DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5250 and ATP1B4

DIOPT Version :9

Sequence 1:	NP_650793.1	Gene:	CG5250 / 42308	FlyBaseID:	FBgn0038691	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001135919.1	Gene:	ATP1B4 / 23439	HGNCID:	808	Length:	357	Species:	Homo sapiens

Alignment Length:	314	Identity:	58/314 - (18%)
Similarity:	105/314 - (33%)	Gaps:	123/314 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VAEYLYRRSIRTRNADPE--MTVCR-----FIKLLLYFIGFFFVLGVFTTGL-ALVMIANHIYPD 81
            ::|||:         |||  |.:.|     .:.||:||..:..:..|.|..: .|.:..:...|.
Human    89 MSEYLW---------DPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIPT 144

  Fly    82 RPGCKKFPGLATAPGHH-------------------------------VGDQKQIMWSPNNI--- 112
            .....|.||:...|..|                               :.::..:...|...
Human   145 FTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQ 209

  Fly   113 -------KDVANIQRAIMRTVKRYGLEGPKRLMGCNIDDSWGYMSGTPCILIKITQALGFQAVTY 170
                   |.....:|:.::...  |||.|          ::||.:|.||||:|:.:.:||:
Human   210 DGNEDEDKKACQFKRSFLKNCS--GLEDP----------TFGYSTGQPCILLKMNRIVGFR---- 258

  Fly   171 DDALTLPEYAPDELFDYVVGLGSEERFNRIWVSCQVIE-PRVDIQ-FDYHPVRFFDAEELFTSGN 233
                  ||            ||     :.:.|||:|.. ...||: ..|:|
Human   259 ------PE------------LG-----DPVKVSCKVQRGDENDIRSISYYP-------------- 286

  Fly   234 VFLNESSDDDGPTYKEDPRLRRI------ISVRLSNIPINEDIQIHCKAWAKNI 281
                ||:..|...|....:|..:      :::..:::..|:.:.:.|:...|.:
Human   287 ----ESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGV 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5250	NP_650793.1	Na_K-ATPase	<143..281	CDD:298651	30/145 (21%)
ATP1B4	NP_001135919.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..80
ATP1B4	NP_001135919.1	Na_K-ATPase	82..351	CDD:306737	58/314 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160440
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11523
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840