DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and cry3b

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_009294043.2	Gene:	cry3b / 83780	ZFINID:	ZDB-GENE-010426-5	Length:	640	Species:	Danio rerio

Alignment Length:	523	Identity:	205/523 - (39%)
Similarity:	291/523 - (55%)	Gaps:	46/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDIDDQL 71
            :|.|||.|||||||||||.||...|   .|..|:..|...||..|:|.||.||||.||:|:|..|
Zfish     5 SVHWFRKGLRLHDNPALLEALNGAD---TLRCVYFLDPWFAGASNLGVNRWRFLLQSLEDLDASL 66

  Fly    72 QAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKV 136
            :..   ...|.|..|:||.||.||.::.::.|:..|.|.||...|||.:|:.|..|..::.:.|:
Zfish    67 RKL---NSCLFVIRGQPADIFPRLFKEWKVSRLTFEFDSEPFGKERDAAIKKLACEAGVEVIVKI 128

  Fly   137 SHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQ 201
            ||||:|...:||.|||..||||:.|...|..:..|..|.|            .|:    ..:..:
Zfish   129 SHTLYDLDRIIELNGGQSPLTYKRFQTLVSSMEPPDSPLA------------SPD----RGMMGK 177

  Fly   202 LPTP---EHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQH-AFERGFYLPNQ 254
            ..||   .|.:.||    :.:||    ||.:.|.|||::||..::..|..:.. |::..|..|..
Zfish   178 CVTPISENHRDKYGVPLLEELGFDTEGLAPVVWPGGESEALKRMERHLGPDSTVAWQENFERPKM 242

  Fly   255 ALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFY 319
            ....:..||..:|.:|||||||.|.||..:..|:|.|:       ..|.....:..:::|||:||
Zfish   243 NASPLMASPLGLSPYLRFGCLSCRLFYCKLTQLYKKVK-------KNMNPSISLYDKILWREFFY 300

  Fly   320 TMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTV 384
            |.:.|||.:||||||.||:.|||.: |...|..|...:||||.||..|.||..|||:||..|:.|
Zfish   301 TAATNNPRFDRMEGNPICIRIPWDR-NAEALAKWAEAKTGFPWIDAIMMQLRQEGWIHHLARHAV 364

  Fly   385 ATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVS-SSAFERLLDSSLVTCPVALAKRLD 448
            |.|||||.||.|||.|::.|.:.||||||||.||:|:..| ||.|::...   ..|||...:|:|
Zfish   365 ACFLTRGDLWISWEEGMKVFEELLLDADWSVNAGSWLCHSCSSFFQQFFH---CYCPVGFGRRID 426

  Fly   449 PDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKSLR 513
            |:|.:|::|:|.|.:.|.:::::||....:.|...:|:|||.||:.:::.:.|.:.|:..|:.:.
Zfish   427 PNGDFIRRYLPVLRDFPAKYIYDPWNAPHDVQLAAKCVIGVDYPKPMVNHAEASRLNIERMRQIY 491

  Fly   514 NSL 516
            ..|
Zfish   492 QQL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	202/509 (40%)
		DNA_photolyase	8..175	CDD:279247	74/166 (45%)
		FAD_binding_7	310..510	CDD:281440	90/200 (45%)
cry3b	XP_009294043.2	DNA_photolyase	5..494	CDD:332096	204/521 (39%)
cry3b	XP_009294043.2	FAD_binding_7	293..489	CDD:308829	91/199 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820