DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and cry4

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_012812443.1	Gene:	cry4 / 100170456	XenbaseID:	XB-GENE-5945160	Length:	558	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	196/523 - (37%)
Similarity:	283/523 - (54%)	Gaps:	63/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNV-GYNRMRFLLDSLQDIDDQLQAA 74
            ||.||||||||.|:.||...|   .:.||:|.|.....:.:| |..|..|.|.|::|:...||..
Frog     9 FRKGLRLHDNPTLVTALETSD---VVYPVYILDRNFMTSSSVIGSKRWNFFLQSIEDLHCNLQKL 70

  Fly    75 TDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHT 139
               ...|.|.:|:...:.|...|:..:.::..:.:.||.:...||.||::.:||..:.|..|:||
Frog    71 ---NSCLFVIQGDYERVLREHVEKWNITQVTFDLEIEPYYKGLDERIRAMGQELGFEVVSMVAHT 132

  Fly   140 LWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRS----LKL-- 198
            |:|.:.::..|.|.|||||:.||..:.:||.|.:|......||         |.|.    .||
Frog   133 LYDIKTILALNCGKPPLTYKNFLRVLSMIGNPDKPARQITSED---------FIRKCITPTKLAA 188

  Fly   199 --FEQLPTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLKVEQHAFERGFY--------LPN 253
              :.::|.||...:..|     ...||.|||::||      .::|||..::|:.        :||
Frog   189 EEYYRIPKPEDLGISKD-----CPTNWVGGESEAL------SRLEQHLEKQGWVANFKKPQTIPN 242

  Fly   254 QALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLF---KNVQLRACVRGVQMTGGAHITGQLIWR 315
            ..||    |...:|.:...||||||.|:..:.:::   ||..|..          ..:.|||:||
Frog   243 SLLP----STTGLSPYFSLGCLSVRVFFHRLSNIYAQSKNHSLPP----------VSLQGQLLWR 293

  Fly   316 EYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTL 380
            |:|||::.:.||:..|.||.|||.|.|.| ||..||.|:..:||||.||..|.||..|||:||..
Frog   294 EFFYTVASSTPNFTHMVGNPICLQIDWYK-NEEQLQKWKEAKTGFPWIDAIMTQLHNEGWIHHLA 357

  Fly   381 RNTVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAK 445
            |:.||.|||||.||.|||.|::.|.::|||||:.:.||||||:|:|||  ....:.:.|||...:
Frog   358 RHAVACFLTRGDLWISWEEGMKVFEEFLLDADYCINAGNWMWLSASAF--FHHYTRIFCPVRFGR 420

  Fly   446 RLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMK 510
            |.||:|.||::|:|.|.|.|.::::|||....|.|:|..||||..||..::|...|.:.|:..|:
Frog   421 RSDPEGNYIRKYLPVLKNFPAKYIYEPWTAPEEIQKQAGCLIGKDYPLPMVDHKTASEHNLQLMR 485

  Fly   511 SLR 513
            .:|
Frog   486 QVR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	193/512 (38%)
		DNA_photolyase	8..175	CDD:279247	58/164 (35%)
		FAD_binding_7	310..510	CDD:281440	98/199 (49%)
cry4	XP_012812443.1	PhrB	5..488	CDD:223492	195/521 (37%)
		DNA_photolyase	5..170	CDD:279247	59/166 (36%)
		FAD_binding_7	213..486	CDD:281440	123/295 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010