DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc79 and Unc79

DIOPT Version :9

Sequence 1:	NP_650795.2	Gene:	unc79 / 42310	FlyBaseID:	FBgn0038693	Length:	3028	Species:	Drosophila melanogaster
Sequence 2:	XP_038968290.1	Gene:	Unc79 / 314401	RGDID:	1311117	Length:	2770	Species:	Rattus norvegicus

Alignment Length:	3280	Identity:	950/3280 - (28%)
Similarity:	1435/3280 - (43%)	Gaps:	818/3280 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AKLRALHEYHVRLLHNVLPAPSGVDIANNIKYFSQTLLTVLKD---------------------- 63
            :|:|.|.|||.|:|||:.|.|||.||||.:||||||||::|..
  Rat    37 SKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSILSRTGKKENQDASNLTVPMTMCLFP 101

  Fly    64 ----------------------------VRTSPHELIRDPLEDPTRMSAYPNLEYGNLYNALTML 100
                                        :|.:|.|  |.|.....::|.||:|:|..||..|..|
  Rat   102 VPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSE--RGPQSRDAQLSDYPSLDYQGLYVTLVTL 164

  Fly   101 IDVAPCIQYGQIVFGKALLQCLSCILPFLDKDLIDNLPYLVSSTISVLPPALHQCIINALCYYIL 165
            :|:.|.:|:||...|:::....:|:||||:.|::..|||.:.||::..||.||:.||..|....|
  Rat   165 LDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDVLSTLPYTMISTLATFPPFLHKDIIEYLSTSFL 229

  Fly   166 PFTITRRSSDE-QECQACQSVSSVIMMVLQYSNNPAHHCQLLECLMTLKHNVVKDILCVVAYGTA 229
            |..|...|..| .......|.||::|:.:||::||.:|||||||||..|..|.||:|.|:|||.:
  Rat   230 PMAILGSSRREGVPAHVNLSASSMLMIAMQYTSNPVYHCQLLECLMKYKQEVWKDLLYVIAYGPS 294

  Fly   230 VSRTSAAKLLFYYWPAFN--ANLFDRKVLLSKLTNDLVPFTCQREHCPNSGNAEAAKVCYDHSIS 292
            ..:..|.::||:|||...  ..:.:.:.|.....|   |..||...|.|:.|..|.|:|.|.|:|
  Rat   295 QVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWN---PIHCQHIECHNAINKPAVKMCIDPSLS 356

  Fly   293 IAYAPDCPPPLYLCIECANEIHREHGSLEFGDILHPMQQVSMVCENKNCRSNEKSAFSICFSTEC 357
            :|.. |.|||||||.||:..|..:|..... |:|.|..::|.:|:.|||.|:.:.|...|||..|
  Rat   357 VALG-DKPPPLYLCEECSERISGDHSEWLI-DVLLPQAEISAICQKKNCSSHVRRAVVTCFSAGC 419

  Fly   358 ASFNGNHPIRYCSQCHSNRHNSRRGGDHVVHRSLQPAWQMDP----------EMQMHMVESVVSL 412
            ...:||.|:|||.:||||.|::..|.....|     .:|..|          |..:..||:|:||
  Rat   420 CGRHGNRPVRYCKRCHSNHHSNEVGATAETH-----LYQTSPPPINTRECGAEELVCAVEAVISL 479

  Fly   413 LREAKPLNFEPGKESSSSESKKNGSGITADNISLE------------ERQRLGRYGIWLLVGRCT 465
            |:||:   |. .::.....:::...|:::.:.||:            :::.|.::|||.||..||
  Rat   480 LKEAE---FH-AEQREHELNRRRQLGLSSSHHSLDNTDFDNKDDDKHDQRLLSQFGIWFLVSLCT 540

  Fly   466 PTADTPVEVLGRILSMLFHWFHVTAYSYDAAGQVESTIEKLKVDHVCNWLKDICRIHYNVFISCL 530
            |:.:||.|.|.|:::|:|.|||.|||..|  .:|.|.:||||...|..|||.:|.:.::|.:.||
  Rat   541 PSENTPTESLARLVAMVFQWFHSTAYMMD--DEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCL 603

  Fly   531 LPHPPEYARVGGHWETLASRTSHLKEGLQRLICLVPYEVITSEIWDYVMPHWMEAITNDVAEKEL 595
            ||.|.|:|||||:|:...|..:.|||||.|::||:||.||:..:|:.:||.|:|||..:|.:.:|
  Rat   604 LPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVISQSVWECIMPEWLEAIRTEVPDNQL 668

  Fly   596 NELKIVLSKILDPEMSPLGFDAKTMYNFVAIRFEKTTAKVQQQALHWLQILTKLEILIPLVQLFA 660
            .|.:.||||:.|.|:.||.|..:.|:.|::.||....:.||:|||.||.:|::|:|.:||..|.:
  Rat   669 KEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSTVQEQALLWLHVLSELDITVPLQLLIS 733

  Fly   661 MFGDGVRIMKYGIQHELMREKDAQSQSLA--------KAPKTPCKESKETKADMANPPRRSSI-S 716
            ||.|||..:|     ||..::.:::..||        .....|.:..:.......:.|.:|.. |
  Rat   734 MFSDGVNSVK-----ELANQRKSRANELAGNLASRRVSVASDPGRRGQHNTLSPFHSPFQSPFRS 793

  Fly   717 PVVEDDSGNTSAISDDEAPTNRHTEFS-TDAEHNLTCCILMLDILLKQMELQDVEQHMGIHTSVC 780
            |:   .|...|...:...|..|..:|. .|.:.||.|.|||.|:|||||:|||....||:..|:.
  Rat   794 PM---RSPFRSPFKNFGHPGGRTIDFDCEDDDMNLNCFILMFDLLLKQMDLQDDGITMGLEHSLS 855

  Fly   781 ENVSRLIKCMVTAARVGLSSHVCA--LKVAECAYCEASIMWHQLATKLVQFMAPLNPVRPPDVPI 843
            :::..:|..:..|...|  ||.|.  .|..||:.|::||:.:|||.:|::.:||
  Rat   856 KDIISIINNVFQAPWGG--SHSCQKDKKATECSLCQSSILCYQLACELLERLAP----------- 907

  Fly   844 EDIIEEEKSSRKSPPESDKEKTRDRDVSLSMAPLPIPLGPLGGFADIFKLDQFFSDDGKIIIMAG 908
                  ::.||...|....|     |..||..|..| |||.|
  Rat   908 ------KEESRLVEPTDSLE-----DSLLSSRPEFI-LGPEG----------------------- 937

  Fly   909 PVPVAVPQPEPHSVGGVLVHMPHVCSNNENGHSVDSNELRKVHATDEIMTATVETVSEQLDLASI 973
                                     ...||
  Rat   938 -------------------------EEEEN----------------------------------- 942

  Fly   974 LPTDRAIARSITLSDADVGSANVSVTKASVMGENGANGGGACGGGENGSGSEEDEEEEDSDDFWH 1038
                                      .|:..|||         .|.....||....:.|::.
  Rat   943 --------------------------PAAKHGEN---------PGNRTVPSEHAAIKNDTER--- 969

  Fly  1039 TSVGKFKFTLDTLPQPLQYIHQLLTEIPTIKKPEILYYVLQCLNTMALHGDALAKAAREQRGFFI 1103
                  ||....||..|:.|:.:..|:...::|:||:.:|.||..:.|||:.|..|.::...|..
  Rat   970 ------KFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNCLKILCLHGECLYTARKDHPQFLA 1028

  Fly  1104 WCQENLLIKNLWELCNAEHSHICQVGVPLLLHCITLPLGSDVFWRVVQEAFHDTDWRVRFTAVER 1168
            :.|:::||.:||.:..:|.|.:..:.||||||.::||.|:|:||.::...|:..||::||.|||:
  Rat  1029 YIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADIFWTIINGNFNSKDWKMRFEAVEK 1093

  Fly  1169 VTVITRFMDSTPLRSEVGLQTALATAFCHLIASMDDINVYVAQRATLYIGTIHDTAIRSLLFCLE 1233
            |.||.||:|...:.....|:.:||.|||..:.:::|:|..||.||.|.:.||...|::.|..||:
  Rat  1094 VAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLD 1158

  Fly  1234 SQFDLFIVDRPVVLQSVYQLHNSLSDRKMLGWEFFLNRFDTLFVEAQINLEKCG-------DISY 1291
            .|||..:.|||.:|..:..||....|...|.||||:|||:||.:|||::|: |.       .|:.
  Rat  1159 FQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLD-CNKEFPFPTTITA 1222

  Fly  1292 LRDLRNSDNGSEALSAKIQKAREALSQS-------DTSGGMAKTLSASFGTKWPYKRTMSAPASM 1349
            :|  .|..|.|:|...||::||.|.::.       |:..|.|::           ||.:|.|.::
  Rat  1223 VR--TNVANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPAES-----------KRALSLPETL 1274

  Fly  1350 APRQDSKFVPEKEKIYSRQVSAPILKRKTSRFGLGQFLGSSSGGASGSSQSVNPATTAASSSRPK 1414
                                        ||:.
  Rat  1275 ----------------------------TSKI--------------------------------- 1278

  Fly  1415 PPPCPVHQSAHTAFPYHTHHHHPHGHHPYPHPHPHHHPHHHAGSSAHVATTATTSAGLVSTHSQS 1479
                ||..:.|.
  Rat  1279 ----PVRLTRHE----------------------------------------------------- 1286

  Fly  1480 HQYLVHCVPPSHHSPMPTLQEAETLLRSQAAADAAAASGSFGGSLGHPGQEAAAVGTGTAGGSAG 1544
                                                             |.|.|:| ||...:.|
  Rat  1287 -------------------------------------------------QSAPALG-GTPEQTPG 1301

  Fly  1545 NPNPHHSFHSHFQKHPSAPNLLPPPPAPSPSPSTLAFPMHCTCDAAPHPHPQVSGAAATGSAANP 1609
            ..:|.
  Rat  1302 QQSPE------------------------------------------------------------ 1306

  Fly  1610 DGHIHSLGGLNDDNLIGLLSRITELEESDRETIHLLVFMLMQFMSRTDQAYPSEEKPMTKTQNIV 1674
                      ||:.:..||.....:   |.:|:|.|:.:||:||:| |::....:....|..|.|
  Rat  1307 ----------NDNTIKDLLPEDAGI---DHQTVHQLITVLMKFMAR-DESSAESDISSAKAFNTV 1357

  Fly  1675 LKHLFLLLGHNQIDKTFHTTPESLRVSAVFNAFLANLPQVLDQNHLIGGLILPSVMQIILYAPNP 1739
            .:||::|||::|.:..|...|:.:|:|..||||:|.:.||:|.|..:|..:||.|:|::.|...|
  Rat  1358 KRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCP 1422

  Fly  1740 TSTSGESYQNIVFNYSLWHLEQYPRRNWLFTLLVVLYKYSYTQPPLSGYVIAGIRLIMNSLRGHF 1804
            ..   ..|.......|||.|:.:.|:.||..|||:||||.|....:|..::..|.:.:|:|...:
  Rat  1423 QL---RHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDVSKTLLHLIHITVNTLNAQY 1484

  Fly  1805 HQCRRIPTTTILDIQGVGGAARSRDVSQPSLGTDPDDKEASPPASPMFPSEGTSAASKSKGNVAF 1869
            |.|:...|...|.......:..|....:.....|..|...:|.......|:...|..|..|....
  Rat  1485 HSCKPHATAGPLYTDNSNISRYSEKEKEEDSVFDESDIHDTPTGPCNKESQTFFARLKRIGGSRM 1549

  Fly  1870 TPKLQHAFRKYNDSSLDADETESELVAIPESD-LSDSTLH------------GSSAPGSFD---- 1917
            .        |.....:....:|.||....|:. |.||.||            .|....|.|
  Rat  1550 V--------KGQPVGMSVQRSEIELSEYRETGALQDSVLHCVREESIQKKKLRSLKQKSLDIGNA 1606

  Fly  1918 DTIHFEDVMPRNRRALEYTEEKSTKSHKSMITTKVGDTY--TTKIKATTTSETLVTTHT-RHSLQ 1979
            |::.|.....|.:..::..:.....:..:.||.:..|.:  :.:..||....|.:..:. ....|
  Rat  1607 DSLLFTLDEHRRKSCIDRCDIDKPPAQAAYITQRQNDHHGRSRQNSATRPDNTEIPKNPGTEGFQ 1671

  Fly  1980 EGVRMIV--TPLVGAETTETAIVSPPVDVHRAVTVRNKSLENAAASTSKMFAAIATNHLKALGAL 2042
            |..|.::  ..|...||.|..:.||.....|. .:....|.:.:.|..:..:.::|:...:| ..
  Rat  1672 ETRRPVIPEVRLNCMETFEVRVDSPGKPAPRE-DLDLIDLSSDSTSGPEKHSILSTSDSDSL-VF 1734

  Fly  2043 QDMP--AAVERKAASSSGSGSRSANGSGNGSGGSAPA---------------AIQASSSAAASKP 2090
            :.:|  ..||.........|:....|:...|..|.|:               :::..|...:||.
  Rat  1735 EPLPPLRIVESDEEEMMNQGNGGPLGNNAASSPSIPSQPSVLSLSTTPLVQVSVEDCSKDFSSKD 1799

  Fly  2091 IGRHKTIVECSAGNSSSSADDSRQKKSQTKSLRRTDKNYGSPDSPLSKMSVMPN----PRDEMD- 2150
            .|.|:::  .:..::.::.||....:..:||....:...|||.:...|..::..    |...:|
  Rat  1800 SGNHQSV--SNEDSTVTALDDLMDSEELSKSEELREFISGSPLTLKQKRDLLQKSFAVPETSVDY 1862

  Fly  2151 --ESMQSLPPPKSIA---ALEIP-------TPERLLPIGTQDTVATLVERV-RDGLNLPD----- 2197
              |..|:...|.|.|   .|::|       ..||..|....||......:| .||....:
  Rat  1863 NPEPGQAEEKPTSGAKTVLLKVPEDGENLTESERPNPSAESDTEQNPERKVEEDGAEESEFKIQI 1927

  Fly  2198 -----------ISHLKQDSLDVSESTKDD-----------VTPSSRTNSPRRLIKQVALESPPNP 2240
                       :|.::::.||:|.:..|.           |.||::..|...:.::.:  |.|..
  Rat  1928 VPRQRKQRKIAVSAIQREYLDISFNILDKLGEQKDPVFPFVDPSAKGLSTLEMPRESS--SAPTL 1990

  Fly  2241 NAQLPSQPSADLHTSILKNVQQDLKQNAPEGNGLTTSNSIKR--PRQKLAPFNVDSNAIPDIRSR 2303
            .|..|...|   |:||....:| :|:.:.  ..||.|..:||  ..|..||.|:
  Rat  1991 EAGAPETSS---HSSISTQYRQ-MKRGSL--GVLTMSQLMKRQLEHQSSAPHNI----------- 2038

  Fly  2304 FAGSWPPPPFQPVDPE--------PD-DDDEIGAEASNGHGIHSTPH-------APRGSSRRVGD 2352
              .||.....||...:        || :...:....:....:.|.|.       ||.       :
  Rat  2039 --SSWDTEQIQPGKGQCNVPMCLNPDLEGQPLRTRGATKSSLLSAPSIASMFVPAPE-------E 2094

  Fly  2353 YT------IVERCSDCGAHIEEYTDEEIGIFIVILGTFIHREPAMAAPFLPEILTMTSRICLSST 2411
            :|      :.::|.||||.:|||.:|.:|:.||:|.||||..|.:|||.|.:|:....|:..|:|
  Rat  2095 FTEEQPTVMADKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDLAAPLLLDIMQSVGRLASSTT 2159

  Fly  2412 HAWQGEN-----------------------GPPLASS------------AQAVACQFFRCVLHQL 2441
            .:.|.|:                       ||.|..|            |..||.||.||:.|||
  Rat  2160 FSNQAESEQDRWTKLQYSEPSLQIMAHTLAGPSLVFSSLFEHSMMVPGNAAGVAKQFLRCIFHQL 2224

  Fly  2442 APNGIFLQVFQTQMKMKIRHHHFRSIAKALQDFQDLNSTSPIYMVCESLTSKKSLPIEQLPV-IF 2505
            ||||||.|:||:.:|   .....|::|.:|.||.:|:|.:.:..:.|.|.:||:||.....: ..
  Rat  2225 APNGIFPQLFQSAIK---DGTFLRTLATSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCL 2286

  Fly  2506 RNMAEYLNLQCVPTEAGVGLAVWSQAMQAMESLLRQVIVIMPSLTNAEYMLDIMAATLRLNCVPK 2570
            .|:|.:  ::.:|.::...|  |:......::...::..::|...:.:..|.||...|:   :|.
  Rat  2287 ENIATF--MEALPMDSPSSL--WTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLK---IPS 2344

  Fly  2571 T-----LLDPYSKIMAYCVQHTNLEYQTLYELCTLNIRSFSKDRDKNLLCRQMIFEFVQALKFKS 2630
            |     ||:|:||::::.:|:.......|.|||.|..|:|:|:|||..|.|.::.|.:||||.||
  Rat  2345 TNATRSLLEPFSKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKS 2409

  Fly  2631 NIPDHNLLTIIGFVLLDAGGTLPP---------GAAPGLPDAAPMMTTNSADCLRQYINDVIDFL 2686
            .:||.|||.::.|:..|||..|..         .:.||...||       .:|:|||:::|:||:
  Rat  2410 PLPDTNLLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAA-------MECIRQYVSEVLDFM 2467

  Fly  2687 ADFHTLSKIKNFKNGQTSSGLGEDTLGGVLKGAVAQYLALEMSRGNSRDNKAVSRYLPWLNNAPS 2751
            ||.|||:|:|:... ..|..|.|||.||.||..:||..|:|:||||.||||||.||||||.:.||
  Rat  2468 ADMHTLTKLKSHMK-TCSQPLHEDTFGGHLKVGLAQIAAMEISRGNHRDNKAVIRYLPWLYHPPS 2531

  Fly  2752 SLQQGPKEFTECVGHMRLLSWLLLGSLTHMALMQRRQETHSIPTPLPQQNSQGTGPAASVHYQHQ 2816
            ::|||||||.|||.|:|||||||||||||.|:.                      |.||
  Rat  2532 AMQQGPKEFIECVSHIRLLSWLLLGSLTHNAVC----------------------PNAS------ 2568

  Fly  2817 GVTYSQPVPQEASCHIADHIQVIFAGFAEQSKTSVLHMSSLFHAFTLCQLWTVYLEQ--MAHNTN 2879
              :...|:|.:|..|||||:.||..||.|||||.||||.||||||...||||||.||  :|.|..
  Rat  2569 --SPCLPIPLDAGSHIADHLIVILIGFPEQSKTCVLHMCSLFHAFIFAQLWTVYCEQSAVATNVQ 2631

  Fly  2880 SNAEGSTLGVL--FEFWAKVTPCILQLVSHAKPTVNKDQPQTPLDFQTQSANSKLSEMVNLHFLS 2942
            :..|.|...:|  .|||::|||.||||::|                     |..:.|||.||.:|
  Rat  2632 NQNEFSFTAILTALEFWSRVTPSILQLMAH---------------------NKVMVEMVCLHVIS 2675

  Fly  2943 LLEALKDTNSTVLGKLLPMWSPVLSSQTQ-LSDTLHVRLQNVRDYAPDY-------EEQQTYKSE 2999
            |:|||::.|||:..||:|||.|::.|.|: ||..|.:|||.:::....:       ..|.:....
  Rat  2676 LMEALQECNSTIFVKLIPMWLPMIQSNTKYLSAGLQLRLQAIQNNVNHHSLRTLPGSGQSSAGLA 2740

  Fly  3000 ALLKWLQRLQFKMGQIELQAS-TATQFYSI 3028
            ||.||||..||||.|:|:|:| .|:|||.:
  Rat  2741 ALRKWLQCTQFKMAQVEIQSSEAASQFYPL 2770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc79	NP_650795.2	UNC-79	78..600	CDD:291442	209/546 (38%)
Unc79	XP_038968290.1	UNC-79	141..672	CDD:405466	209/546 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343771
Domainoid	1	1.000	867	1.000	Domainoid score	I52
eggNOG	1	0.900	-	-		E1_KOG4820
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41397
Inparanoid	1	1.050	1226	1.000	Inparanoid score	I171
OMA	1	1.010	-	-		QHG50035
OrthoDB	1	1.010	-	-		D51194at33208
OrthoFinder	1	1.000	-	-		FOG0008504
OrthoInspector	1	1.000	-	-		oto96828
orthoMCL	1	0.900	-	-		OOG6_106602
Panther	1	1.100	-	-	LDO	PTHR21696
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6459
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.900