DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cry and CRY2

DIOPT Version :10

Sequence 1:NP_732407.1 Gene:cry / 42305 FlyBaseID:FBgn0025680 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_066940.3 Gene:CRY2 / 1408 HGNCID:2385 Length:593 Species:Homo sapiens


Alignment Length:535 Identity:216/535 - (40%)
Similarity:300/535 - (56%) Gaps:49/535 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ANVIWFRHGLRLHDNPALLAALADKDQGIALIP-VFIFDGESAGTKNVGYNRMRFLLDSLQDIDD 69
            ::|.|||.|||||||||||||:    :|...:. |:|.|...|.:.:||.||.||||.||:|:|.
Human    23 SSVHWFRKGLRLHDNPALLAAV----RGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDT 83

  Fly    70 QLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVE 134
            .|:..   ..||.|..|:||.:|.||.::..:.|:..|.|.||...|||.:|..:.:|..::.|.
Human    84 SLRKL---NSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVT 145

  Fly   135 KVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLF 199
            :.||||:|...:||.||..|||||:.|...:..:.||.:|.       ........|.||: ::.
Human   146 ENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPV-------GLVTSQQMESCRA-EIQ 202

  Fly   200 EQLPTPEHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQHAFERGFYLPNQAL 256
            |     .|...||    :.:||    |....|:||||:||..||:.|  |:.|:...:..|....
Human   203 E-----NHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHL--ERKAWVANYERPRMNA 260

  Fly   257 PNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFYTM 321
            .::..||..:|.:|||||||.|.||:.:.||:|.|:..:       |....:.|||:|||:|||.
Human   261 NSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNS-------TPPLSLFGQLLWREFFYTA 318

  Fly   322 SVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVAT 386
            :.|||.:||||||.||:.|||.: |...|..|..|:||||.||..|.||..|||:||..|:.||.
Human   319 ATNNPRFDRMEGNPICIQIPWDR-NPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVAC 382

  Fly   387 FLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAKRLDPDG 451
            |||||.||.|||.|::.|.:.|||||:||.||:|||:|.|||.:......  |||...:|.||.|
Human   383 FLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCY--CPVGFGRRTDPSG 445

  Fly   452 TYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKSLRNS- 515
            .||::|:|:|...|..:::|||......|:..:|:|||.||..|::.:...:.|:..||.:... 
Human   446 DYIRRYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQL 510

  Fly   516 -------LITPPPHC 523
                   |:...|.|
Human   511 SRYRGLCLLASVPSC 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cryNP_732407.1 PhrB 8..513 CDD:440184 213/513 (42%)
CRY2NP_066940.3 PhrB 21..506 CDD:440184 213/514 (41%)
Required for inhibition of CLOCK-BMAL1-mediated transcription. /evidence=ECO:0000250|UniProtKB:Q9R194 390..489 45/100 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..593
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.