DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vib and PITPNB

DIOPT Version :9

Sequence 1:	NP_001262726.1	Gene:	vib / 42306	FlyBaseID:	FBgn0267975	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	XP_011528354.1	Gene:	PITPNB / 23760	HGNCID:	9002	Length:	274	Species:	Homo sapiens

Alignment Length:	277	Identity:	167/277 - (60%)
Similarity:	209/277 - (75%)	Gaps:	15/277 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKEFRVTLPLTVEEYQVAQLFSVAEASKENTGGGEGIEVLKNEPFEDFPLLGGKYNSGQYTYKIY 67
            :::.||.||.:|:||||.||:|||||||..||||||||||||||:|.    .|:  .||||:|||
Human     6 MEKCRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEK----DGE--KGQYTHKIY 64

  Fly    68 HLQSKVPAYIRLLAPKGSLEIHEEAWNAYPYCRTIITNPGYMDKNFKIDIYSQHIENDLGTVDNV 132
            ||:|||||::|::||:|||..||:|||||||||||:||. ||..:|.|.|.:.| :.||||::||
Human    65 HLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNE-YMKDDFFIKIETWH-KPDLGTLENV 127

  Fly   133 HELTPDKLKVREIVHIDIAN-DPVLPADYKPDEDPTTYQSKKTGRGPLVGSDWKKHVN-----PV 191
            |.|.|:..|..||||||||: ..|.|||||.||||..:||.||.|||| |.:|||.:.     |.
Human   128 HGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPL-GPNWKKELANSPDCPQ 191

  Fly   192 MTCYKLVTCEFKWFGLQTRVENFIQKSERRLFTNFHRQVFCSTDRWYGLTMEDIRAIEDQTKEEL 256
            |..|||||.:|||:|||::|||||||.|:|:|||||||:||..|:|..|||||||.:||:|::||
Human   192 MCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKEL 256

  Fly   257 DKARQVGEVRGMRADAD 273
            :..|..|:|||..|.:|
Human   257 ETLRNQGQVRGTSAASD 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vib	NP_001262726.1	SRPBCC_PITPNA-B_like	2..261	CDD:176897	160/263 (61%)
PITPNB	XP_011528354.1	SRPBCC_PITPNA-B_like	10..261	CDD:176897	160/259 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	312	1.000	Domainoid score	I1311
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4533
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2484
Isobase	1	0.950	-	0	Normalized mean entropy	S2729
OMA	1	1.010	-	-		QHG54293
OrthoDB	1	1.010	-	-		D522789at33208
OrthoFinder	1	1.000	-	-		FOG0002025
OrthoInspector	1	1.000	-	-		otm42103
orthoMCL	1	0.900	-	-		OOG6_103092
Panther	1	1.100	-	-	LDO	PTHR10658
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4220
SonicParanoid	1	1.000	-	-		X1329
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820