DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and CRY1

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_024304612.1	Gene:	CRY1 / 1407	HGNCID:	2384	Length:	632	Species:	Homo sapiens

Alignment Length:	525	Identity:	214/525 - (40%)
Similarity:	304/525 - (57%)	Gaps:	48/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GANVI-WFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDID 68
            |.|.: |||.||||||||||...:...|   .:..|:|.|...||:.|||.||.||||..|:|:|
Human     2 GVNAVHWFRKGLRLHDNPALKECIQGAD---TIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLD 63

  Fly    69 DQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFV 133
            ..|:..   ..||.|..|:||.:|.||.::..:.::.||.|.||...|||.:|:.|..|..::.:
Human    64 ANLRKL---NSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVI 125

  Fly   134 EKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKL 198
            .::||||:|...:||.|||.|||||:.|            .|..:::|.   :|:..|...| ::
Human   126 VRISHTLYDLDKIIELNGGQPPLTYKRF------------QTLISKMEP---LEIPVETITS-EV 174

  Fly   199 FEQLPTP---EHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQHAFERGFYLP 252
            .|:..||   :|...||    :.:||    |:...|.||||:||..|:..|  |:.|:...|..|
Human   175 IEKCTTPLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEALTRLERHL--ERKAWVANFERP 237

  Fly   253 NQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREY 317
            .....::..||..:|.:|||||||.|.||:.:.||:|.|:..:       :....:.|||:|||:
Human   238 RMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNS-------SPPLSLYGQLLWREF 295

  Fly   318 FYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRN 382
            |||.:.|||.:|:||||.||:.|||.| |...|..|..|:||||.||..|.||..|||:||..|:
Human   296 FYTAATNNPRFDKMEGNPICVQIPWDK-NPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARH 359

  Fly   383 TVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVS-SSAFERLLDSSLVTCPVALAKR 446
            .||.|||||.||.|||.|::.|.:.|||||||:.||:|||:| ||.|::...   ..|||...:|
Human   360 AVACFLTRGDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQFFH---CYCPVGFGRR 421

  Fly   447 LDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKS 511
            .||:|.||::|:|.|...|.:::::||......|:..:|||||:||:.:::.:.|.:.|:..||.
Human   422 TDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQ 486

  Fly   512 LRNSL 516
            :...|
Human   487 IYQQL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	210/511 (41%)
		DNA_photolyase	8..175	CDD:279247	68/167 (41%)
		FAD_binding_7	310..510	CDD:281440	97/200 (49%)
CRY1	XP_024304612.1	PhrB	6..491	CDD:223492	211/519 (41%)
CRY1	XP_024304612.1	FAD_binding_7	288..486	CDD:308829	98/201 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850