLLKEAE---FH-AEQREHELNRRRQLGLSSSHHSLDNADFDNKDDDK 539

  Fly   448 -ERQRLGRYGIWLLVGRCTPTADTPVEVLGRILSMLFHWFHVTAYSYDAAGQVESTIEKLKVDHV 511
             :::.|.::|||.||..|||:.:||.|.|.|:::|:|.|||.|||..|  .:|.|.:||||...|
Human   540 HDQRLLSQFGIWFLVSLCTPSENTPTESLARLVAMVFQWFHSTAYMMD--DEVGSLVEKLKPQFV 602

  Fly   512 CNWLKDICRIHYNVFISCLLPHPPEYARVGGHWETLASRTSHLKEGLQRLICLVPYEVITSEIWD 576
            ..|||.:|.:.::|.:.||||.|.|:|||||:|:...|..:.|||||.|::||:||.||...:|:
Human   603 TKWLKTVCDVRFDVMVMCLLPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVINQSVWE 667

  Fly   577 YVMPHWMEAITNDVAEKELNELKIVLSKILDPEMSPLGFDAKTMYNFVAIRFEKTTAKVQQQALH 641
            .:||.|:|||..:|.:.:|.|.:.||||:.|.|:.||.|..:.|:.|::.||....:.||:|||.
Human   668 CIMPEWLEAIRTEVPDNQLKEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSSVQEQALL 732

  Fly   642 WLQILTKLEILIPLVQLFAMFGDGVRIMKYGIQHELMREKDAQSQSLA-----KAPKTPCKESKE 701
            ||.:|::|:|::||..|.:||.|||..:|     ||..::.::...||     :.........:.
Human   733 WLHVLSELDIMVPLQLLISMFSDGVNSVK-----ELANQRKSRVSELAGNLASRRVSVASDPGRR 792

  Fly   702 TKADMANP-------PRRSSI-SPVVEDDSGNTSAISDDEAPTNRHTEFS-TDAEHNLTCCILML 757
            .:.:|.:|       |.||.: ||.       .|...:...|..|..:|. .|.|.||.|.|||.
Human   793 VQHNMLSPFHSPFQSPFRSPLRSPF-------RSPFKNFGHPGGRTIDFDCEDDEMNLNCFILMF 850

  Fly   758 DILLKQMELQDVEQHMGIHTSVCENVSRLIKCMVTAARVGLSSHVCAL--KVAECAYCEASIMWH 820
            |:|||||||||....||:..|:.:::..:|..:..|...|  ||.|..  |..||..|::||:.:
Human   851 DLLLKQMELQDDGITMGLEHSLSKDIISIINNVFQAPWGG--SHTCQKDEKAIECNLCQSSILCY 913

  Fly   821 QLATKLVQFMAPLNPVRPPDVPIEDIIEEEKSSRKSPPESDKEKTRDRDVSLSMAPLPIPLGPLG 885
            |||.:|::.:||                 ::.||...|....|     |..||..|..| :||.|
Human   914 QLACELLERLAP-----------------KEESRLVEPTDSLE-----DSLLSSRPEFI-IGPEG 955

  Fly   886 GFADIFKLDQFFSDDGKIIIMAGPVPVAVPQPEPHSVGGVLVHMPHVCSNNENGHSVDSNELRKV 950
                                                            ...||            
Human   956 ------------------------------------------------EEEEN------------ 960

  Fly   951 HATDEIMTATVETVSEQLDLASILPTDRAIARSITLSDADVGSANVSVTKASVMGENGANGGGAC 1015
                                                             .||..|||..|    |
Human   961 -------------------------------------------------PASKHGENPGN----C 972

  Fly  1016 GGGENGSGSEEDEEEEDSDDFWHTSVGKFKFTLDTLPQPLQYIHQLLTEIPTIKKPEILYYVLQC 1080
            ......:..:.|.|.              ||....||..|:.|:.:..|:...::|:||:.:|.|
Human   973 TEPVEHAAVKNDTER--------------KFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNC 1023

  Fly  1081 LNTMALHGDALAKAAREQRGFFIWCQENLLIKNLWELCNAEHSHICQVGVPLLLHCITLPLGSDV 1145
            |..:.|||:.|..|.::...|..:.|:::||.:||.:..:|.|.:..:.||||||.::||.|:|:
Human  1024 LKILCLHGECLYIARKDHPQFLAYIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADI 1088

  Fly  1146 FWRVVQEAFHDTDWRVRFTAVERVTVITRFMDSTPLRSEVGLQTALATAFCHLIASMDDINVYVA 1210
            ||.::...|:..||::||.|||:|.||.||:|...:.....|:.:||.|||..:.:::|:|..||
Human  1089 FWTIINGNFNSKDWKMRFEAVEKVAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVA 1153

  Fly  1211 QRATLYIGTIHDTAIRSLLFCLESQFDLFIVDRPVVLQSVYQLHNSLSDRKMLGWEFFLNRFDTL 1275
            .||.|.:.||...|::.|..||:.|||..:.|||.:|..:..||....|...|.||||:|||:||
Human  1154 TRAGLLLDTIKRPALQGLCLCLDFQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETL 1218

  Fly  1276 FVEAQINLEKCG-------DISYLRDLRNSDNGSEALSAKIQKAREALSQSDTSGGMAKTLSASF 1333
            .:|||::|: |.       .|:.:|  .|..|.|:|...||::||.|.::..:    .::|..|.
Human  1219 SLEAQLHLD-CNKEFPFPTTITAVR--TNVANLSDAALWKIKRARFARNRQKS----VRSLRDSV 1276

  Fly  1334 GTKWPYKRTMSAPASMAPRQDSKFVPEKEKIYSRQVSAPILKRKTSRFGLGQFLGSSSGGASGSS 1398
            ......||.:|.|.::..:     :|  .::...:.|||.|                 ||     
Human  1277 KGPVESKRALSLPETLTSK-----IP--MRLTRHEQSAPAL-----------------GG----- 1312

  Fly  1399 QSVNPATTAASSSRPKPPPCPVHQSAHTAFPYHTHHHHPHGHHPYPHPHPHHHPHHHAGSSAHVA 1463
                                                                             
Human  1313 ----------------------------------------------------------------- 1312

  Fly  1464 TTATTSAGLVSTHSQSHQYLVHCVPPSHHSPMPTLQEAETLLRSQAAADAAAASGSFGGSLGHPG 1528
                                         :|..|                             ||
Human  1313 -----------------------------TPEQT-----------------------------PG 1319

  Fly  1529 QEAAAVGTGTAGGSAGNPNPHHSFHSHFQKHPSAPNLLPPPPAPSPSPSTLAFPMHCTCDAAPHP 1593
            |:                                            ||.                
Human  1320 QQ--------------------------------------------SPE---------------- 1324

  Fly  1594 HPQVSGAAATGSAANPDGHIHSLGGLNDDNLIGLLSRITELEESDRETIHLLVFMLMQFMSRTDQ 1658
                                      ||:.:..||.....:   |.:|:|.|:.:||:||:: |:
Human  1325 --------------------------NDNTIKDLLPEDAGI---DHQTVHQLITVLMKFMAK-DE 1359

  Fly  1659 AYPSEEKPMTKTQNIVLKHLFLLLGHNQIDKTFHTTPESLRVSAVFNAFLANLPQVLDQNHLIGG 1723
            :....:....|..|.|.:||::|||::|.:..|...|:.:|:|..||||:|.:.||:|.|..:|.
Human  1360 SSAESDISSAKAFNTVKRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGK 1424

  Fly  1724 LILPSVMQIILYAPNPTSTSGESYQNIVFNYSLWHLEQYPRRNWLFTLLVVLYKYSYTQPPLSGY 1788
            .:||.|:|::.|...|..   ..|.......|||.|:.:.|:.||..|||:||||.|....:|..
Human  1425 HLLPLVVQVLKYCSCPQL---RHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDISKI 1486

  Fly  1789 VIAGIRLIMNSLRGHFHQCRRIPTTTILDIQGVGGAARSRDVSQPSLGTDPDDKEAS-------- 1845
            ::..|.:.:|:|...:|.|:  |..|       .|...| |.|..|..::.:.:|.|        
Human  1487 LLHLIHITVNTLNAQYHSCK--PHAT-------AGPLYS-DNSNISRYSEKEKEEDSVFDESDIH 1541

  Fly  1846 -PPASPMFPSEGTSAASKSKGNVAFTPKLQH----AFRKYNDSSLDADETESELVAIPESD-LSD 1904
             .|..|.           :|.:..|..:|:.    ...||....::...:|.||....|:. |.|
Human  1542 DTPTGPC-----------NKESQTFFARLKRIGGSKMVKYQPVEMNVQRSEIELAEYRETGALQD 1595

  Fly  1905 STLH---GSSAP---------GSFD----DTIHFEDVMPRNRRALEYTEEKSTKSHKSMITTKVG 1953
            |.||   ..|.|         .|.|    |::.|.....|.:..::..:.:...:..:.|..:..
Human  1596 SLLHCVREESIPKKKLRSFKQKSLDIGNADSLLFTLDEHRRKSCIDRCDIEKPPTQAAYIAQRPN 1660

  Fly  1954 DTYTTKIKATTTSETLVTTHTRHSLQEG---VRMIVTPLVG---AETTETAIVSP----PVDVHR 2008
            |...::..:.|..:.  :....:...||   .|..|.|.|.   .||.|..:.||    |.:...
Human  1661 DPGRSRQNSATRPDN--SEIPENPAMEGFPDARRPVIPEVRLNCMETFEVKVDSPVKPAPKEDLD 1723

  Fly  2009 AVTVRNKSL----ENAAASTSKMFAAIATNHLKALGALQDMPAAVERKAASSSGSGSRSANGSGN 2069
            .:.:.:.|.    :::..|||...:.:    .:.|..|:.:.:..|.:..:....|....|.:.:
Human  1724 LIDLSSDSTSGPEKHSILSTSDSDSLV----FEPLPPLRIVESDEEEETMNQGDDGPSGKNAASS 1784

  Fly  2070 GSGGSAPAAIQAS------------SSAAASKPIGRHKTIVECSAGNSSS---SADDSRQKKSQT 2119
            .|..|.|:.:..|            |...:||..|.::     ||||:.|   :.:|....:..:
Human  1785 PSVPSHPSVLSLSTAPLVQVSVEDCSKDFSSKDSGNNQ-----SAGNTDSALITLEDPMDAEGSS 1844

  Fly  2120 KSLRRTDKNYGSP------------DSPLSKMSV--MPNPRDEMDESMQSLPPPKSIAAL----- 2165
            |.....:.:.|||            ...|.:||:  .|:|..|.::..:.:|...:...|     
Human  1845 KPEELPEFSCGSPLTLKQKRDLLQKSFALPEMSLDDHPDPGTEGEKPGELMPSSGAKTVLLKVPE 1909

  Fly  2166 --EIPT----PERLLPIGTQDTVATLVERVRDGLNLPD----------------ISHLKQDSLDV 2208
              |.||    |:......|:......||  .||....:                :|.::::.||:
Human  1910 DAENPTESEKPDTSAESDTEQNPERKVE--EDGAEESEFKIQIVPRQRKQRKIAVSAIQREYLDI 1972

  Fly  2209 SESTKD------DVTPSSRTNSPRRLIKQVALESPPNPNAQLPSQPSADLHTSILKNVQQDLKQN 2267
            |.:..|      |..||::..|...:.::.:  |.|..:|.:|...|   |:||....:| :|:.
Human  1973 SFNILDKLGEQKDPDPSTKGLSTLEMPRESS--SAPTLDAGVPETSS---HSSISTQYRQ-MKRG 2031

  Fly  2268 APEGNGLTTSNSIKR--PRQKLAPFNVDSNAIPDIRSRFAGSWPPPPFQPVDPE--------PD- 2321
            :.  ..||.|..:||  ..|..||.|:             .:|.....||...:        || 
Human  2032 SL--GVLTMSQLMKRQLEHQSSAPHNI-------------SNWDTEQIQPGKRQCNVPTCLNPDL 2081

  Fly  2322 DDDEIGAEASNGHGIHSTPH-------APRGSSRRVGDYT------IVERCSDCGAHIEEYTDEE 2373
            :...:....:....:.|.|.       ||.       ::|      :.::|.||||.:|||.:|.
Human  2082 EGQPLRMRGATKSSLLSAPSIVSMFVPAPE-------EFTDEQPTVMTDKCHDCGAILEEYDEET 2139

  Fly  2374 IGIFIVILGTFIHREPAMAAPFLPEILTMTSRICLSSTHAWQGENGPPLASSAQAVACQFFRCVL 2438
            :|:.||:|.||||..|.:|||.|.:|:....|:..|:|.:.|.|: ..:..:|..||.||.||:.
Human  2140 LGLAIVVLSTFIHLSPDLAAPLLLDIMQSVGRLASSTTFSNQAES-MMVPGNAAGVAKQFLRCIF 2203

  Fly  2439 HQLAPNGIFLQVFQTQMKMKIRHHHFRSIAKALQDFQDLNSTSPIYMVCESLTSKKSLPIEQLPV 2503
            |||||||||.|:||:.:|   .....|::|.:|.||.:|:|.:.:..:.|.|.:||:||.....:
Human  2204 HQLAPNGIFPQLFQSTIK---DGTFLRTLASSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMI 2265

  Fly  2504 -IFRNMAEYLNLQCVPTEAGVGLAVWSQAMQAMESLLRQVIVIMPSLTNAEYMLDIMAATLRLNC 2567
             ...|:|.:  ::.:|.::...|  |:......::...::..::|...:.:..|.||...|:   
Human  2266 RCLENIATF--MEALPMDSPSSL--WTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLK--- 2323

  Fly  2568 VPKT-----LLDPYSKIMAYCVQHTNLEYQTLYELCTLNIRSFSKDRDKNLLCRQMIFEFVQALK 2627
            :|.|     ||:|:||::::.:|:.......|.|||.|..|:|:|:|||..|.|.::.|.:||||
Human  2324 IPSTNATRSLLEPFSKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALK 2388

  Fly  2628 FKSNIPDHNLLTIIGFVLLDAGGTLPP---------GAAPGLPDAAPMMTTNSADCLRQYINDVI 2683
            .||.:||.|||.::.|:..|||..|..         .:.||...||       .:|:|||||:|:
Human  2389 LKSPLPDTNLLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAA-------MECVRQYINEVL 2446

  Fly  2684 DFLADFHTLSKIKNFKNGQTSSGLGEDTLGGVLKGAVAQYLALEMSRGNSRDNKAVSRYLPWLNN 2748
            ||:||.|||:|:|:... ..|..|.|||.||.||..:||..|:::||||.||||||.||||||.:
Human  2447 DFMADMHTLTKLKSHMK-TCSQPLHEDTFGGHLKVGLAQIAAMDISRGNHRDNKAVIRYLPWLYH 2510

  Fly  2749 APSSLQQGPKEFTECVGHMRLLSWLLLGSLTHMALMQRRQETHSIPTPLPQQNSQGTGPAASVHY 2813
            .||::|||||||.|||.|:|||||||||||||.|:.                      |.||   
Human  2511 PPSAMQQGPKEFIECVSHIRLLSWLLLGSLTHNAVC----------------------PNAS--- 2550

  Fly  2814 QHQGVTYSQPVPQEASCHIADHIQVIFAGFAEQSKTSVLHMSSLFHAFTLCQLWTVYLEQMAHNT 2878
                 :...|:|.:|..|:|||:.||..||.||||||||||.||||||...||||||.||.|..|
Human  2551 -----SPCLPIPLDAGSHVADHLIVILIGFPEQSKTSVLHMCSLFHAFIFAQLWTVYCEQSAVAT 2610

  Fly  2879 N--SNAEGSTLGVL--FEFWAKVTPCILQLVSHAKPTVNKDQPQTPLDFQTQSANSKLSEMVNLH 2939
            |  :..|.|...:|  .|||::|||.||||::|                     |..:.|||.||
Human  2611 NLQNQNEFSFTAILTALEFWSRVTPSILQLMAH---------------------NKVMVEMVCLH 2654

  Fly  2940 FLSLLEALKDTNSTVLGKLLPMWSPVLSSQTQ-LSDTLHVRLQNVRDYAPDY-------EEQQTY 2996
            .:||:|||::.|||:..||:|||.|::.|..: ||..|.:|||.::::...:       ..|.:.
Human  2655 VISLMEALQECNSTIFVKLIPMWLPMIQSNIKHLSAGLQLRLQAIQNHVNHHSLRTLPGSGQSSA 2719

  Fly  2997 KSEALLKWLQRLQFKMGQIELQAS-TATQFYSI 3028
            ...||.||||..||||.|:|:|:| .|:|||.:
Human  2720 GLAALRKWLQCTQFKMAQVEIQSSEAASQFYPL 2752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc79NP_650795.2 UNC-79 78..600 CDD:434201 209/541 (39%)
UNC79XP_011535320.1 UNC-79 159..690 CDD:434201 209/541 (39%)

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