Protein Alignment unc79 and Unc79

DIOPT Version :9

• Sequence 1: NP_650795.2
• Gene: unc79 / 42310
• FlyBaseID: FBgn0038693
• Length: 3028
• Species: Drosophila melanogaster
• Sequence 2: XP_036013237.1
• Gene: Unc79 / 217843
• MGIID: 2684729
• Length: 2739
• Species: Mus musculus
• Alignment Length: 3259
• Identity: 947/3259 - (29%)
• Similarity: 1430/3259 - (43%)
• Gaps: 807/3259 - (24%)

  Fly    21 AKLRALHEYHVRLLHNVLPAPSGVDIANNIKYFSQTLLTVLKD---------------------- 63
            :|:|.|.|||.|:|||:.|.|||.||||.:||||||||::|..
Mouse    37 SKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSILSRTGKKENQDASNLTVPMTMCLFP 101

  Fly    64 ----------------------------VRTSPHELIRDPLEDPTRMSAYPNLEYGNLYNALTML 100
                                        :|.:|.|  |.|.....::|.||:|:|..||..|..|
Mouse   102 VPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSE--RGPQSRDAQLSDYPSLDYQGLYVTLVTL 164

  Fly   101 IDVAPCIQYGQIVFGKALLQCLSCILPFLDKDLIDNLPYLVSSTISVLPPALHQCIINALCYYIL 165
            :|:.|.:|:||...|:::....:|:||||:.|::..|||.:.||::..||.||:.||..|....|
Mouse   165 LDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDVLSTLPYTMISTLATFPPFLHKDIIEYLSTSFL 229

  Fly   166 PFTITRRSSDE-QECQACQSVSSVIMMVLQYSNNPAHHCQLLECLMTLKHNVVKDILCVVAYGTA 229
            |..|...|..| .......|.||::|:.:||::||.:|||||||||..|..|.||:|.|:|||.:
Mouse   230 PMAILGSSGREGVPAHVNLSASSMLMIAMQYTSNPVYHCQLLECLMKYKQEVWKDLLYVIAYGPS 294

  Fly   230 VSRTSAAKLLFYYWPAFN--ANLFDRKVLLSKLTNDLVPFTCQREHCPNSGNAEAAKVCYDHSIS 292
            ..:..|.::||:|||...  ..:.:.:.|.....|   |..||...|.|:.|..|.|:|.|.|:|
Mouse   295 QVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWN---PIHCQHIECHNAINKPAVKMCIDPSLS 356

  Fly   293 IAYAPDCPPPLYLCIECANEIHREHGSLEFGDILHPMQQVSMVCENKNCRSNEKSAFSICFSTEC 357
            :|.. |.|||||||.||:..|..:|..... |:|.|..::|.:|:.|||.|:.:.|...|||..|
Mouse   357 VALG-DKPPPLYLCEECSERISGDHSEWLI-DVLLPQAEISAICQKKNCSSHVRRAVVTCFSAGC 419

  Fly   358 ASFNGNHPIRYCSQCHSNRHNSRRGGDHVVHRSLQPAWQMDP----------EMQMHMVESVVSL 412
            ...:||.|:|||.:||||.|::..|.....|     .:|..|          |..:..||:|:||
Mouse   420 CGRHGNRPVRYCKRCHSNHHSNEVGATAETH-----LYQTSPPPINTRECGAEELVCAVEAVISL 479

  Fly   413 LREAKPLNFEPGKESSSSESKKNGSGITADNISLE------------ERQRLGRYGIWLLVGRCT 465
            |:||:   |. .::.....:::...|:::.:.||:            :::.|.::|||.||..||
Mouse   480 LKEAE---FH-AEQREHELNRRRQLGLSSSHHSLDNTDFDNKDDDKHDQRLLSQFGIWFLVSLCT 540

  Fly   466 PTADTPVEVLGRILSMLFHWFHVTAYSYDAAGQVESTIEKLKVDHVCNWLKDICRIHYNVFISCL 530
            |:.:||.|.|.|:::|:|.|||.|||..|  .:|.|.:||||...|..|||.:|.:.::|.:.||
Mouse   541 PSENTPTESLARLVAMVFQWFHSTAYMMD--DEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCL 603

  Fly   531 LPHPPEYARVGGHWETLASRTSHLKEGLQRLICLVPYEVITSEIWDYVMPHWMEAITNDVAEKEL 595
            ||.|.|:|||||:|:...|..:.|||||.|::||:||.||:..:|:.:||.|:|||..:|.:.:|
Mouse   604 LPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVISQSVWECIMPEWLEAIRTEVPDNQL 668

  Fly   596 NELKIVLSKILDPEMSPLGFDAKTMYNFVAIRFEKTTAKVQQQALHWLQILTKLEILIPLVQLFA 660
            .|.:.||||:.|.|:.||.|..:.|:.|::.||....:.||:|||.||.:|::|:|.:||..|.:
Mouse   669 KEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSTVQEQALLWLHVLSELDITVPLQLLIS 733

  Fly   661 MFGDGVRIMKYGIQHELMREKDAQSQSLA--------KAPKTPCKESKETKADMANPPRRSSI-S 716
            ||.|||..:|     ||..::.:::..||        .....|.:..:.......:.|.:|.. |
Mouse   734 MFSDGVNSVK-----ELANQRKSRANELAGNLASRRVSVASDPGRRGQHNTLSPFHSPFQSPFRS 793

  Fly   717 PVVEDDSGNTSAISDDEAPTNRHTEFS-TDAEHNLTCCILMLDILLKQMELQDVEQHMGIHTSVC 780
            |:   .|...|...:...|..|..:|. .|.:.||.|.|||.|:|||||||||....||:..|:.
Mouse   794 PM---RSPFRSPFKNFGHPGGRTIDFDCEDDDMNLNCFILMFDLLLKQMELQDDGITMGLEHSLS 855

  Fly   781 ENVSRLIKCMVTAARVGLSSHVCA--LKVAECAYCEASIMWHQLATKLVQFMAPLNPVRPPDVPI 843
            :::..:|..:..|...|  ||.|.  .|..||..|::||:.:|||.:|::.:||
Mouse   856 KDIISIINNVFQAPWGG--SHSCQKDKKATECNLCQSSILCYQLACELLERLAP----------- 907

  Fly   844 EDIIEEEKSSRKSPPESDKEKTRDRDVSLSMAPLPIPLGPLGGFADIFKLDQFFSDDGKIIIMAG 908
                  ::.||...|....|     |..||..|..| |||.|
Mouse   908 ------KEESRLVEPTDSLE-----DSLLSSRPEFI-LGPEG----------------------- 937

  Fly   909 PVPVAVPQPEPHSVGGVLVHMPHVCSNNENGHSVDSNELRKVHATDEIMTATVETVSEQLDLASI 973
                                     ...||
Mouse   938 -------------------------EEEEN----------------------------------- 942

  Fly   974 LPTDRAIARSITLSDADVGSANVSVTKASVMGENGANGGGACGGGENGSGSEEDEEEEDSDDFWH 1038
                                      .|:..|||         .|.....||....:.|::.
Mouse   943 --------------------------PAAKHGEN---------PGNRTVPSEHAAIKNDTER--- 969

  Fly  1039 TSVGKFKFTLDTLPQPLQYIHQLLTEIPTIKKPEILYYVLQCLNTMALHGDALAKAAREQRGFFI 1103
                  ||....||..|:.|:.:..|:...::|:||:.:|.||..:.|||:.|..|.::...|..
Mouse   970 ------KFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNCLKILCLHGECLYTARKDHPQFLA 1028

  Fly  1104 WCQENLLIKNLWELCNAEHSHICQVGVPLLLHCITLPLGSDVFWRVVQEAFHDTDWRVRFTAVER 1168
            :.|:::||.:||.:..:|.|.:..:.||||||.::||.|:|:||.::...|:..||::||.|||:
Mouse  1029 YIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADIFWTIINGNFNSKDWKMRFEAVEK 1093

  Fly  1169 VTVITRFMDSTPLRSEVGLQTALATAFCHLIASMDDINVYVAQRATLYIGTIHDTAIRSLLFCLE 1233
            |.||.||:|...:.....|:.:||.|||..:.:::|:|..||.||.|.:.||...|::.|..||:
Mouse  1094 VAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLD 1158

  Fly  1234 SQFDLFIVDRPVVLQSVYQLHNSLSDRKMLGWEFFLNRFDTLFVEAQINLEKCG-------DISY 1291
            .|||..:.|||.:|..:..||....|...|.||||:|||:||.:|||::|: |.       .|:.
Mouse  1159 FQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLD-CNKEFPFPTTITA 1222

  Fly  1292 LRDLRNSDNGSEALSAKIQKAREALSQS-------DTSGGMAKTLSASFGTKWPYKRTMSAPASM 1349
            :|  .|..|.|:|...||::||.|.::.       |:..|.|::           ||.:|.|.::
Mouse  1223 VR--TNVANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPAES-----------KRALSLPETL 1274

  Fly  1350 APRQDSKFVPEKEKIYSRQVSAPILKRKTSRFGLGQFLGSSSGGASGSSQSVNPATTAASSSRPK 1414
                                        ||:.
Mouse  1275 ----------------------------TSKI--------------------------------- 1278

  Fly  1415 PPPCPVHQSAHTAFPYHTHHHHPHGHHPYPHPHPHHHPHHHAGSSAHVATTATTSAGLVSTHSQS 1479
                ||..:.|.
Mouse  1279 ----PVRLTRHE----------------------------------------------------- 1286

  Fly  1480 HQYLVHCVPPSHHSPMPTLQEAETLLRSQAAADAAAASGSFGGSLGHPGQEAAAVGTGTAGGSAG 1544
                                                             |.|.|:| ||...:.|
Mouse  1287 -------------------------------------------------QSAPALG-GTPEQTPG 1301

  Fly  1545 NPNPHHSFHSHFQKHPSAPNLLPPPPAPSPSPSTLAFPMHCTCDAAPHPHPQVSGAAATGSAANP 1609
            ..:|.
Mouse  1302 QQSPE------------------------------------------------------------ 1306

  Fly  1610 DGHIHSLGGLNDDNLIGLLSRITELEESDRETIHLLVFMLMQFMSRTDQAYPSEEKPMTKTQNIV 1674
                      ||:.:..||.....:   |.:|:|.|:.:||:||:| |::....:....|..|.|
Mouse  1307 ----------NDNTIKDLLPEDAGI---DHQTVHQLITVLMKFMAR-DESSAESDISSAKAFNTV 1357

  Fly  1675 LKHLFLLLGHNQIDKTFHTTPESLRVSAVFNAFLANLPQVLDQNHLIGGLILPSVMQIILYAPNP 1739
            .:||::|||::|.:..|...|:.:|:|..||||:|.:.||:|.|..:|..:||.|:|::.|...|
Mouse  1358 KRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCP 1422

  Fly  1740 TSTSGESYQNIVFNYSLWHLEQYPRRNWLFTLLVVLYKYSYTQPPLSGYVIAGIRLIMNSLRGHF 1804
            ..   ..|.......|||.|:.:.|:.||..|||:||||.|....:|..::..|.:.:|:|...:
Mouse  1423 QL---RHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDVSKTLLHLIHITVNTLNAQY 1484

  Fly  1805 HQCRRIPTTTILDIQGVGGAARSRDVSQPSLGTDPDDKEASPPASPMFPSEGTSAASKSKGNVAF 1869
            |.|:...|...|.......:..|....:.....|..|...:|.......|:...|..|..|....
Mouse  1485 HSCKPHATAGPLYTDNSNISRYSEKEKEEDSVFDESDIHDTPTGPCNKESQTFFARLKRIGGSRM 1549

  Fly  1870 TPKLQHAFRKYNDSSLDADETESELVAIPESD-LSDSTLH------------GSSAPGSFD---- 1917
            .        |.....::...:|.||....|:. |.||.||            .|....|.|
Mouse  1550 V--------KGQPVGMNVQRSEIELAEYRETGALQDSVLHCVREESIQKKKLRSLKQKSLDIGNA 1606

  Fly  1918 DTIHFEDVMPRNRRALEYTEEKSTKSHKSMITTKVGDTY--TTKIKATTTSETLVTTHTRHSLQE 1980
            |::.|.....|.:..::..:.....:..:.|:.:..|.:  :.:..||....|.:   .::...|
Mouse  1607 DSLLFTLDEHRRKSCIDRCDIDKPPAQAAYISQRQNDHHGRSRQNSATRPDNTEI---PKNPGTE 1668

  Fly  1981 GVRMIVTPLVG------AETTETAIVSPP----------VDVHRAVT--VRNKSLENAAASTSKM 2027
            |.:.|..|::.      .||.|..:.||.          :|:....|  ....|:.:.:.|.|.:
Mouse  1669 GFQEIRRPVIPEVRLNCMETFEVRVDSPGKPAPREDLDLIDLSSDSTSGPEKHSILSTSDSDSLV 1733

  Fly  2028 FAAIATNHLKALGALQDMPAAVERKAASSSGSGSRSANGSGNGSGGSAPAAIQAS---------- 2082
            |        :.|..|:.:.:..|.:..:....|:...|.:.:.|..|.|:.:..|
Mouse  1734 F--------EPLPPLRIVESDEEEEMMNQGNGGALGNNAASSPSIPSQPSVLSLSTTPLVQVSVE 1790

  Fly  2083 --SSAAASKPIGRHKTIVECSAGNSSS---SADDSRQKKSQTKSLRRTDKNYGSP---------- 2132
              |...:||..|.|:     ||.|..|   :.||....:..:||....:...|||
Mouse  1791 DCSKDFSSKDSGNHQ-----SASNEDSTIAALDDLTDSEELSKSEELREFASGSPLTLKQKRDLL 1850

  Fly  2133 --DSPLSKMSVMPNPRDEMDESMQSLPPPKSIAALEIPTP---ERLLPIGTQDTVA--------- 2183
              .|.:.:|||..||.....|......|...:..:.:..|   |.|:.....:|.|
Mouse  1851 QKSSAVPEMSVDYNPEPSPAEEKPGQTPTSGVKTVLLKVPEDGENLIESEKPNTSAESDTEQNPE 1915

  Fly  2184 ---------------TLVERVRDGLNLPDISHLKQDSLDVS-------ESTKDDVTPSSRTNSPR 2226
                           .:|.|.|....:. :|.::::.||:|       ...||.|.|.:..::..
Mouse  1916 RKVEEDGAEESEFKIQIVPRQRKQRKIA-VSAIQREYLDISFNILDKLGEQKDPVFPFADPSAKG 1979

  Fly  2227 RLIKQVALESPPNPNAQLPSQPSADLHTSILKNVQQDLKQNAPEGNGLTTSNSIKR--PRQKLAP 2289
            ....::..||...|..: ...|....|:||....:| :|:.:.  ..||.|..:||  ..|..||
Mouse  1980 LSTLEMPRESSSAPTLE-AGAPETSSHSSISTQYRQ-MKRGSL--GVLTMSQLMKRQLEHQSSAP 2040

  Fly  2290 FNVDSNAIPDIRSRFAGSWPPPPFQPVDPE--------PD-DDDEIGAEASNGHGIHSTPH---- 2341
            .|:             .||.....||...:        || :...:....:....:.|.|.
Mouse  2041 HNI-------------SSWDTEQIQPGKRQCNVPMCLNPDLEGQPLRTRGATKSSLLSAPSIASM 2092

  Fly  2342 ---APRGSSRRVGDYT------IVERCSDCGAHIEEYTDEEIGIFIVILGTFIHREPAMAAPFLP 2397
               ||.       ::|      :.::|.||||.:|||.:|.:|:.||:|.||||..|.:|||.|.
Mouse  2093 FVPAPE-------EFTEEQPTVMADKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDLAAPLLL 2150

  Fly  2398 EILTMTSRICLSSTHAWQGENGPPLASSAQAVACQFFRCVLHQLAPNGIFLQVFQTQMKMKIRHH 2462
            :|:....|:..|:|.:.|.|: ..:..:|..||.||.||:.|||||||||.|:||:.:|   ...
Mouse  2151 DIMQSVGRLASSTTFSNQAES-MMVPGNAAGVAKQFLRCIFHQLAPNGIFPQLFQSAIK---DGT 2211

  Fly  2463 HFRSIAKALQDFQDLNSTSPIYMVCESLTSKKSLPIEQLPV-IFRNMAEYLNLQCVPTEAGVGLA 2526
            ..|::|.:|.||.:|:|.:.:..:.|.|.:||:||.....: ...|:|.:  ::.:|.::...|
Mouse  2212 FLRTLATSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCLENIATF--MEALPMDSPSSL- 2273

  Fly  2527 VWSQAMQAMESLLRQVIVIMPSLTNAEYMLDIMAATLRLNCVPKT-----LLDPYSKIMAYCVQH 2586
             |:......::...::..::|...:.:..|.||...|:   :|.|     ||:|:||::::.:|:
Mouse  2274 -WTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLK---IPSTNATRSLLEPFSKLLSFVIQN 2334

  Fly  2587 TNLEYQTLYELCTLNIRSFSKDRDKNLLCRQMIFEFVQALKFKSNIPDHNLLTIIGFVLLDAGGT 2651
            .......|.|||.|..|:|:|:|||..|.|.::.|.:||||.||.:||.|||.::.|:..|||..
Mouse  2335 AVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKSPLPDTNLLLLVQFICADAGTK 2399

  Fly  2652 LPP---------GAAPGLPDAAPMMTTNSADCLRQYINDVIDFLADFHTLSKIKNFKNGQTSSGL 2707
            |..         .:.||...||       .:|:|||:::|::|:||.|||:|:|:... ..|..|
Mouse  2400 LAESTILSKQMIASVPGCGTAA-------MECIRQYVSEVLEFMADMHTLTKLKSHMK-TCSQPL 2456

  Fly  2708 GEDTLGGVLKGAVAQYLALEMSRGNSRDNKAVSRYLPWLNNAPSSLQQGPKEFTECVGHMRLLSW 2772
            .|||.||.||..:||..|:|:||||.||||||.||||||.:.||::|||||||.|||.|:|||||
Mouse  2457 HEDTFGGHLKVGLAQIAAMEISRGNHRDNKAVIRYLPWLYHPPSAMQQGPKEFIECVSHIRLLSW 2521

  Fly  2773 LLLGSLTHMALMQRRQETHSIPTPLPQQNSQGTGPAASVHYQHQGVTYSQPVPQEASCHIADHIQ 2837
            ||||||||.|:.                      |.||        :...|:|.:|..|||||:.
Mouse  2522 LLLGSLTHNAVC----------------------PNAS--------SPCLPIPLDAGSHIADHLI 2556

  Fly  2838 VIFAGFAEQSKTSVLHMSSLFHAFTLCQLWTVYLEQ--MAHNTNSNAEGSTLGVL--FEFWAKVT 2898
            ||..||.|||||.||||.||||||...||||||.||  :|.|..:..|.|...:|  .|||::||
Mouse  2557 VILIGFPEQSKTCVLHMCSLFHAFIFAQLWTVYCEQSAVATNVQNQNEFSFTAILTALEFWSRVT 2621

  Fly  2899 PCILQLVSHAKPTVNKDQPQTPLDFQTQSANSKLSEMVNLHFLSLLEALKDTNSTVLGKLLPMWS 2963
            |.||||::|                     |..:.|||.||.:||:|||::.|||:..||:|||.
Mouse  2622 PSILQLMAH---------------------NKVMVEMVCLHVISLMEALQECNSTIFVKLIPMWL 2665

  Fly  2964 PVLSSQTQ-LSDTLHVRLQNVRDYAPDY-------EEQQTYKSEALLKWLQRLQFKMGQIELQAS 3020
            |::.|.|: ||..|.:|||.:::....:       ..|.:....||.||||..||||.|:|:|:|
Mouse  2666 PMIQSNTKHLSAGLQLRLQAIQNNVNHHSLRTLPGSGQSSAGLAALRKWLQCTQFKMAQVEIQSS 2730

  Fly  3021 -TATQFYSI 3028
             .|:|||.:
Mouse  2731 EAASQFYPL 2739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc79	NP_650795.2	UNC-79	78..600	CDD:291442	209/546 (38%)
Unc79	XP_036013237.1	UNC-79	141..672	CDD:405466	209/546 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839927
Domainoid	1	1.000	866	1.000	Domainoid score	I54
eggNOG	1	0.900	-	-		E1_KOG4820
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41397
Inparanoid	1	1.050	1325	1.000	Inparanoid score	I148
Isobase	1	0.950	-	0	Normalized mean entropy	S6942
OMA	1	1.010	-	-		QHG50035
OrthoDB	1	1.010	-	-		D51194at33208
OrthoFinder	1	1.000	-	-		FOG0008504
OrthoInspector	1	1.000	-	-		oto93287
orthoMCL	1	0.900	-	-		OOG6_106602
Panther	1	1.100	-	-	LDO	PTHR21696
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2887
SonicParanoid	1	1.000	-	-		X6459
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750