DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vib and Pitpnm1

DIOPT Version :9

Sequence 1:	NP_001262726.1	Gene:	vib / 42306	FlyBaseID:	FBgn0267975	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_032877.1	Gene:	Pitpnm1 / 18739	MGIID:	1197524	Length:	1243	Species:	Mus musculus

Alignment Length:	261	Identity:	113/261 - (43%)
Similarity:	165/261 - (63%)	Gaps:	14/261 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQIKEFRVTLPLTVEEYQVAQLFSVAEASKENTGG-GEGIEVLKNEPFEDFPLLGGKYNSGQYTY 64
            |.|||:.:.||::::|||||||:.:.:.|:|.:.| |.|:|:|.|.|:.|.|  ||   :||||:
Mouse     1 MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGP--GG---NGQYTH 60

  Fly    65 KIYHLQSKVPAYIRLLAPKGSLEIHEEAWNAYPYCRTIITNPGYMDKNFKIDIYSQHIENDLGTV 129
            |:||:.|.:|.:.|.|.||.:|::.||:||||||.||..|.| :::| |.|:|.:.::. |.|..
Mouse    61 KVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCP-FVEK-FSIEIETYYLP-DGGQQ 122

  Fly   130 DNVHELTPDKLKVREIVHIDIANDPVLPADYKPDEDPTTYQSKKTGRGPLVGSDWKK---HVNPV 191
            .||..|:..:.:.|.:..|||..|.|.|.:||.:|||..|:|.||||||| ..||.:   ...|:
Mouse   123 PNVFNLSGAERRQRIVDTIDIVRDAVAPGEYKAEEDPRLYRSAKTGRGPL-ADDWARTAAQTGPL 186

  Fly   192 MTCYKLVTCEFKWFGLQTRVENFIQK-SERRLFTNFHRQVFCSTDRWYGLTMEDIRAIEDQTKEE 255
            |..|||...||:::|:|.::|.||.. ..||:....|||.:|..|.|..|:|.||||:|::|...
Mouse   187 MCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWIELSMADIRALEEETARM 251

  Fly   256 L 256
            |
Mouse   252 L 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vib	NP_001262726.1	SRPBCC_PITPNA-B_like	2..261	CDD:176897	112/260 (43%)
Pitpnm1	NP_032877.1	SRPBCC_PITPNM1-2_like	1..257	CDD:176898	113/261 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..330
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..679
		DDHD	688..878	CDD:280937
		Peptidase_M14NE-CP-C_like	<963..>995	CDD:304370
		LNS2	1022..1153	CDD:197870
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1206..1243
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810