DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vib and LPIN2

DIOPT Version :9

Sequence 1:	NP_001262726.1	Gene:	vib / 42306	FlyBaseID:	FBgn0267975	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	XP_005258234.1	Gene:	LPIN2 / 9663	HGNCID:	14450	Length:	933	Species:	Homo sapiens

Alignment Length:	232	Identity:	45/232 - (19%)
Similarity:	76/232 - (32%)	Gaps:	77/232 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AEASKENTGGGEGIEVLKN----EPFEDFPLLGGKYNSGQYTYKIYHLQSKVPAYIRLLAPK-GS 85
            |..::.::...||.:.|:.    :|....||..|...|    ||         ..:||.:.: ..
Human   634 ARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTS----YK---------KSLRLSSDQIAK 685

  Fly    86 LEIHEEAWNAYPYCRTIITNPGYMDKNFKIDIYSQHIENDLGTVDNVHELTPDKLKVREIVHIDI 150
            |::|:                |..|..|.|....|......||                 :::..
Human   686 LKLHD----------------GPNDVVFSITTQYQGTCRCAGT-----------------IYLWN 717

  Fly   151 ANDPVLPADYKPDEDPTTYQSKKTGR-GPLVGSDW------KKHVNPVMTCYKLVTCEFKWFGLQ 208
            .||.::.:|.    |.|..:|...|: .|.:|.||      |.:.:.....||.:.|..:..|:.
Human   718 WNDKIIISDI----DGTITKSDALGQILPQLGKDWTHQGIAKLYHSINENGYKFLYCSARAIGMA 778

  Fly   209 TRVENF---------------IQKSERRLFTNFHRQV 230
            .....:               :..|...||:.|||:|
Human   779 DMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREV 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vib	NP_001262726.1	SRPBCC_PITPNA-B_like	2..261	CDD:176897	45/232 (19%)
LPIN2	XP_005258234.1	Lipin_N	38..143	CDD:282436
		Lipin_mid	506..596	CDD:293481
		LNS2	674..899	CDD:285447	34/179 (19%)
		AF1Q	<913..>932	CDD:259154
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900