DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and cry2

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_571861.2	Gene:	cry2 / 83774	ZFINID:	ZDB-GENE-010426-6	Length:	598	Species:	Danio rerio

Alignment Length:	539	Identity:	214/539 - (39%)
Similarity:	305/539 - (56%)	Gaps:	49/539 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDIDDQL 71
            :|.|||.||||||||||..||...|   .:..|:|.|...||:.|||.||.||||:||:|:|..|
Zfish     5 SVHWFRKGLRLHDNPALQEALNGAD---TVRCVYILDPWFAGSANVGVNRWRFLLESLEDLDTSL 66

  Fly    72 QAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKV 136
            :..   ..||.|..|:|..:|.||.::..:.|:..|.|.||...|||.:|..:.:|..::.|.:.
Zfish    67 RKL---NSRLFVVRGQPTDVFPRLFKEWNVTRLTFEYDSEPYGKERDAAIIKMAQEYGVETVVRN 128

  Fly   137 SHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQ 201
            :|||::|..:||.|...||||::.|...|..:.||.:|.       .|..:.....||:     |
Zfish   129 THTLYNPDRIIEMNNHSPPLTFKRFQAIVNRLELPRKPL-------PTITQEQMARCRT-----Q 181

  Fly   202 LPT--PEHFNVYG-DNMGFLAKIN----WRGGETQALLLLDERLKVEQHAFERGFYLPNQALPNI 259
            :..  .||:.|.. :.:||..:.:    |:||||:||..|::.|  ::.|:...|..|..:..::
Zfish   182 ISDNHDEHYGVPSLEELGFRTQGDSLHVWKGGETEALERLNKHL--DRKAWVANFERPRISGQSL 244

  Fly   260 HDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFYTMSVN 324
            ..||..:|.:|||||||.|.||:::.|||..::.|:       :....:.|||:|||:|||...|
Zfish   245 FPSPTGLSPYLRFGCLSCRVFYYNLRDLFMKLRRRS-------SPPLSLFGQLLWREFFYTAGTN 302

  Fly   325 NPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLT 389
            |||:|.||||.||:.||| ..|...|..|..|:||||.||..|.||..|||:||..|:.||.|||
Zfish   303 NPNFDHMEGNPICVQIPW-DHNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLT 366

  Fly   390 RGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAKRLDPDGTYI 454
            ||.||.|||.|::.|.:.||||||||.||:|||:|.|||.:......  |||...:|.||.|.||
Zfish   367 RGDLWISWESGMKVFEELLLDADWSVNAGSWMWLSCSAFFQQFFHCY--CPVGFGRRTDPSGDYI 429

  Fly   455 KQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKSLRNSLITP 519
            ::|:|:|.:.|..:::|||......|:...|::||.||:.:|:.:.:.:.|:..||.:...|
Zfish   430 RRYIPKLKDYPNRYIYEPWNAPESVQKAANCIVGVDYPKPMINHAESSRLNIERMKQVYQQL--- 491

  Fly   520 PPHCR--------PSNEEE 530
             .|.|        |:.:||
Zfish   492 -SHYRGLSLLASVPTIQEE 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	205/503 (41%)
		DNA_photolyase	8..175	CDD:279247	70/166 (42%)
		FAD_binding_7	310..510	CDD:281440	97/199 (49%)
cry2	NP_571861.2	PhrB	5..491	CDD:223492	208/515 (40%)
		DNA_photolyase	5..169	CDD:279247	71/176 (40%)
		FAD_binding_7	213..486	CDD:281440	125/284 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950