Protein Alignment cry and CRY2

DIOPT Version :9

• Sequence 1: NP_732407.1
• Gene: cry / 42305
• FlyBaseID: FBgn0025680
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_066940.3
• Gene: CRY2 / 1408
• HGNCID: 2385
• Length: 593
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 216/535 - (40%)
• Similarity: 300/535 - (56%)
• Gaps: 49/535 - (9%)

  Fly     6 ANVIWFRHGLRLHDNPALLAALADKDQGIALIP-VFIFDGESAGTKNVGYNRMRFLLDSLQDIDD 69
            ::|.|||.|||||||||||||:    :|...:. |:|.|...|.:.:||.||.||||.||:|:|.
Human    23 SSVHWFRKGLRLHDNPALLAAV----RGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDT 83

  Fly    70 QLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVE 134
            .|:..   ..||.|..|:||.:|.||.::..:.|:..|.|.||...|||.:|..:.:|..::.|.
Human    84 SLRKL---NSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVT 145

  Fly   135 KVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLF 199
            :.||||:|...:||.||..|||||:.|...:..:.||.:|.       ........|.||: ::.
Human   146 ENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPV-------GLVTSQQMESCRA-EIQ 202

  Fly   200 EQLPTPEHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQHAFERGFYLPNQAL 256
            |     .|...||    :.:||    |....|:||||:||..||:.|  |:.|:...:..|....
Human   203 E-----NHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHL--ERKAWVANYERPRMNA 260

  Fly   257 PNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFYTM 321
            .::..||..:|.:|||||||.|.||:.:.||:|.|:..:       |....:.|||:|||:|||.
Human   261 NSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNS-------TPPLSLFGQLLWREFFYTA 318

  Fly   322 SVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVAT 386
            :.|||.:||||||.||:.|||.: |...|..|..|:||||.||..|.||..|||:||..|:.||.
Human   319 ATNNPRFDRMEGNPICIQIPWDR-NPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVAC 382

  Fly   387 FLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAKRLDPDG 451
            |||||.||.|||.|::.|.:.|||||:||.||:|||:|.|||.:......  |||...:|.||.|
Human   383 FLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCY--CPVGFGRRTDPSG 445

  Fly   452 TYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKSLRNS- 515
            .||::|:|:|...|..:::|||......|:..:|:|||.||..|::.:...:.|:..||.:...
Human   446 DYIRRYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQL 510

  Fly   516 -------LITPPPHC 523
                   |:...|.|
Human   511 SRYRGLCLLASVPSC 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	210/506 (42%)
		DNA_photolyase	8..175	CDD:279247	72/167 (43%)
		FAD_binding_7	310..510	CDD:281440	97/199 (49%)
CRY2	NP_066940.3	PhrB	22..510	CDD:223492	213/518 (41%)
		FAD_binding_7	307..505	CDD:308829	98/200 (49%)
		Required for inhibition of CLOCK-ARNTL-mediated transcription. /evidence=ECO:0000250|UniProtKB:Q9R194	390..489		45/100 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..593

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S3590
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.900