DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and cry5

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_571863.1	Gene:	cry5 / 83776	ZFINID:	ZDB-GENE-010426-8	Length:	519	Species:	Danio rerio

Alignment Length:	543	Identity:	196/543 - (36%)
Similarity:	285/543 - (52%)	Gaps:	65/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDIDDQLQAA 74
            |||.||||||||||:|||.|...   :.|:|:.|........:|.||.|||:::|:|:|..|:..
Zfish     8 WFRKGLRLHDNPALIAALKDCRH---IYPLFLLDPWFPKNTRIGINRWRFLIEALKDLDSSLKKL 69

  Fly    75 TDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHT 139
               ..||.|..|.|..:..:|.:|.::.|:..|.|.||....||:.:..|.:|..::...|:|||
Zfish    70 ---NSRLFVVRGSPTEVLPKLFKQWKITRLTFEVDTEPYSQSRDKEVMKLAKEYGVEVTPKISHT 131

  Fly   140 LWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQLPT 204
            |::...:|:.|.|..|:||......|:.:|.|.:|......||...|.                |
Zfish   132 LYNIDRIIDENNGKTPMTYIRLQSVVKAMGHPKKPIPAPTNEDMRGVS----------------T 180

  Fly   205 P---EHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQHA--FERGFYLPNQAL 256
            |   :|...:|    :::|.    |....:.|||.:||..|||.::.....  ||:....||..:
Zfish   181 PLSDDHEEKFGIPTLEDLGLDTSSLGPHLFPGGEQEALRRLDEHMERTNWVCKFEKPKTSPNSLI 245

  Fly   257 PNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAH------ITGQLIWR 315
            |    |...:|.::||||||.|.|:|.:.|:::              |..|      :.|||:||
Zfish   246 P----STTVLSPYVRFGCLSARTFWWRLADVYR--------------GKTHSDPPVSLHGQLLWR 292

  Fly   316 EYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTL 380
            |:|||.:|..||:::||||..|:.:.|.. |...|.:||..:||||.||..|.||..|||:||..
Zfish   293 EFFYTTAVGIPNFNKMEGNSACVQVDWDN-NPEHLAAWREARTGFPFIDTIMTQLRQEGWIHHLA 356

  Fly   381 RNTVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAK 445
            |:.||.|||||.||.|||.|.:.|.:.|||:|||:.||||.|:|:|.|  ......|..|:|..|
Zfish   357 RHAVACFLTRGDLWISWEEGQKVFEELLLDSDWSLNAGNWQWLSASTF--FHQYFRVYSPIAFGK 419

  Fly   446 RLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMK 510
            :.|..|.|||:|:|.|...|.|:::|||:.....||:..|::|..||..|:|..:..|:|:|.||
Zfish   420 KTDKHGDYIKKYLPVLKKFPTEYIYEPWKAPRSVQERAGCIVGKDYPRPIVDHEVVHKKNILRMK 484

  Fly   511 SLRNSLITPPPHCRPSNEEEVRQ 533
            :   :.....|..:..|:.|.|:
Zfish   485 A---AYAKRSPEDKTINKGEKRK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	187/512 (37%)
		DNA_photolyase	8..175	CDD:279247	60/164 (37%)
		FAD_binding_7	310..510	CDD:281440	93/199 (47%)
cry5	NP_571863.1	PhrB	5..486	CDD:223492	192/523 (37%)
		DNA_photolyase	5..170	CDD:279247	61/167 (37%)
		FAD_binding_7	213..485	CDD:281440	120/292 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850