DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and UVR3

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_566520.1	Gene:	UVR3 / 820804	AraportID:	AT3G15620	Length:	556	Species:	Arabidopsis thaliana

Alignment Length:	525	Identity:	189/525 - (36%)
Similarity:	289/525 - (55%)	Gaps:	51/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATRGANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGE---------SAGTKNVGYNR 56
            |||...::||||.|||:||||||..|....:   .:.|||:.|..         |.|:...|.||
plant    20 MATGSGSLIWFRKGLRVHDNPALEYASKGSE---FMYPVFVIDPHYMESDPSAFSPGSSRAGVNR 81

  Fly    57 MRFLLDSLQDIDDQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESI 121
            :||||:||:|:|..|:..   ..|||||:|||..:..|..::.::.|:|.|.|.:|.:...|..:
plant    82 IRFLLESLKDLDSSLKKL---GSRLLVFKGEPGEVLVRCLQEWKVKRLCFEYDTDPYYQALDVKV 143

  Fly   122 RSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFV 186
            :.......::....|||||::|..:||.|||.|||:||.||   ::.|.|....::..:   ::.
plant   144 KDYASSTGVEVFSPVSHTLFNPAHIIEKNGGKPPLSYQSFL---KVAGEPSCAKSELVM---SYS 202

  Fly   187 ELDPEFCRSLKLFEQLPTPEHFNVYGDNMGFLAKINW---RGGETQALLLLDERLKVEQHAFERG 248
            .|.|..........::|:.|......|.     :.:|   ||||::||..|.:  .:...|:...
plant   203 SLPPIGDIGNLGISEVPSLEELGYKDDE-----QADWTPFRGGESEALKRLTK--SISDKAWVAN 260

  Fly   249 FYLPNQALPNIHDSPKS--MSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQ 311
            |..| :..|:....|.:  ||.:|:|||||.|.||..:.:::|:|:...       :....:.||
plant   261 FEKP-KGDPSAFLKPATTVMSPYLKFGCLSSRYFYQCLQNIYKDVKKHT-------SPPVSLLGQ 317

  Fly   312 LIWREYFYTMSVNNPNYDRMEGNDICLSIPWAKPNEN--LLQSWRLGQTGFPLIDGAMRQLLAEG 374
            |:|||:|||.:...||:|:|:||.||..|||   ||:  :|.:||.|:||:|.||..|.|||..|
plant   318 LLWREFFYTTAFGTPNFDKMKGNRICKQIPW---NEDHAMLAAWRDGKTGYPWIDAIMVQLLKWG 379

  Fly   375 WLHHTLRNTVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTC 439
            |:||..|:.||.|||||.|:..||.|...|.:.|:|:||::..|||||:|.|:|  ....:.:..
plant   380 WMHHLARHCVACFLTRGDLFIHWEQGRDVFERLLIDSDWAINNGNWMWLSCSSF--FYQFNRIYS 442

  Fly   440 PVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERII---DLSMA 501
            |::..|:.||||.||:.::|.|.::||::::|||......|.:..|::|..||:.::   ..|..
plant   443 PISFGKKYDPDGKYIRHFLPVLKDMPKQYIYEPWTAPLSVQTKANCIVGKDYPKPMVLHDSASKE 507

  Fly   502 VKRNM 506
            .||.|
plant   508 CKRKM 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	183/518 (35%)
		DNA_photolyase	8..175	CDD:279247	67/175 (38%)
		FAD_binding_7	310..510	CDD:281440	88/202 (44%)
UVR3	NP_566520.1	PhrB	26..510	CDD:223492	183/515 (36%)
		DNA_photolyase	26..185	CDD:279247	65/167 (39%)
		FAD_binding_7	240..514	CDD:281440	111/288 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11455
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880