DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and CRY1

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_567341.1	Gene:	CRY1 / 826470	AraportID:	AT4G08920	Length:	681	Species:	Arabidopsis thaliana

Alignment Length:	560	Identity:	147/560 - (26%)
Similarity:	228/560 - (40%)	Gaps:	148/560 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDIDD 69
            |.:::|||..||:.|||||.||:    :...:|.:|::..|..|..:.|.....:|.:||..:|.
plant    12 GCSIVWFRRDLRVEDNPALAAAV----RAGPVIALFVWAPEEEGHYHPGRVSRWWLKNSLAQLDS 72

  Fly    70 QLQA---------ATDGRGRLL---VFEGEPAYIFRRLHEQ---VRLHR---ICIEQDC------ 110
            .|::         :||....||   ...|.....|..|::.   ||.||   :...|..
plant    73 SLRSLGTCLITKRSTDSVASLLDVVKSTGASQIFFNHLYDPLSLVRDHRAKDVLTAQGIAVRSFN 137

  Fly   111 -----EPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGL 170
                 || |...||..|..  .:...|.|:.....:||:         .||             |
plant   138 ADLLYEP-WEVTDELGRPF--SMFAAFWERCLSMPYDPE---------SPL-------------L 177

  Fly   171 PPRPTADARLEDATFVELDPEFCRSLKLFEQLPTPEHFNVYGDNMGFLAKI---NWRGGETQALL 232
            ||:.....   |.:....||      .:||.      .:..|.| ..||:.   .|..|: :||.
plant   178 PPKKIISG---DVSKCVADP------LVFED------DSEKGSN-ALLARAWSPGWSNGD-KALT 225

  Fly   233 LLDERLKVEQHAFERGFYLPNQALPNIHDSPKS--MSAHLRFGCLSVRRFY---------W---- 282
                       .|..|..|.........||..:  :|.||.||.:|||:.:         |
plant   226 -----------TFINGPLLEYSKNRRKADSATTSFLSPHLHFGEVSVRKVFHLVRIKQVAWANEG 279

  Fly   283 ------SVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFYTMSVNNP-NYDR-MEGNDICLS 339
                  ||:...|::.|                     |||...:|.|:| :::| :.|:  ...
plant   280 NEAGEESVNLFLKSIGL---------------------REYSRYISFNHPYSHERPLLGH--LKF 321

  Fly   340 IPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRGGLWQSWEHGLQHF 404
            .||| .:||..::||.|:||:||:|..||:|.|.||||..:|..|::|..: .|...|..|:::|
plant   322 FPWA-VDENYFKAWRQGRTGYPLVDAGMRELWATGWLHDRIRVVVSSFFVK-VLQLPWRWGMKYF 384

  Fly   405 LKYLLDADWSVCAGNWMWVS-----SSAFERLLDSSLVTCPVALAKRLDPDGTYIKQYVPELMNV 464
            ...|||||....|..|.:::     |..|:| :|:     |.....:.||:|.|:::::|||..:
plant   385 WDTLLDADLESDALGWQYITGTLPDSREFDR-IDN-----PQFEGYKFDPNGEYVRRWLPELSRL 443

  Fly   465 PKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKR 504
            |.:::|.||.......:.....:|.:||..|:.|..|..|
plant   444 PTDWIHHPWNAPESVLQAAGIELGSNYPLPIVGLDEAKAR 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	146/558 (26%)
		DNA_photolyase	8..175	CDD:279247	49/195 (25%)
		FAD_binding_7	310..510	CDD:281440	66/202 (33%)
CRY1	NP_567341.1	crypt_chrom_pln	15..489	CDD:131813	146/557 (26%)
		DNA_photolyase	15..172	CDD:279247	42/163 (26%)
		FAD_binding_7	216..493	CDD:281440	88/311 (28%)
		Cryptochrome_C	520..622	CDD:289323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61092
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830