DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and Cry1

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_031797.1	Gene:	Cry1 / 12952	MGIID:	1270841	Length:	606	Species:	Mus musculus

Alignment Length:	525	Identity:	213/525 - (40%)
Similarity:	298/525 - (56%)	Gaps:	48/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GANVI-WFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDID 68
            |.|.: |||.||||||||||...:...|   .:..|:|.|...||:.|||.||.||||..|:|:|
Mouse     2 GVNAVHWFRKGLRLHDNPALKECIQGAD---TIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLD 63

  Fly    69 DQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFV 133
            ..|:..   ..||.|..|:||.:|.||.::..:.::.||.|.||...|||.:|:.|..|..::.:
Mouse    64 ANLRKL---NSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVI 125

  Fly   134 EKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKL 198
            .::||||:|...:||.|||.|||||:.|...|..:. |....||....|               :
Mouse   126 VRISHTLYDLDKIIELNGGQPPLTYKRFQTLVSKME-PLEMPADTITSD---------------V 174

  Fly   199 FEQLPTP---EHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQHAFERGFYLP 252
            ..:..||   :|...||    :.:||    |:...|.||||:||..|:..|  |:.|:...|..|
Mouse   175 IGKCMTPLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEALTRLERHL--ERKAWVANFERP 237

  Fly   253 NQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREY 317
            .....::..||..:|.:|||||||.|.||:.:.||:|.|:..:       :....:.|||:|||:
Mouse   238 RMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNS-------SPPLSLYGQLLWREF 295

  Fly   318 FYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRN 382
            |||.:.|||.:|:||||.||:.|||.| |...|..|..|:||||.||..|.||..|||:||..|:
Mouse   296 FYTAATNNPRFDKMEGNPICVQIPWDK-NPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARH 359

  Fly   383 TVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVS-SSAFERLLDSSLVTCPVALAKR 446
            .||.|||||.||.|||.|::.|.:.|||||||:.||:|||:| ||.|::...   ..|||...:|
Mouse   360 AVACFLTRGDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQFFH---CYCPVGFGRR 421

  Fly   447 LDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKS 511
            .||:|.||::|:|.|...|.:::::||......|:..:|||||:||:.:::.:.|.:.|:..||.
Mouse   422 TDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQ 486

  Fly   512 LRNSL 516
            :...|
Mouse   487 IYQQL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	209/511 (41%)
		DNA_photolyase	8..175	CDD:279247	70/167 (42%)
		FAD_binding_7	310..510	CDD:281440	97/200 (49%)
Cry1	NP_031797.1	DNA_photolyase	5..167	CDD:279247	70/168 (42%)
		PhrB	6..491	CDD:223492	210/519 (40%)
		LIR 1. /evidence=ECO:0000305\|PubMed:29937374	50..54		2/3 (67%)
		LIR 2. /evidence=ECO:0000305\|PubMed:29937374	82..87		1/4 (25%)
		LIR 3. /evidence=ECO:0000305\|PubMed:29937374	151..156		1/4 (25%)
		FAD_binding_7	213..486	CDD:281440	126/285 (44%)
		LIR 4. /evidence=ECO:0000305\|PubMed:29937374	255..260		4/4 (100%)
		LIR 5. /evidence=ECO:0000305\|PubMed:29937374	271..276		3/4 (75%)
		LIR 6. /evidence=ECO:0000305\|PubMed:29937374	285..290		1/4 (25%)
		LIR 7. /evidence=ECO:0000305\|PubMed:29937374	335..339		3/3 (100%)
		Required for inhibition of CLOCK-ARNTL/BMAL1-mediated transcription. /evidence=ECO:0000269\|PubMed:16478995	371..470		45/101 (45%)
		LIR 8. /evidence=ECO:0000305\|PubMed:29937374	379..384		1/4 (25%)
		LIR 9. /evidence=ECO:0000305\|PubMed:29937374	395..400		3/4 (75%)
		LIR 10. /evidence=ECO:0000305\|PubMed:29937374	411..416		1/7 (14%)
		LIR 11. /evidence=ECO:0000305\|PubMed:29937374	430..435		1/4 (25%)
		Interaction with TIMELESS. /evidence=ECO:0000269\|PubMed:23418588	471..493		5/21 (24%)
		LIR 12. /evidence=ECO:0000305\|PubMed:29937374	486..491		0/4 (0%)
		LIR 13. /evidence=ECO:0000305\|PubMed:29937374	492..497		213/525 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850