DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and cry3a

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_571866.2	Gene:	cry3a / 573209	ZFINID:	ZDB-GENE-010426-4	Length:	659	Species:	Danio rerio

Alignment Length:	522	Identity:	205/522 - (39%)
Similarity:	290/522 - (55%)	Gaps:	47/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDIDDQL 71
            ::.|||.||||||||||..|:...|   .:..|:..|...||:.|:|.||.||||..|.|:|..|
Zfish     5 SIHWFRKGLRLHDNPALQEAVRGAD---TVRCVYFLDPWFAGSSNLGVNRWRFLLQCLDDLDSNL 66

  Fly    72 QAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKV 136
            :..   ..||.|..|:||.:|.||.::.::.|:..|.|.||...|||.:|:.|..|..::.:.|.
Zfish    67 RKL---NSRLFVVRGQPANVFPRLFKEWKISRLTFEYDSEPFGKERDAAIKKLAMEAGVEVIVKT 128

  Fly   137 SHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQ 201
            ||||::...:||.|||.|||||:.|...:..:..|..|....                |..:...
Zfish   129 SHTLYNLDKIIELNGGQPPLTYKRFQTLISRMDPPEMPVETL----------------SNSIMGC 177

  Fly   202 LPTP---EHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQHAFERGFYLPNQA 255
            ..||   :|.:.||    :.:||    |....|.||||:||..::..|  |:.|:...|..|...
Zfish   178 CVTPVSEDHGDKYGVPSLEELGFDIEGLPSAVWPGGETEALTRIERHL--ERKAWVANFERPRMN 240

  Fly   256 LPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFYT 320
            ..::..||..:|.:|||||||.|.||:.:.||::.|:..:       |....:.|||:|||:|||
Zfish   241 ANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRKVKKTS-------TPPLSLYGQLLWREFFYT 298

  Fly   321 MSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVA 385
            .:..||.:|:||||.||:.|||.| |...|..|...:||||.||..|.||..|||:||..|:.||
Zfish   299 AATTNPRFDKMEGNPICVRIPWDK-NPEALAKWAEAKTGFPWIDAIMTQLRQEGWIHHLARHAVA 362

  Fly   386 TFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVS-SSAFERLLDSSLVTCPVALAKRLDP 449
            .|||||.||.|||.|::.|.:.||||||||.||:|||:| ||.|::...   ..|||...:|.||
Zfish   363 CFLTRGDLWISWEEGMKVFEELLLDADWSVNAGSWMWLSCSSFFQQFFH---CYCPVGFGRRTDP 424

  Fly   450 DGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKSLRN 514
            :|.:|::|:|.|...|.:::::||......|...:|:||||||:.:::.:.|.:.|:..||.:..
Zfish   425 NGDFIRRYLPILRGFPAKYIYDPWNAPDSVQAAAKCIIGVHYPKPMVNHAEASRLNIERMKQIYQ 489

  Fly   515 SL 516
            .|
Zfish   490 QL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	201/508 (40%)
		DNA_photolyase	8..175	CDD:279247	68/166 (41%)
		FAD_binding_7	310..510	CDD:281440	95/200 (48%)
cry3a	NP_571866.2	PhrB	5..491	CDD:223492	204/520 (39%)
		DNA_photolyase	5..166	CDD:279247	68/166 (41%)
		FAD_binding_7	213..486	CDD:281440	123/285 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820