DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cry and phr6-4

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001260632.1	Gene:	phr6-4 / 35322	FlyBaseID:	FBgn0016054	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	200/521 - (38%)
Similarity:	282/521 - (54%)	Gaps:	46/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RGANVIWFRHGLRLHDNPAL--LAALADKDQGIALI-PVFIFDGESAGTKNVGYNRMRFLLDSLQ 65
            |...|.|||.||||||||||  :...|:...|...: |:||.|........||.||.|||..:|:
  Fly     5 RSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQQTLE 69

  Fly    66 DIDDQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNI 130
            |:|:||:..   ..||.|..|:||.:|.|:.:..|:..:..|.|.||....||.:::.|.:...:
  Fly    70 DLDNQLRKL---NSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGV 131

  Fly   131 DFVEKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQ------IIGLP------PRPTADARLEDA 183
            ......|||:::|:|||..|.|..|:|||.||..|:      ::|:|      |.|..| .:|..
  Fly   132 RVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKD-EVEQK 195

  Fly   184 TFVELDPEFCRSLKLFEQLPTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLKVEQHAFERG 248
            .....|   |.::|  :.:..||..   |.|       .:.||||:||..::|.||.|  .:...
  Fly   196 DSAAYD---CPTMK--QLVKRPEEL---GPN-------KFPGGETEALRRMEESLKDE--IWVAR 243

  Fly   249 FYLPNQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLI 313
            |..||.|..::..|...:|.:|:|||||.|.|...:.::.|.       :.........:.|||:
  Fly   244 FEKPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKR-------QPKHSQPPVSLIGQLM 301

  Fly   314 WREYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHH 378
            |||::||::...||:|||.||..|:.|||.:..:: |::|..|:||:|.||..||||..|||:||
  Fly   302 WREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDH-LEAWTHGRTGYPFIDAIMRQLRQEGWIHH 365

  Fly   379 TLRNTVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVAL 443
            ..|:.||.|||||.||.|||.|.:.|.:.|||.||::.||||||:|:|||  ......|..|||.
  Fly   366 LARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWALNAGNWMWLSASAF--FHQYFRVYSPVAF 428

  Fly   444 AKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLA 508
            .|:.||.|.||::|||||...|...::|||:.|...|..|.|::|..||.||:...:..|.|:..
  Fly   429 GKKTDPQGHYIRKYVPELSKYPAGCIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKR 493

  Fly   509 M 509
            |
  Fly   494 M 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	197/514 (38%)
		DNA_photolyase	8..175	CDD:279247	67/181 (37%)
		FAD_binding_7	310..510	CDD:281440	97/200 (49%)
phr6-4	NP_001260632.1	PhrB	5..499	CDD:223492	200/521 (38%)
phr6-4	NP_001260632.1	FAD_binding_7	297..496	CDD:377037	97/201 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I195
eggNOG	1	0.900	-	-		E1_COG0415
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I205
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S3590
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D28416at33392
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	1	1.000	-	-		otm51351
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11455
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
	11	10.950